| Sep 8, 2016 | Incarnate Word 21, Northwestern State 18upset | Box score |
| Sep 8, 2016 | Eastern Kentucky 55, Pikeville 14 | Box score |
| Sep 10, 2016 | 9Georgia 26, Nicholls 24 | Box score |
| Sep 10, 2016 | 20Texas A&M 67, Prairie View A&M 0 | Box score |
| Sep 10, 2016 | 6Houston 42, Lamar 0 | Box score |
| Sep 10, 2016 | Rutgers 52, Howard 14 | Box score |
| Sep 10, 2016 | Minnesota 58, Indiana State 28 | Box score |
| Sep 10, 2016 | Wagner 38, Concordia-Michigan 0 | Box score |
| Sep 10, 2016 | 3Florida State 52, Charleston Southern 8 | Box score |
| Sep 10, 2016 | Temple 38, Stony Brook 0 | Box score |
| Sep 10, 2016 | UAlbany 35, Rhode Island 7 | Box score |
| Sep 10, 2016 | Dayton 13, Robert Morris 0 | Box score |
| Sep 10, 2016 | Sacred Heart 42, Valparaiso 14 | Box score |
| Sep 10, 2016 | Fordham 83, Elizabeth City State 21 | Box score |
| Sep 10, 2016 | West Virginia 38, Youngstown State 21 | Box score |
| Sep 10, 2016 | Chattanooga 34, Presbyterian 0 | Box score |
| Sep 10, 2016 | Davidson 35, Kentucky Wesleyan 21 | Box score |
| Sep 10, 2016 | Georgia Tech 35, Mercer 10 | Box score |
| Sep 10, 2016 | South Dakota 52, Weber State 49 | Box score |
| Sep 10, 2016 | Bowling Green 27, North Dakota 26 | Box score |
| Sep 10, 2016 | Illinois State 9, Northwestern 7 | Box score |
| Sep 10, 2016 | North Dakota State 50, Eastern Washington 44 | Box score |
| Sep 10, 2016 | 19Ole Miss 38, Wofford 13 | Box score |
| Sep 10, 2016 | Montana State 27, Bryant 24 | Box score |
| Sep 10, 2016 | Western Illinois 34, Northern Arizona 20 | Box score |
| Sep 10, 2016 | James Madison 56, Central Connecticut 21 | Box score |
| Sep 10, 2016 | San José State 66, Portland State 35 | Box score |
| Sep 10, 2016 | Eastern Illinois 21, Miami (OH) 17 | Box score |
| Sep 10, 2016 | Montana 20, Northern Iowa 14 | Box score |
| Sep 10, 2016 | Monmouth 34, Delaware State 20 | Box score |
| Sep 10, 2016 | Alabama A&M 35, Mississippi Valley State 16 | Box score |
| Sep 10, 2016 | Colorado 56, Idaho State 7 | Box score |
| Sep 10, 2016 | North Carolina A&T 39, Kent State 36 | Box score |
| Sep 10, 2016 | Charlotte 47, Elon 14 | Box score |
| Sep 10, 2016 | Marshall 62, Morgan State 0 | Box score |
| Sep 10, 2016 | The Citadel 19, Furman 14 | Box score |
| Sep 10, 2016 | VMI 17, Morehead State 13upset | Box score |
| Sep 10, 2016 | Western Carolina 44, Gardner-Webb 14 | Box score |
| Sep 10, 2016 | Delaware 24, Lafayette 6 | Box score |
| Sep 10, 2016 | Towson 35, Saint Francis 28 | Box score |
| Sep 10, 2016 | Villanova 26, Lehigh 21 | Box score |
| Sep 10, 2016 | William & Mary 24, Hampton 14 | Box score |
| Sep 10, 2016 | Richmond 34, Norfolk State 0 | Box score |
| Sep 10, 2016 | Campbell 47, Chowan 14 | Box score |
| Sep 10, 2016 | Georgetown 20, Marist 17 | Box score |
| Sep 10, 2016 | Duquesne 30, Bucknell 19 | Box score |
| Sep 10, 2016 | Butler 59, Franklin 14 | Box score |
| Sep 10, 2016 | Coastal Carolina 49, Florida A&M 10 | Box score |
| Sep 10, 2016 | Toledo 45, Maine 3 | Box score |
| Sep 10, 2016 | Western Michigan 70, North Carolina Central 21 | Box score |
| Sep 10, 2016 | Louisiana Tech 53, South Carolina State 24 | Box score |
| Sep 10, 2016 | North Texas 41, Bethune-Cookman 20 | Box score |
| Sep 10, 2016 | Southern Miss 56, Savannah State 0 | Box score |
| Sep 10, 2016 | Northern Colorado 55, Abilene Christian 52 | Box score |
| Sep 10, 2016 | Louisiana 30, McNeese 22 | Box score |
| Sep 10, 2016 | Missouri State 28, Murray State 22 | Box score |
| Sep 10, 2016 | South Dakota State 56, Drake 28 | Box score |
| Sep 10, 2016 | Southern Illinois 30, Southeast Missouri State 22 | Box score |
| Sep 10, 2016 | Samford 35, Central Arkansas 29 | Box score |
| Sep 10, 2016 | Stephen F. Austin 30, West Alabama 24 | Box score |
| Sep 10, 2016 | Kennesaw State 49, Point University 3 | Box score |
| Sep 10, 2016 | Liberty 55, Jacksonville 7 | Box score |
| Sep 10, 2016 | New Hampshire 39, Holy Cross 28 | Box score |
| Sep 10, 2016 | Tennessee Tech 41, Austin Peay 7 | Box score |
| Sep 10, 2016 | Tennessee State 40, Jackson State 26 | Box score |
| Sep 10, 2016 | Stetson 30, Warner 15 | Box score |
| Sep 10, 2016 | Alcorn State 21, Alabama State 18 | Box score |
| Sep 10, 2016 | Oklahoma Panhandle 20, Arkansas–Pine Bluff 16 | Box score |
| Sep 10, 2016 | Cal Poly 38, San Diego 16 | Box score |
| Sep 10, 2016 | 21LSU 34, Jacksonville State 13 | Box score |
| Sep 10, 2016 | Tulane 66, Southern 21 | Box score |
| Sep 10, 2016 | Southern Utah 28, SE Louisiana 23 | Box score |
| Sep 10, 2016 | Houston Christian 24, Texas Southern 20 | Box score |
| Sep 10, 2016 | UC Davis 52, Southern Oregon 35 | Box score |
| Sep 10, 2016 | Fresno State 31, Sacramento State 3 | Box score |
| Sep 10, 2016 | Arizona 31, Grambling 21 | Box score |
| Sep 10, 2016 | Hawai’i 41, UT Martin 36 | Box score |