| Sep 30, 1949 | Boston College 13, Wake Forest 7 | Box score |
| Sep 30, 1949 | Furman 14, South Carolina 7upset | Box score |
| Sep 30, 1949 | Maryland 33, Georgetown 7 | Box score |
| Sep 30, 1949 | New Mexico 14, New Mexico State 13 | Box score |
| Sep 30, 1949 | San Francisco 27, Loyola Marymount 12 | Box score |
| Sep 30, 1949 | UCLA 35, Oregon 27 | Box score |
| Sep 30, 1949 | Villanova 34, Detroit Mercy 7 | Box score |
| Oct 1, 1949 | Arkansas 27, TCU 7 | Box score |
| Oct 1, 1949 | Army 42, Penn State 7 | Box score |
| Oct 1, 1949 | Baylor 14, Mississippi State 6 | Box score |
| Oct 1, 1949 | Brown 28, Holy Cross 6 | Box score |
| Oct 1, 1949 | California 41, Oregon State 0 | Box score |
| Oct 1, 1949 | Clemson 7, NC State 6 | Box score |
| Oct 1, 1949 | Columbia 14, Harvard 7 | Box score |
| Oct 1, 1949 | Cornell 39, Colgate 27 | Box score |
| Oct 1, 1949 | Drake 17, Bradley 7 | Box score |
| Oct 1, 1949 | Duke 21, Tennessee 7 | Box score |
| Oct 1, 1949 | Florida 40, Tulsa 7 | Box score |
| Oct 1, 1949 | Hardin Simmons 34, Arizona State 13 | Box score |
| Oct 1, 1949 | Iowa 21, Purdue 7 | Box score |
| Oct 1, 1949 | Iowa State 19, Kansas 6upset | Box score |
| Oct 1, 1949 | Kansas State 27, Colorado 13 | Box score |
| Oct 1, 1949 | Kentucky 47, Ole Miss 0upset | Box score |
| Oct 1, 1949 | LSU 14, Rice 7 | Box score |
| Oct 1, 1949 | Michigan 27, Stanford 7 | Box score |
| Oct 1, 1949 | Michigan State 48, Marquette 7 | Box score |
| Oct 1, 1949 | Minnesota 28, Nebraska 6 | Box score |
| Oct 1, 1949 | Montana 16, Utah State 13 | Box score |
| Oct 1, 1949 | Navy 28, Princeton 7 | Box score |
| Oct 1, 1949 | North Carolina 21, Georgia 14 | Box score |
| Oct 1, 1949 | Notre Dame 27, Washington 7 | Box score |
| Oct 1, 1949 | Ohio State 46, Indiana 7 | Box score |
| Oct 1, 1949 | Oklahoma 33, Texas A&M 13 | Box score |
| Oct 1, 1949 | Oklahoma State 48, Denver 2 | Box score |
| Oct 1, 1949 | Pennsylvania 21, Dartmouth 0 | Box score |
| Oct 1, 1949 | Pittsburgh 16, Northwestern 7upset | Box score |
| Oct 1, 1949 | USC 35, Washington State 7 | Box score |
| Oct 1, 1949 | SMU 28, Missouri 27 | Box score |
| Oct 1, 1949 | Syracuse 20, Lafayette 13 | Box score |
| Oct 1, 1949 | Temple 14, Rutgers 7 | Box score |
| Oct 1, 1949 | Texas 56, Idaho 7 | Box score |
| Oct 1, 1949 | Texas Tech 35, West Texas 19 | Box score |
| Oct 1, 1949 | Tulane 18, Georgia Tech 0 | Box score |
| Oct 1, 1949 | Arizona 12, Utah 12 | Box score |
| Oct 1, 1949 | Vanderbilt 14, Alabama 7 | Box score |
| Oct 1, 1949 | Virginia 21, Miami (OH) 18 | Box score |
| Oct 1, 1949 | VMI 14, George Washington 7 | Box score |
| Oct 1, 1949 | West Virginia 28, Washington and Lee 20 | Box score |
| Oct 1, 1949 | William & Mary 39, Virginia Tech 13 | Box score |
| Oct 1, 1949 | Illinois 13, Wisconsin 13 | Box score |
| Oct 1, 1949 | Wyoming 8, Colorado State 0 | Box score |
| Oct 2, 1949 | Saint Mary’s (CA) 20, Nevada 14upset | Box score |