| Sep 23, 1949 | Boston University 33, Syracuse 21 | Box score |
| Sep 23, 1949 | Detroit Mercy 20, Tulsa 14 | Box score |
| Sep 23, 1949 | Ole Miss 40, Auburn 7 | Box score |
| Sep 23, 1949 | Oklahoma 46, Boston College 0 | Box score |
| Sep 23, 1949 | Washington and Lee 27, Furman 7 | Box score |
| Sep 24, 1949 | Arizona 40, New Mexico State 7 | Box score |
| Sep 24, 1949 | Army 47, Davidson 7 | Box score |
| Sep 24, 1949 | Baylor 20, South Carolina 6 | Box score |
| Sep 24, 1949 | California 29, Saint Mary’s (CA) 7 | Box score |
| Sep 24, 1949 | Cincinnati 27, Hardin Simmons 21upset | Box score |
| Sep 24, 1949 | Colorado 13, Kansas 12 | Box score |
| Sep 24, 1949 | Colorado State 14, Denver 13 | Box score |
| Sep 24, 1949 | Duke 67, Richmond 0 | Box score |
| Sep 24, 1949 | Florida 13, The Citadel 0 | Box score |
| Sep 24, 1949 | Georgetown 20, Holy Cross 13 | Box score |
| Sep 24, 1949 | Georgia Tech 12, Vanderbilt 7 | Box score |
| Sep 24, 1949 | Illinois 20, Iowa State 20 | Box score |
| Sep 24, 1949 | Kentucky 19, LSU 0 | Box score |
| Sep 24, 1949 | Maryland 34, Virginia Tech 7 | Box score |
| Sep 24, 1949 | Miami (OH) 23, Wichita State 6 | Box score |
| Sep 24, 1949 | Michigan 7, Michigan State 3 | Box score |
| Sep 24, 1949 | Minnesota 48, Washington 20 | Box score |
| Sep 24, 1949 | North Carolina 26, NC State 6 | Box score |
| Sep 24, 1949 | Northwestern 20, Purdue 6 | Box score |
| Sep 24, 1949 | Notre Dame 49, Indiana 6 | Box score |
| Sep 24, 1949 | Ohio 17, West Virginia 7upset | Box score |
| Sep 24, 1949 | Ohio State 35, Missouri 34 | Box score |
| Sep 24, 1949 | TCU 33, Oklahoma State 33 | Box score |
| Sep 24, 1949 | Oregon 41, Idaho 0 | Box score |
| Sep 24, 1949 | Oregon State 27, Utah 7 | Box score |
| Sep 24, 1949 | Pittsburgh 13, William & Mary 7 | Box score |
| Sep 24, 1949 | Princeton 26, Lafayette 14 | Box score |
| Sep 24, 1949 | Rice 33, Clemson 7 | Box score |
| Sep 24, 1949 | USC 42, Navy 20 | Box score |
| Sep 24, 1949 | SMU 13, Wake Forest 7 | Box score |
| Sep 24, 1949 | Stanford 44, Harvard 0 | Box score |
| Sep 24, 1949 | Tennessee 10, Mississippi State 0 | Box score |
| Sep 24, 1949 | Texas 54, Temple 0 | Box score |
| Sep 24, 1949 | Texas A&M 26, Texas Tech 7upset | Box score |
| Sep 24, 1949 | Tulane 28, Alabama 14 | Box score |
| Sep 24, 1949 | UCLA 41, Iowa 25 | Box score |
| Sep 24, 1949 | Villanova 27, Penn State 6 | Box score |
| Sep 24, 1949 | Virginia 27, George Washington 13 | Box score |
| Sep 24, 1949 | Washington State 13, Montana 7 | Box score |
| Sep 24, 1949 | Wisconsin 41, Marquette 0 | Box score |
| Sep 24, 1949 | Wyoming 41, New Mexico 14 | Box score |