| Oct 7, 1949 | Alabama 48, Duquesne 8 | Box score |
| Oct 7, 1949 | San Francisco 38, Detroit Mercy 14upset | Box score |
| Oct 7, 1949 | Temple 27, Syracuse 14 | Box score |
| Oct 8, 1949 | 7Army 21, 1Michigan 7upset | Box score |
| Oct 8, 1949 | Baylor 35, Arkansas 13 | Box score |
| Oct 8, 1949 | Boston University 40, Colgate 21 | Box score |
| Oct 8, 1949 | 10California 35, Wisconsin 20 | Box score |
| Oct 8, 1949 | Colorado State 27, Montana 12 | Box score |
| Oct 8, 1949 | 17Cornell 33, Harvard 14 | Box score |
| Oct 8, 1949 | Dartmouth 31, Holy Cross 7 | Box score |
| Oct 8, 1949 | Davidson 20, NC State 14 | Box score |
| Oct 8, 1949 | Florida 14, Auburn 14 | Box score |
| Oct 8, 1949 | Georgetown 12, Wake Forest 6upset | Box score |
| Oct 8, 1949 | Georgia Tech 36, Washington and Lee 0 | Box score |
| Oct 8, 1949 | Hardin Simmons 35, Arizona 0 | Box score |
| Oct 8, 1949 | Illinois 20, Iowa 14 | Box score |
| Oct 8, 1949 | Iowa State 13, Colorado 6 | Box score |
| Oct 8, 1949 | Kansas 21, George Washington 14 | Box score |
| Oct 8, 1949 | 15Kentucky 25, Georgia 0 | Box score |
| Oct 8, 1949 | LSU 34, Texas A&M 0 | Box score |
| Oct 8, 1949 | Marquette 62, Saint Louis 7 | Box score |
| Oct 8, 1949 | Miami 26, Louisville 0 | Box score |
| Oct 8, 1949 | 13Michigan State 14, Maryland 7 | Box score |
| Oct 8, 1949 | 5Minnesota 21, 20Northwestern 7 | Box score |
| Oct 8, 1949 | Clemson 7, Mississippi State 7 | Box score |
| Oct 8, 1949 | 20Missouri 21, Oklahoma State 7 | Box score |
| Oct 8, 1949 | Navy 28, 14Duke 14upset | Box score |
| Oct 8, 1949 | Nebraska 13, Kansas State 6 | Box score |
| Oct 8, 1949 | 6North Carolina 28, South Carolina 13 | Box score |
| Oct 8, 1949 | 2Notre Dame 35, Purdue 12 | Box score |
| Oct 8, 1949 | 8USC 13, 11Ohio State 13 | Box score |
| Oct 8, 1949 | 3Oklahoma 20, 12Texas 14 | Box score |
| Oct 8, 1949 | Oregon 21, Washington State 0 | Box score |
| Oct 8, 1949 | Oregon State 7, Washington 3 | Box score |
| Oct 8, 1949 | Penn State 32, Boston College 14 | Box score |
| Oct 8, 1949 | 20Pennsylvania 14, Princeton 13 | Box score |
| Oct 8, 1949 | 19Pittsburgh 20, West Virginia 7 | Box score |
| Oct 8, 1949 | Rice 55, New Mexico 0 | Box score |
| Oct 8, 1949 | Richmond 12, Furman 0 | Box score |
| Oct 8, 1949 | TCU 13, Indiana 6 | Box score |
| Oct 8, 1949 | Texas Tech 15, Tulsa 0 | Box score |
| Oct 8, 1949 | UTEP 34, West Texas 7 | Box score |
| Oct 8, 1949 | 18UCLA 14, Stanford 7 | Box score |
| Oct 8, 1949 | Utah 38, BYU 0 | Box score |
| Oct 8, 1949 | Vanderbilt 28, Ole Miss 27 | Box score |
| Oct 8, 1949 | 16Villanova 28, Saint Mary’s (CA) 20 | Box score |
| Oct 8, 1949 | Virginia 26, Virginia Tech 0 | Box score |
| Oct 8, 1949 | Wichita State 21, Bradley 13 | Box score |
| Oct 8, 1949 | William & Mary 54, VMI 6 | Box score |
| Oct 8, 1949 | Yale 33, Columbia 7upset | Box score |