| Oct 14, 1949 | Boston University 52, West Virginia 20 | Box score |
| Oct 14, 1949 | Georgetown 21, New York University 6 | Box score |
| Oct 14, 1949 | Georgia 7, LSU 0 | Box score |
| Oct 14, 1949 | Boston College 25, Ole Miss 25 | Box score |
| Oct 14, 1949 | Purdue 14, Miami 0 | Box score |
| Oct 14, 1949 | Tulsa 21, 17Villanova 19upset | Box score |
| Oct 15, 1949 | Arizona State 49, BYU 21 | Box score |
| Oct 15, 1949 | 2Army 54, Harvard 14 | Box score |
| Oct 15, 1949 | 20Baylor 28, Texas Tech 7 | Box score |
| Oct 15, 1949 | 9California 16, 12USC 10 | Box score |
| Oct 15, 1949 | Cincinnati 19, Mississippi State 0 | Box score |
| Oct 15, 1949 | 14Cornell 48, Yale 14 | Box score |
| Oct 15, 1949 | Dartmouth 27, Colgate 13 | Box score |
| Oct 15, 1949 | Denver 20, Utah 18upset | Box score |
| Oct 15, 1949 | Duke 14, NC State 13 | Box score |
| Oct 15, 1949 | Duquesne 40, Holy Cross 14upset | Box score |
| Oct 15, 1949 | George Washington 24, Virginia Tech 14 | Box score |
| Oct 15, 1949 | Georgia Tech 35, Auburn 21 | Box score |
| Oct 15, 1949 | Hardin Simmons 34, New Mexico 7 | Box score |
| Oct 15, 1949 | Iowa 35, Indiana 9 | Box score |
| Oct 15, 1949 | Iowa State 25, Kansas State 21 | Box score |
| Oct 15, 1949 | 8Kentucky 44, The Citadel 0 | Box score |
| Oct 15, 1949 | Marquette 24, Detroit Mercy 14 | Box score |
| Oct 15, 1949 | 19Michigan State 42, William & Mary 13 | Box score |
| Oct 15, 1949 | 5Minnesota 27, 11Ohio State 0 | Box score |
| Oct 15, 1949 | Missouri 27, Illinois 20 | Box score |
| Oct 15, 1949 | Nevada 20, Wichita State 7 | Box score |
| Oct 15, 1949 | 6North Carolina 28, Wake Forest 14 | Box score |
| Oct 15, 1949 | Northwestern 21, 7Michigan 20upset | Box score |
| Oct 15, 1949 | 1Notre Dame 46, 4Tulane 7 | Box score |
| Oct 15, 1949 | 3Oklahoma 48, Kansas 26 | Box score |
| Oct 15, 1949 | Oklahoma State 28, Drake 0 | Box score |
| Oct 15, 1949 | Oregon 42, Colorado 14 | Box score |
| Oct 15, 1949 | Oregon State 63, Montana 14 | Box score |
| Oct 15, 1949 | Penn State 22, Nebraska 7 | Box score |
| Oct 15, 1949 | Pennsylvania 27, Columbia 7 | Box score |
| Oct 15, 1949 | 15Pittsburgh 35, Miami (OH) 26 | Box score |
| Oct 15, 1949 | Princeton 27, Brown 14 | Box score |
| Oct 15, 1949 | Rice 41, 10SMU 27upset | Box score |
| Oct 15, 1949 | Saint Louis 41, Davidson 12 | Box score |
| Oct 15, 1949 | Saint Mary’s (CA) 27, Loyola Marymount 14 | Box score |
| Oct 15, 1949 | Santa Clara 14, 13UCLA 0upset | Box score |
| Oct 15, 1949 | Stanford 40, Washington 0 | Box score |
| Oct 15, 1949 | Syracuse 21, Rutgers 9upset | Box score |
| Oct 15, 1949 | Tennessee 7, Alabama 7 | Box score |
| Oct 15, 1949 | 16Texas 27, Arkansas 14 | Box score |
| Oct 15, 1949 | TCU 28, Texas A&M 6 | Box score |
| Oct 15, 1949 | UTEP 28, Arizona 0 | Box score |
| Oct 15, 1949 | Vanderbilt 22, Florida 17 | Box score |
| Oct 15, 1949 | Virginia 27, Washington and Lee 7 | Box score |
| Oct 15, 1949 | VMI 14, Richmond 7 | Box score |
| Oct 15, 1949 | Washington State 35, Idaho 13 | Box score |
| Oct 15, 1949 | Wisconsin 48, 18Navy 13upset | Box score |
| Oct 15, 1949 | Wyoming 27, Utah State 0 | Box score |