| Oct 20, 1949 | South Carolina 27, Clemson 13upset | Box score |
| Oct 21, 1949 | Furman 19, The Citadel 7 | Box score |
| Oct 21, 1949 | George Washington 21, Washington and Lee 19 | Box score |
| Oct 21, 1949 | Georgetown 10, Boston College 7 | Box score |
| Oct 21, 1949 | Miami 13, Georgia 9upset | Box score |
| Oct 22, 1949 | Alabama 35, Mississippi State 6 | Box score |
| Oct 22, 1949 | Arkansas 7, Vanderbilt 6upset | Box score |
| Oct 22, 1949 | 2Army 63, Columbia 6 | Box score |
| Oct 22, 1949 | 11Baylor 21, Texas A&M 0 | Box score |
| Oct 22, 1949 | Boston University 38, New York University 0 | Box score |
| Oct 22, 1949 | 5California 21, Washington 7 | Box score |
| Oct 22, 1949 | Colorado 20, Utah State 7 | Box score |
| Oct 22, 1949 | 8Cornell 14, Princeton 12 | Box score |
| Oct 22, 1949 | Dartmouth 27, Harvard 13 | Box score |
| Oct 22, 1949 | Denver 35, BYU 7 | Box score |
| Oct 22, 1949 | Drake 27, Saint Louis 14 | Box score |
| Oct 22, 1949 | Duke 55, Virginia Tech 7 | Box score |
| Oct 22, 1949 | Fordham 47, Syracuse 21 | Box score |
| Oct 22, 1949 | Georgia Tech 43, Florida 14 | Box score |
| Oct 22, 1949 | Idaho 47, Montana 19 | Box score |
| Oct 22, 1949 | Illinois 19, Purdue 0 | Box score |
| Oct 22, 1949 | Indiana 48, 16Pittsburgh 14upset | Box score |
| Oct 22, 1949 | Iowa 28, 13Northwestern 21upset | Box score |
| Oct 22, 1949 | Kansas 55, Oklahoma State 14upset | Box score |
| Oct 22, 1949 | LSU 13, 6North Carolina 7upset | Box score |
| Oct 22, 1949 | Maryland 14, NC State 6 | Box score |
| Oct 22, 1949 | 12Michigan 14, 3Minnesota 7upset | Box score |
| Oct 22, 1949 | 15Michigan State 24, Penn State 0 | Box score |
| Oct 22, 1949 | 18Missouri 32, Iowa State 0 | Box score |
| Oct 22, 1949 | Ohio State 21, Wisconsin 0 | Box score |
| Oct 22, 1949 | 4Oklahoma 48, Nebraska 0 | Box score |
| Oct 22, 1949 | 14Pennsylvania 28, Navy 7 | Box score |
| Oct 22, 1949 | 9Rice 17, 10Texas 15 | Box score |
| Oct 22, 1949 | Richmond 28, Davidson 7 | Box score |
| Oct 22, 1949 | Rutgers 35, Colgate 13 | Box score |
| Oct 22, 1949 | San Francisco 41, Saint Mary’s (CA) 14 | Box score |
| Oct 22, 1949 | Santa Clara 27, Loyola Marymount 19 | Box score |
| Oct 22, 1949 | 19USC 40, Oregon 13 | Box score |
| Oct 22, 1949 | 17SMU 20, 7Kentucky 7upset | Box score |
| Oct 22, 1949 | Stanford 27, Oregon State 7 | Box score |
| Oct 22, 1949 | TCU 33, Ole Miss 27 | Box score |
| Oct 22, 1949 | Texas Tech 27, Arizona 7 | Box score |
| Oct 22, 1949 | UTEP 7, New Mexico 0 | Box score |
| Oct 22, 1949 | 20Tulane 14, Auburn 6 | Box score |
| Oct 22, 1949 | Tulsa 55, Bradley 6 | Box score |
| Oct 22, 1949 | UCLA 27, Washington State 20 | Box score |
| Oct 22, 1949 | Villanova 20, Duquesne 0 | Box score |
| Oct 22, 1949 | Virginia 32, VMI 13 | Box score |
| Oct 22, 1949 | Wake Forest 55, William & Mary 28 | Box score |
| Oct 22, 1949 | Wyoming 13, Utah 0 | Box score |
| Oct 22, 1949 | Yale 14, Holy Cross 7 | Box score |