| Oct 28, 1949 | Detroit Mercy 13, Oklahoma State 7 | Box score |
| Oct 28, 1949 | George Washington 14, Lafayette 7 | Box score |
| Oct 28, 1949 | Villanova 28, Boston College 14 | Box score |
| Oct 29, 1949 | Alabama 14, Georgia 7 | Box score |
| Oct 29, 1949 | Arizona State 28, New Mexico 19 | Box score |
| Oct 29, 1949 | Arkansas 27, Texas A&M 6 | Box score |
| Oct 29, 1949 | 2Army 40, VMI 14 | Box score |
| Oct 29, 1949 | 10Baylor 40, TCU 14 | Box score |
| Oct 29, 1949 | 4California 35, 20UCLA 21 | Box score |
| Oct 29, 1949 | Colorado 14, Utah 7 | Box score |
| Oct 29, 1949 | Colorado State 28, Utah State 6 | Box score |
| Oct 29, 1949 | 8Cornell 54, Columbia 0 | Box score |
| Oct 29, 1949 | Dartmouth 34, Yale 13 | Box score |
| Oct 29, 1949 | Denver 20, Arizona 6 | Box score |
| Oct 29, 1949 | Saint Mary’s (CA) 13, Drake 13 | Box score |
| Oct 29, 1949 | Duke 27, Georgia Tech 14upset | Box score |
| Oct 29, 1949 | Duquesne 51, Saint Louis 14 | Box score |
| Oct 29, 1949 | Florida 28, Furman 27 | Box score |
| Oct 29, 1949 | Fordham 42, Georgetown 0 | Box score |
| Oct 29, 1949 | Hardin Simmons 33, UTEP 14 | Box score |
| Oct 29, 1949 | Harvard 22, Holy Cross 14 | Box score |
| Oct 29, 1949 | Iowa 34, Oregon 31 | Box score |
| Oct 29, 1949 | Kansas 38, Kansas State 0 | Box score |
| Oct 29, 1949 | 14Kentucky 14, Cincinnati 7 | Box score |
| Oct 29, 1949 | 17LSU 34, Ole Miss 7 | Box score |
| Oct 29, 1949 | Louisville 35, Bradley 12upset | Box score |
| Oct 29, 1949 | Maryland 44, South Carolina 7 | Box score |
| Oct 29, 1949 | 6Michigan 13, Illinois 0 | Box score |
| Oct 29, 1949 | 12Michigan State 62, Temple 14 | Box score |
| Oct 29, 1949 | 16Missouri 21, Nebraska 20 | Box score |
| Oct 29, 1949 | NC State 14, Virginia Tech 13 | Box score |
| Oct 29, 1949 | 1Notre Dame 40, Navy 0 | Box score |
| Oct 29, 1949 | 18Ohio State 24, Northwestern 7 | Box score |
| Oct 29, 1949 | 3Oklahoma 34, Iowa State 7 | Box score |
| Oct 29, 1949 | Oregon State 35, Washington State 6 | Box score |
| Oct 29, 1949 | Penn State 33, Syracuse 21 | Box score |
| Oct 29, 1949 | Pittsburgh 22, 9Pennsylvania 21upset | Box score |
| Oct 29, 1949 | Princeton 34, Rutgers 14 | Box score |
| Oct 29, 1949 | Purdue 13, 7Minnesota 7upset | Box score |
| Oct 29, 1949 | 5Rice 28, Texas Tech 0 | Box score |
| Oct 29, 1949 | Stanford 7, Santa Clara 7 | Box score |
| Oct 29, 1949 | 15USC 40, Washington 28 | Box score |
| Oct 29, 1949 | 11SMU 7, 19Texas 6 | Box score |
| Oct 29, 1949 | Tennessee 35, 13North Carolina 6upset | Box score |
| Oct 29, 1949 | Tulane 54, Mississippi State 6 | Box score |
| Oct 29, 1949 | Vanderbilt 26, Auburn 7 | Box score |
| Oct 29, 1949 | Virginia 19, West Virginia 14 | Box score |
| Oct 29, 1949 | Wake Forest 35, Clemson 21 | Box score |
| Oct 29, 1949 | Washington and Lee 53, Davidson 0 | Box score |
| Oct 29, 1949 | Wichita State 27, Tulsa 21 | Box score |
| Oct 29, 1949 | William & Mary 34, Richmond 0 | Box score |
| Oct 29, 1949 | Wisconsin 30, Indiana 14 | Box score |
| Oct 29, 1949 | Wyoming 45, BYU 0 | Box score |
| Oct 30, 1949 | San Francisco 41, Nevada 13 | Box score |