| Nov 4, 1949 | Miami 27, Detroit Mercy 6 | Box score |
| Nov 5, 1949 | Arizona 46, New Mexico 14 | Box score |
| Nov 5, 1949 | Arizona State 68, New Mexico State 32 | Box score |
| Nov 5, 1949 | 2Army 35, 20Fordham 0 | Box score |
| Nov 5, 1949 | Auburn 25, Mississippi State 6 | Box score |
| Nov 5, 1949 | Boston College 40, Clemson 27 | Box score |
| Nov 5, 1949 | 18Boston University 28, Temple 7 | Box score |
| Nov 5, 1949 | Brown 14, Yale 0 | Box score |
| Nov 5, 1949 | 4California 33, Washington State 14 | Box score |
| Nov 5, 1949 | Colorado State 21, Utah 12 | Box score |
| Nov 5, 1949 | 7Cornell 33, Syracuse 7 | Box score |
| Nov 5, 1949 | Dartmouth 35, Columbia 14 | Box score |
| Nov 5, 1949 | Florida 28, Georgia 7 | Box score |
| Nov 5, 1949 | Georgia Tech 30, 14Tennessee 13upset | Box score |
| Nov 5, 1949 | Holy Cross 35, Colgate 27 | Box score |
| Nov 5, 1949 | Illinois 33, Indiana 14 | Box score |
| Nov 5, 1949 | Iowa State 21, Drake 8 | Box score |
| Nov 5, 1949 | Kansas 27, Nebraska 13 | Box score |
| Nov 5, 1949 | 17LSU 33, Vanderbilt 13 | Box score |
| Nov 5, 1949 | Loyola Marymount 39, Hardin Simmons 35upset | Box score |
| Nov 5, 1949 | Maryland 40, George Washington 14 | Box score |
| Nov 5, 1949 | 5Michigan 20, Purdue 12 | Box score |
| Nov 5, 1949 | Minnesota 55, 15Iowa 7upset | Box score |
| Nov 5, 1949 | Missouri 20, Colorado 13 | Box score |
| Nov 5, 1949 | Tulane 21, Navy 21 | Box score |
| Nov 5, 1949 | North Carolina 20, William & Mary 14 | Box score |
| Nov 5, 1949 | NC State 20, Richmond 6 | Box score |
| Nov 5, 1949 | 1Notre Dame 34, 10Michigan State 21 | Box score |
| Nov 5, 1949 | 11Ohio State 14, Pittsburgh 10 | Box score |
| Nov 5, 1949 | 3Oklahoma 39, Kansas State 0 | Box score |
| Nov 5, 1949 | Oregon State 35, Idaho 25 | Box score |
| Nov 5, 1949 | Penn State 34, West Virginia 14 | Box score |
| Nov 5, 1949 | Princeton 33, Harvard 13 | Box score |
| Nov 5, 1949 | 8Rice 14, Arkansas 0 | Box score |
| Nov 5, 1949 | Rutgers 14, Lafayette 0 | Box score |
| Nov 5, 1949 | Saint Mary’s (CA) 41, Denver 21 | Box score |
| Nov 5, 1949 | Santa Clara 13, San Francisco 7 | Box score |
| Nov 5, 1949 | South Carolina 6, Marquette 3 | Box score |
| Nov 5, 1949 | Texas A&M 27, 9SMU 27 | Box score |
| Nov 5, 1949 | Stanford 34, 12USC 13upset | Box score |
| Nov 5, 1949 | Texas 20, 6Baylor 0upset | Box score |
| Nov 5, 1949 | Texas Tech 13, UTEP 0upset | Box score |
| Nov 5, 1949 | Oklahoma State 13, Tulsa 13 | Box score |
| Nov 5, 1949 | Utah State 22, BYU 3 | Box score |
| Nov 5, 1949 | Villanova 29, Georgetown 14 | Box score |
| Nov 5, 1949 | 19Virginia 26, 20Pennsylvania 14 | Box score |
| Nov 5, 1949 | VMI 47, Davidson 6 | Box score |
| Nov 5, 1949 | Wake Forest 27, 16Duke 7upset | Box score |
| Nov 5, 1949 | Washington 28, Oregon 27upset | Box score |
| Nov 5, 1949 | Washington and Lee 6, Virginia Tech 6 | Box score |
| Nov 5, 1949 | Saint Louis 21, Wichita State 21 | Box score |
| Nov 5, 1949 | Wisconsin 14, Northwestern 6 | Box score |