| Nov 11, 1949 | Colorado State 16, BYU 14 | Box score |
| Nov 11, 1949 | Loyola Marymount 13, Nevada 12upset | Box score |
| Nov 11, 1949 | Miami 13, South Carolina 7 | Box score |
| Nov 12, 1949 | Alabama 20, Georgia Tech 7 | Box score |
| Nov 12, 1949 | Arizona State 34, Arizona 7 | Box score |
| Nov 12, 1949 | 2Army 14, Pennsylvania 13 | Box score |
| Nov 12, 1949 | Baylor 32, Wyoming 13 | Box score |
| Nov 12, 1949 | Boston College 20, Fordham 12 | Box score |
| Nov 12, 1949 | Brown 28, Harvard 14 | Box score |
| Nov 12, 1949 | 4California 41, Oregon 14 | Box score |
| Nov 12, 1949 | The Citadel 19, VMI 14upset | Box score |
| Nov 12, 1949 | Clemson 33, Duquesne 20 | Box score |
| Nov 12, 1949 | Dartmouth 16, 6Cornell 7upset | Box score |
| Nov 12, 1949 | Drake 7, Wichita State 6 | Box score |
| Nov 12, 1949 | Duke 35, George Washington 0 | Box score |
| Nov 12, 1949 | Furman 21, Davidson 6 | Box score |
| Nov 12, 1949 | Georgetown 28, Denver 13 | Box score |
| Nov 12, 1949 | Georgia 20, Auburn 20 | Box score |
| Nov 12, 1949 | 14Kentucky 35, Florida 0 | Box score |
| Nov 12, 1949 | 16LSU 34, Mississippi State 7 | Box score |
| Nov 12, 1949 | Maryland 14, 15Boston University 13upset | Box score |
| Nov 12, 1949 | 5Michigan 20, Indiana 7 | Box score |
| Nov 12, 1949 | 9Minnesota 24, Pittsburgh 7 | Box score |
| Nov 12, 1949 | Navy 34, Columbia 0 | Box score |
| Nov 12, 1949 | Nebraska 7, Iowa State 0upset | Box score |
| Nov 12, 1949 | New Mexico 17, Colorado 15upset | Box score |
| Nov 12, 1949 | NC State 27, 18Wake Forest 14upset | Box score |
| Nov 12, 1949 | Northwestern 39, Colgate 20 | Box score |
| Nov 12, 1949 | 1Notre Dame 42, North Carolina 6 | Box score |
| Nov 12, 1949 | 11Ohio State 30, Illinois 17 | Box score |
| Nov 12, 1949 | 3Oklahoma 27, Missouri 7 | Box score |
| Nov 12, 1949 | Oklahoma State 26, Kansas State 14 | Box score |
| Nov 12, 1949 | Oregon State 25, 8Michigan State 20upset | Box score |
| Nov 12, 1949 | Penn State 28, Temple 7 | Box score |
| Nov 12, 1949 | Princeton 21, Yale 13 | Box score |
| Nov 12, 1949 | Purdue 41, Marquette 7 | Box score |
| Nov 12, 1949 | 7Rice 13, Texas A&M 0 | Box score |
| Nov 12, 1949 | Rutgers 33, New York University 9 | Box score |
| Nov 12, 1949 | 20Santa Clara 19, Saint Mary’s (CA) 6 | Box score |
| Nov 12, 1949 | 12SMU 34, Arkansas 6 | Box score |
| Nov 12, 1949 | 17Stanford 63, Idaho 0 | Box score |
| Nov 12, 1949 | Syracuse 47, Holy Cross 13 | Box score |
| Nov 12, 1949 | Tennessee 35, Ole Miss 7 | Box score |
| Nov 12, 1949 | TCU 14, 13Texas 13upset | Box score |
| Nov 12, 1949 | West Virginia 13, UTEP 13 | Box score |
| Nov 12, 1949 | Tulane 41, Vanderbilt 14 | Box score |
| Nov 12, 1949 | Tulsa 10, San Francisco 0upset | Box score |
| Nov 12, 1949 | UCLA 47, Washington 26 | Box score |
| Nov 12, 1949 | Virginia Tech 28, Richmond 13upset | Box score |
| Nov 12, 1949 | West Texas 19, Hardin Simmons 7upset | Box score |
| Nov 12, 1949 | Wisconsin 35, Iowa 13 | Box score |
| Nov 13, 1949 | Detroit Mercy 31, Saint Louis 14 | Box score |