| Sep 29, 1961 | Detroit Mercy 34, Xavier 8 | Box score |
| Sep 29, 1961 | Miami 25, Penn State 8 | Box score |
| Sep 29, 1961 | USC 21, SMU 16 | Box score |
| Sep 29, 1961 | VMI 8, Richmond 6 | Box score |
| Sep 30, 1961 | Alabama 9, Tulane 0 | Box score |
| Sep 30, 1961 | Nebraska 14, Arizona 14 | Box score |
| Sep 30, 1961 | Arizona State 14, Colorado State 6 | Box score |
| Sep 30, 1961 | Arkansas 6, Tulsa 0 | Box score |
| Sep 30, 1961 | Army 31, Boston University 7 | Box score |
| Sep 30, 1961 | Auburn 24, Tennessee 21 | Box score |
| Sep 30, 1961 | Baylor 16, Pittsburgh 13 | Box score |
| Sep 30, 1961 | Bowling Green 28, Dayton 11 | Box score |
| Sep 30, 1961 | Colorado 24, Oklahoma State 0 | Box score |
| Sep 30, 1961 | Columbia 50, Brown 0 | Box score |
| Sep 30, 1961 | Cornell 34, Colgate 0 | Box score |
| Sep 30, 1961 | Duke 42, Virginia 0 | Box score |
| Sep 30, 1961 | Florida 3, Florida State 3 | Box score |
| Sep 30, 1961 | Georgia Tech 24, Rice 0 | Box score |
| Sep 30, 1961 | Idaho 27, San José State 18 | Box score |
| Sep 30, 1961 | Iowa 28, California 7 | Box score |
| Sep 30, 1961 | Kansas State 14, Air Force 12upset | Box score |
| Sep 30, 1961 | LSU 16, Texas A&M 7 | Box score |
| Sep 30, 1961 | Maryland 24, Clemson 21 | Box score |
| Sep 30, 1961 | Memphis 56, Hardin Simmons 0 | Box score |
| Sep 30, 1961 | Michigan 29, UCLA 6 | Box score |
| Sep 30, 1961 | Michigan State 20, Wisconsin 0 | Box score |
| Sep 30, 1961 | Ole Miss 20, Kentucky 6 | Box score |
| Sep 30, 1961 | Mississippi State 10, Houston 7 | Box score |
| Sep 30, 1961 | Missouri 6, Minnesota 0 | Box score |
| Sep 30, 1961 | Montana 40, New Mexico 8upset | Box score |
| Sep 30, 1961 | Navy 44, William & Mary 6 | Box score |
| Sep 30, 1961 | North Carolina 27, NC State 22 | Box score |
| Sep 30, 1961 | North Texas 41, BYU 30 | Box score |
| Sep 30, 1961 | Northwestern 45, Boston College 0 | Box score |
| Sep 30, 1961 | Notre Dame 19, Oklahoma 6 | Box score |
| Sep 30, 1961 | Rutgers 16, Princeton 13 | Box score |
| Sep 30, 1961 | South Carolina 10, Wake Forest 7 | Box score |
| Sep 30, 1961 | Stanford 34, Oregon State 0upset | Box score |
| Sep 30, 1961 | Syracuse 29, West Virginia 14 | Box score |
| Sep 30, 1961 | Texas 42, Texas Tech 14 | Box score |
| Sep 30, 1961 | Ohio State 7, TCU 7 | Box score |
| Sep 30, 1961 | Utah 14, Oregon 6 | Box score |
| Sep 30, 1961 | Utah State 34, Washington State 14 | Box score |
| Sep 30, 1961 | Vanderbilt 21, Georgia 0upset | Box score |
| Sep 30, 1961 | Villanova 20, Holy Cross 6 | Box score |
| Sep 30, 1961 | Washington 20, Illinois 7 | Box score |
| Sep 30, 1961 | West Texas 56, UTEP 27 | Box score |
| Sep 30, 1961 | Wichita State 21, Cincinnati 13 | Box score |
| Sep 30, 1961 | Kansas 6, Wyoming 6 | Box score |