| Oct 6, 1961 | Florida 14, Tulane 3 | Box score |
| Oct 6, 1961 | Navy 17, Miami 6 | Box score |
| Oct 6, 1961 | Penn State 32, Boston University 0 | Box score |
| Oct 7, 1961 | Alabama 35, Vanderbilt 6 | Box score |
| Oct 7, 1961 | Arizona 53, Hardin Simmons 7 | Box score |
| Oct 7, 1961 | Arkansas 28, TCU 3 | Box score |
| Oct 7, 1961 | BYU 7, Montana 6 | Box score |
| Oct 7, 1961 | Missouri 14, California 14 | Box score |
| Oct 7, 1961 | The Citadel 24, Richmond 6 | Box score |
| Oct 7, 1961 | Clemson 27, North Carolina 0 | Box score |
| Oct 7, 1961 | Colorado 20, Kansas 19 | Box score |
| Oct 7, 1961 | Dartmouth 30, Pennsylvania 0 | Box score |
| Oct 7, 1961 | Duke 23, Wake Forest 3 | Box score |
| Oct 7, 1961 | George Washington 30, VMI 6 | Box score |
| Oct 7, 1961 | Georgia 17, South Carolina 14 | Box score |
| Oct 7, 1961 | Harvard 14, Cornell 0 | Box score |
| Oct 7, 1961 | Holy Cross 20, Buffalo 8 | Box score |
| Oct 7, 1961 | Houston 21, Boston College 0 | Box score |
| Oct 7, 1961 | Iowa 35, USC 34 | Box score |
| Oct 7, 1961 | Iowa State 21, Oklahoma 15 | Box score |
| Oct 7, 1961 | Kentucky 14, Auburn 12upset | Box score |
| Oct 7, 1961 | LSU 10, Georgia Tech 0 | Box score |
| Oct 7, 1961 | Maryland 22, Syracuse 21 | Box score |
| Oct 7, 1961 | Memphis 28, Louisville 13 | Box score |
| Oct 7, 1961 | Michigan 38, Army 8 | Box score |
| Oct 7, 1961 | Michigan State 31, Stanford 3 | Box score |
| Oct 7, 1961 | Minnesota 14, Oregon 7 | Box score |
| Oct 7, 1961 | Ole Miss 33, Florida State 0 | Box score |
| Oct 7, 1961 | Nebraska 24, Kansas State 0 | Box score |
| Oct 7, 1961 | New Mexico 7, UTEP 6 | Box score |
| Oct 7, 1961 | North Texas 14, New Mexico State 14 | Box score |
| Oct 7, 1961 | NC State 21, Virginia 14 | Box score |
| Oct 7, 1961 | Northwestern 28, Illinois 7 | Box score |
| Oct 7, 1961 | Notre Dame 22, Purdue 20upset | Box score |
| Oct 7, 1961 | Ohio 14, Dayton 13 | Box score |
| Oct 7, 1961 | Ohio State 13, UCLA 3 | Box score |
| Oct 7, 1961 | Oklahoma State 26, Tulsa 0 | Box score |
| Oct 7, 1961 | Oregon State 44, Idaho 6 | Box score |
| Oct 7, 1961 | Princeton 30, Columbia 20 | Box score |
| Oct 7, 1961 | San José State 14, Colorado State 0 | Box score |
| Oct 7, 1961 | SMU 9, Air Force 7 | Box score |
| Oct 7, 1961 | Tennessee 17, Mississippi State 3 | Box score |
| Oct 7, 1961 | Texas 41, Washington State 8 | Box score |
| Oct 7, 1961 | Texas A&M 38, Texas Tech 7 | Box score |
| Oct 7, 1961 | Utah 28, Arizona State 26 | Box score |
| Oct 7, 1961 | Wyoming 6, Utah State 6 | Box score |
| Oct 7, 1961 | Washington 22, Pittsburgh 17 | Box score |
| Oct 7, 1961 | West Virginia 28, Virginia Tech 0upset | Box score |
| Oct 7, 1961 | Wichita State 41, West Texas 34 | Box score |
| Oct 7, 1961 | Wisconsin 6, Indiana 3 | Box score |
| Oct 7, 1961 | Xavier 17, Cincinnati 12 | Box score |
| Oct 7, 1961 | Yale 14, Brown 3 | Box score |