| Oct 13, 1961 | Colorado 9, Miami 7 | Box score |
| Oct 13, 1961 | Detroit Mercy 20, Boston College 3 | Box score |
| Oct 14, 1961 | Air Force 8, Cincinnati 6 | Box score |
| Oct 14, 1961 | Alabama 26, NC State 7 | Box score |
| Oct 14, 1961 | Arizona 15, Oregon 6 | Box score |
| Oct 14, 1961 | Arizona State 28, West Texas 11 | Box score |
| Oct 14, 1961 | Arkansas 23, Baylor 13 | Box score |
| Oct 14, 1961 | Army 10, Penn State 6upset | Box score |
| Oct 14, 1961 | California 21, Washington 14upset | Box score |
| Oct 14, 1961 | The Citadel 10, William & Mary 8 | Box score |
| Oct 14, 1961 | Colgate 15, Harvard 0upset | Box score |
| Oct 14, 1961 | Columbia 11, Yale 0upset | Box score |
| Oct 14, 1961 | Dartmouth 34, Brown 0 | Box score |
| Oct 14, 1961 | Dayton 7, Louisville 6upset | Box score |
| Oct 14, 1961 | Florida State 3, Georgia 0 | Box score |
| Oct 14, 1961 | Georgia Tech 21, Duke 0 | Box score |
| Oct 14, 1961 | Holy Cross 20, Boston University 7 | Box score |
| Oct 14, 1961 | Iowa 27, Indiana 8 | Box score |
| Oct 14, 1961 | Kansas 21, Iowa State 7 | Box score |
| Oct 14, 1961 | Kentucky 21, Kansas State 8 | Box score |
| Oct 14, 1961 | LSU 42, South Carolina 0 | Box score |
| Oct 14, 1961 | Memphis 21, Southern Miss 7 | Box score |
| Oct 14, 1961 | Michigan State 28, Michigan 0 | Box score |
| Oct 14, 1961 | Minnesota 10, Northwestern 3 | Box score |
| Oct 14, 1961 | Ole Miss 47, Houston 7 | Box score |
| Oct 14, 1961 | Missouri 10, Oklahoma State 0 | Box score |
| Oct 14, 1961 | Navy 31, Cornell 7 | Box score |
| Oct 14, 1961 | New Mexico State 70, Pacific 19 | Box score |
| Oct 14, 1961 | North Carolina 14, Maryland 8upset | Box score |
| Oct 14, 1961 | Notre Dame 30, USC 0 | Box score |
| Oct 14, 1961 | Ohio State 44, Illinois 0 | Box score |
| Oct 14, 1961 | Princeton 9, Pennsylvania 3 | Box score |
| Oct 14, 1961 | Purdue 19, Miami (OH) 6 | Box score |
| Oct 14, 1961 | Rice 19, Florida 10 | Box score |
| Oct 14, 1961 | Richmond 16, George Washington 15 | Box score |
| Oct 14, 1961 | Stanford 17, San José State 6 | Box score |
| Oct 14, 1961 | Syracuse 28, Nebraska 6 | Box score |
| Oct 14, 1961 | Tennessee 52, Tulsa 6 | Box score |
| Oct 14, 1961 | Texas 28, Oklahoma 7 | Box score |
| Oct 14, 1961 | Texas Tech 10, TCU 0 | Box score |
| Oct 14, 1961 | Tulane 27, Virginia Tech 14 | Box score |
| Oct 14, 1961 | UCLA 28, Vanderbilt 21 | Box score |
| Oct 14, 1961 | Utah 21, BYU 20 | Box score |
| Oct 14, 1961 | Utah State 41, New Mexico 7 | Box score |
| Oct 14, 1961 | Villanova 28, Buffalo 6 | Box score |
| Oct 14, 1961 | Virginia 14, VMI 7upset | Box score |
| Oct 14, 1961 | Wake Forest 17, Clemson 13upset | Box score |
| Oct 14, 1961 | Washington State 34, Idaho 0 | Box score |
| Oct 14, 1961 | West Virginia 20, Pittsburgh 6upset | Box score |
| Oct 14, 1961 | Wichita State 26, North Texas 14 | Box score |
| Oct 14, 1961 | Wisconsin 23, Oregon State 20 | Box score |
| Oct 14, 1961 | Wyoming 18, Colorado State 7 | Box score |
| Oct 14, 1961 | Xavier 6, Ohio 3upset | Box score |