| Oct 20, 1961 | George Washington 49, William & Mary 12 | Box score |
| Oct 20, 1961 | Navy 37, Detroit Mercy 19 | Box score |
| Oct 21, 1961 | Alabama 34, Tennessee 3 | Box score |
| Oct 21, 1961 | Arizona 22, New Mexico 21 | Box score |
| Oct 21, 1961 | Arizona State 24, Oregon State 23 | Box score |
| Oct 21, 1961 | Army 51, Idaho 7 | Box score |
| Oct 21, 1961 | Boston College 22, Villanova 6 | Box score |
| Oct 21, 1961 | Boston University 12, West Virginia 6 | Box score |
| Oct 21, 1961 | Clemson 17, Duke 7 | Box score |
| Oct 21, 1961 | Colgate 15, Princeton 0upset | Box score |
| Oct 21, 1961 | Colorado 13, Kansas State 0 | Box score |
| Oct 21, 1961 | Columbia 26, Harvard 14 | Box score |
| Oct 21, 1961 | Florida 7, Vanderbilt 0 | Box score |
| Oct 21, 1961 | Florida State 13, Richmond 7 | Box score |
| Oct 21, 1961 | Georgia 10, Mississippi State 7 | Box score |
| Oct 21, 1961 | Georgia Tech 7, Auburn 6 | Box score |
| Oct 21, 1961 | Holy Cross 17, Dartmouth 13 | Box score |
| Oct 21, 1961 | Houston 13, Cincinnati 7 | Box score |
| Oct 21, 1961 | Indiana 33, Washington State 7 | Box score |
| Oct 21, 1961 | Iowa 47, Wisconsin 15 | Box score |
| Oct 21, 1961 | Kansas 10, Oklahoma 0 | Box score |
| Oct 21, 1961 | LSU 24, Kentucky 14 | Box score |
| Oct 21, 1961 | Maryland 21, Air Force 0 | Box score |
| Oct 21, 1961 | Michigan 16, Purdue 14 | Box score |
| Oct 21, 1961 | Michigan State 17, Notre Dame 7 | Box score |
| Oct 21, 1961 | Minnesota 33, Illinois 0 | Box score |
| Oct 21, 1961 | Ole Miss 41, Tulane 0 | Box score |
| Oct 21, 1961 | Missouri 13, Iowa State 7 | Box score |
| Oct 21, 1961 | North Carolina 17, South Carolina 0 | Box score |
| Oct 21, 1961 | NC State 7, Wake Forest 0 | Box score |
| Oct 21, 1961 | North Texas 23, Tulsa 12 | Box score |
| Oct 21, 1961 | Ohio State 10, Northwestern 0 | Box score |
| Oct 21, 1961 | Oklahoma State 14, Nebraska 6 | Box score |
| Oct 21, 1961 | Oregon 21, San José State 6 | Box score |
| Oct 21, 1961 | Penn State 14, Syracuse 0 | Box score |
| Oct 21, 1961 | Pennsylvania 7, Brown 0 | Box score |
| Oct 21, 1961 | Rice 10, SMU 0 | Box score |
| Oct 21, 1961 | USC 28, California 14 | Box score |
| Oct 21, 1961 | Texas 33, Arkansas 7 | Box score |
| Oct 21, 1961 | TCU 15, Texas A&M 14 | Box score |
| Oct 21, 1961 | Texas Tech 19, Baylor 17 | Box score |
| Oct 21, 1961 | UCLA 20, Pittsburgh 6 | Box score |
| Oct 21, 1961 | Utah 24, Montana 12 | Box score |
| Oct 21, 1961 | Utah State 49, Colorado State 3 | Box score |
| Oct 21, 1961 | Virginia Tech 20, Virginia 0 | Box score |
| Oct 21, 1961 | Washington 13, Stanford 0 | Box score |
| Oct 21, 1961 | West Texas 42, Hardin Simmons 0 | Box score |
| Oct 21, 1961 | Wichita State 42, New Mexico State 27 | Box score |
| Oct 21, 1961 | Wyoming 36, BYU 8 | Box score |
| Oct 21, 1961 | Xavier 14, Dayton 0 | Box score |
| Oct 21, 1961 | Yale 12, Cornell 0 | Box score |