1921: Week 9
60 games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 8, 1921 | Notre Dame 48, Rutgers 0 | Box score |
| Nov 10, 1921 | Clemson 7, The Citadel 7 | Box score |
| Nov 11, 1921 | Birmingham-Southern 14, Chattanooga 7 | Box score |
| Nov 11, 1921 | Duke 17, Wake Forest 0 | Box score |
| Nov 11, 1921 | Florida 9, Alabama 2upset | Box score |
| Nov 11, 1921 | Idaho 31, Wyoming 3 | Box score |
| Nov 11, 1921 | Iowa State 7, Kansas State 0 | Box score |
| Nov 11, 1921 | Texas 54, Mississippi State 7 | Box score |
| Nov 11, 1921 | Rice 7, Texas A&M 7 | Box score |
| Nov 11, 1921 | Virginia Tech 7, NC State 3 | Box score |
| Nov 12, 1921 | California 72, Washington 3 | Box score |
| Nov 12, 1921 | Centre 21, Auburn 0 | Box score |
| Nov 12, 1921 | Chicago 14, Illinois 6 | Box score |
| Nov 12, 1921 | Utah 0, Colorado 0 | Box score |
| Nov 12, 1921 | Colorado School of Mines 7, Colorado College 0 | Box score |
| Nov 12, 1921 | Erskine 18, Newberry 13 | Box score |
| Nov 12, 1921 | Furman 7, South Carolina 0 | Box score |
| Nov 12, 1921 | Georgia Tech 21, Georgetown 7 | Box score |
| Nov 12, 1921 | Harvard 9, Brown 7 | Box score |
| Nov 12, 1921 | Iowa 41, Indiana 0 | Box score |
| Nov 12, 1921 | Kentucky 14, VMI 7 | Box score |
| Nov 12, 1921 | LSU 21, Ole Miss 0 | Box score |
| Nov 12, 1921 | Wisconsin 7, Michigan 7 | Box score |
| Nov 12, 1921 | Missouri 24, Oklahoma 14 | Box score |
| Nov 12, 1921 | Nebraska 28, Kansas 0 | Box score |
| Nov 12, 1921 | Stanford 14, Nevada 14 | Box score |
| Nov 12, 1921 | North Carolina 0, Davidson 0 | Box score |
| Nov 12, 1921 | Oglethorpe 7, Mercer 6 | Box score |
| Nov 12, 1921 | Ohio State 28, Purdue 0 | Box score |
| Nov 12, 1921 | Penn State 13, Navy 7 | Box score |
| Nov 12, 1921 | Pennsylvania 14, Dartmouth 14 | Box score |
| Nov 12, 1921 | Arkansas 0, Phillips 0 | Box score |
| Nov 12, 1921 | Syracuse 14, Colgate 0 | Box score |
| Nov 12, 1921 | Tennessee 21, Sewanee 0 | Box score |
| Nov 12, 1921 | TCU 13, SMU 6 | Box score |
| Nov 12, 1921 | Washington & Jefferson 7, Pittsburgh 0 | Box score |
| Nov 12, 1921 | Washington St. Louis 14, Tulane 6 | Box score |
| Nov 12, 1921 | Washington State 7, Oregon State 3 | Box score |
| Nov 12, 1921 | West Virginia 7, Virginia 0 | Box score |
| Nov 12, 1921 | Yale 13, Princeton 7 | Box score |
| Nov 13, 1921 | Vanderbilt 7, Georgia 7 | Box score |
Everyone else
| Nov 12, 1921 | Austin 17, Southwestern U 10 | Box score |
| Nov 12, 1921 | Baylor 21, Hardin Simmons 0 | Box score |
| Nov 12, 1921 | Cornell 14, Springfield 0 | Box score |
| Nov 12, 1921 | Drake 30, Morningside 10 | Box score |
| Nov 12, 1921 | Oklahoma State 7, Emporia State 7 | Box score |
| Nov 12, 1921 | Grinnell 13, Cornell (IA) 6 | Box score |
| Nov 12, 1921 | Lafayette 44, Delaware 0 | Box score |
| Nov 12, 1921 | Lehigh 55, Lebanon Valley 7 | Box score |
| Nov 12, 1921 | Maryland 16, Catholic 0 | Box score |
| Nov 12, 1921 | Mississippi College 56, Millsaps 0 | Box score |
| Nov 12, 1921 | Notre Dame 42, Haskell 7 | Box score |
| Nov 12, 1921 | Ohio 23, Columbia 21upset | Box score |
| Nov 12, 1921 | Oregon 21, Multnomah A.C. 7 | Box score |
| Nov 12, 1921 | Presbyterian 27, Wofford 0 | Box score |
| Nov 12, 1921 | Richmond 49, Randolph Macon 0 | Box score |
| Nov 12, 1921 | Rutgers 21, New York University 7 | Box score |
| Nov 12, 1921 | Spring Hill 7, Samford 0 | Box score |
| Nov 12, 1921 | Utah State 20, Albertson 0 | Box score |
| Nov 12, 1921 | Washington and Lee 41, Roanoke 0 | Box score |