1921: Week 10
43 games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 18, 1921 | Erskine 13, Clemson 0upset | Box score |
| Nov 18, 1921 | Florida 7, Mississippi College 7 | Box score |
| Nov 19, 1921 | Arkansas 13, Baylor 12 | Box score |
| Nov 19, 1921 | Brown 7, Colgate 0 | Box score |
| Nov 19, 1921 | California 42, Stanford 7 | Box score |
| Nov 19, 1921 | Centre 25, Washington and Lee 0 | Box score |
| Nov 19, 1921 | Chicago 3, Wisconsin 0 | Box score |
| Nov 19, 1921 | Colorado 10, Colorado State 0upset | Box score |
| Nov 19, 1921 | Denver 13, Colorado School of Mines 7 | Box score |
| Nov 19, 1921 | Drake 21, Grinnell 10 | Box score |
| Nov 19, 1921 | Georgia 22, Alabama 0 | Box score |
| Nov 19, 1921 | Harvard 10, Yale 3 | Box score |
| Nov 19, 1921 | Illinois 7, Ohio State 0upset | Box score |
| Nov 19, 1921 | Indiana 3, Purdue 0 | Box score |
| Nov 19, 1921 | Iowa 14, Northwestern 0 | Box score |
| Nov 19, 1921 | Kansas State 14, Oklahoma 7 | Box score |
| Nov 19, 1921 | Mercer 18, Chattanooga 0 | Box score |
| Nov 19, 1921 | Michigan 38, Minnesota 0 | Box score |
| Nov 19, 1921 | Nebraska 35, Iowa State 3 | Box score |
| Nov 19, 1921 | NC State 14, Wake Forest 0 | Box score |
| Nov 19, 1921 | Oklahoma State 7, Phillips 6 | Box score |
| Nov 19, 1921 | Oregon 0, Oregon State 0 | Box score |
| Nov 19, 1921 | Rutgers 17, West Virginia 7upset | Box score |
| Nov 19, 1921 | South Carolina 13, The Citadel 0 | Box score |
| Nov 19, 1921 | SMU 0, Southwestern U 0 | Box score |
| Nov 19, 1921 | Syracuse 14, Dartmouth 7 | Box score |
| Nov 19, 1921 | Tulane 21, LSU 0 | Box score |
| Nov 19, 1921 | Vanderbilt 9, Sewanee 0 | Box score |
Everyone else
| Nov 18, 1921 | Rice 28, Trinity (Texas) 14 | Box score |
| Nov 19, 1921 | Carnegie Mellon 21, Maryland 0upset | Box score |
| Nov 19, 1921 | Davidson 47, Elon 0 | Box score |
| Nov 19, 1921 | Furman 62, Wofford 0 | Box score |
| Nov 19, 1921 | Haskell 14, TCU 0upset | Box score |
| Nov 19, 1921 | Idaho 6, Gonzaga 0 | Box score |
| Nov 19, 1921 | Lafayette 28, Lehigh 6 | Box score |
| Nov 19, 1921 | Newberry 16, Presbyterian 7 | Box score |
| Nov 19, 1921 | Notre Dame 21, Marquette 7 | Box score |
| Nov 19, 1921 | Rollins 3, Birmingham-Southern 0upset | Box score |
| Nov 19, 1921 | Samford 21, Marion 0 | Box score |
| Nov 19, 1921 | Tennessee Medical College 24, Ole Miss 6upset | Box score |
| Nov 19, 1921 | Virginia Tech 35, Roanoke 0 | Box score |
| Nov 19, 1921 | Washington & Jefferson 14, Detroit Mercy 2 | Box score |
| Nov 19, 1921 | Washington St. Louis 0, Saint Louis 0 | Box score |