1921: Week 8
57 games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 5, 1921 | Auburn 14, Tulane 0 | Box score |
| Nov 5, 1921 | Centre 55, Kentucky 0 | Box score |
| Nov 5, 1921 | Newberry 7, The Citadel 7 | Box score |
| Nov 5, 1921 | Colorado 35, Colorado College 14 | Box score |
| Nov 5, 1921 | Cornell 41, Columbia 7 | Box score |
| Nov 5, 1921 | Denver 21, Colorado State 14upset | Box score |
| Nov 5, 1921 | Furman 37, Mercer 0 | Box score |
| Nov 5, 1921 | Georgia Tech 48, Clemson 7 | Box score |
| Nov 5, 1921 | Idaho 35, Montana 7 | Box score |
| Nov 5, 1921 | Iowa 41, Minnesota 7 | Box score |
| Nov 5, 1921 | Iowa State 7, Drake 0 | Box score |
| Nov 5, 1921 | Kansas State 21, Grinnell 7 | Box score |
| Nov 5, 1921 | Lafayette 38, Pennsylvania 6 | Box score |
| Nov 5, 1921 | LSU 10, Arkansas 7 | Box score |
| Nov 5, 1921 | Mississippi College 27, Ole Miss 7 | Box score |
| Nov 5, 1921 | Missouri 7, Washington St. Louis 0 | Box score |
| Nov 5, 1921 | Navy 6, Bucknell 0 | Box score |
| Nov 5, 1921 | Nebraska 10, Pittsburgh 0upset | Box score |
| Nov 5, 1921 | Nevada 28, Utah 7 | Box score |
| Nov 5, 1921 | North Carolina 20, VMI 7upset | Box score |
| Nov 5, 1921 | NC State 3, Davidson 3 | Box score |
| Nov 5, 1921 | Notre Dame 28, Army 0 | Box score |
| Nov 5, 1921 | Ohio State 7, Chicago 0 | Box score |
| Nov 5, 1921 | Oklahoma 24, Kansas 7 | Box score |
| Nov 5, 1921 | Washington State 7, Oregon 7 | Box score |
| Nov 5, 1921 | Princeton 10, Harvard 3 | Box score |
| Nov 5, 1921 | Purdue 3, Northwestern 0 | Box score |
| Nov 5, 1921 | Rice 7, SMU 0 | Box score |
| Nov 5, 1921 | Richmond 41, Wake Forest 0 | Box score |
| Nov 5, 1921 | Sewanee 47, Chattanooga 0 | Box score |
| Nov 5, 1921 | South Carolina 7, Florida 7 | Box score |
| Nov 5, 1921 | Washington 0, Stanford 0 | Box score |
| Nov 5, 1921 | Tennessee 14, Mississippi State 7 | Box score |
| Nov 5, 1921 | Texas 44, Southwestern U 0 | Box score |
| Nov 5, 1921 | Texas A&M 14, Baylor 3 | Box score |
| Nov 5, 1921 | Utah State 23, Colorado School of Mines 7 | Box score |
| Nov 5, 1921 | Vanderbilt 14, Alabama 0 | Box score |
| Nov 5, 1921 | West Virginia 28, Washington and Lee 7 | Box score |
| Nov 5, 1921 | Yale 28, Maryland 0 | Box score |
| Nov 6, 1921 | Georgia 21, Virginia 0 | Box score |
Everyone else
| Nov 3, 1921 | Erskine 19, Wofford 6 | Box score |
| Nov 5, 1921 | Birmingham-Southern 16, Samford 14 | Box score |
| Nov 5, 1921 | Brown 55, St. Bonaventure 0 | Box score |
| Nov 5, 1921 | California 38, USC 7 | Box score |
| Nov 5, 1921 | Central Oklahoma 28, Phillips 3upset | Box score |
| Nov 5, 1921 | Colgate 41, Rochester (NY) 0 | Box score |
| Nov 5, 1921 | Creighton 26, Oklahoma State 13 | Box score |
| Nov 5, 1921 | Fort Benning 18, Presbyterian 0 | Box score |
| Nov 5, 1921 | Illinois 21, DePauw 0 | Box score |
| Nov 5, 1921 | Muhlenberg 14, Lehigh 13upset | Box score |
| Nov 5, 1921 | Oglethorpe 41, Stetson 0 | Box score |
| Nov 5, 1921 | Penn State 28, Carnegie Mellon 7 | Box score |
| Nov 5, 1921 | Spring Hill 84, Jefferson 6 | Box score |
| Nov 5, 1921 | Syracuse 13, McGill 0 | Box score |
| Nov 5, 1921 | TCU 7, American Osteopath 0 | Box score |
| Nov 5, 1921 | Virginia Tech 54, Morris Harvey 7 | Box score |
| Nov 5, 1921 | Washington & Jefferson 49, Westminster (Pennsylvania) 14 | Box score |