| Oct 22, 2021 | Columbia 19, Dartmouth 0upset | Box score |
| Oct 23, 2021 | Arkansas 45, Arkansas–Pine Bluff 3 | Box score |
| Oct 23, 2021 | Yale 42, Pennsylvania 28 | Box score |
| Oct 23, 2021 | Morehead State 27, Marist 24 | Box score |
| Oct 23, 2021 | Seton Hill 49, Clarion 0 | Box score |
| Oct 23, 2021 | Shepherd 42, West Chester 38 | Box score |
| Oct 23, 2021 | Slippery Rock 20, Mercyhurst 17 | Box score |
| Oct 23, 2021 | Tiffin 34, Kentucky Wesleyan 28 | Box score |
| Oct 23, 2021 | Wingate 48, UVA Wise 21 | Box score |
| Oct 23, 2021 | Minot State 17, Upper Iowa 14 | Box score |
| Oct 23, 2021 | Gannon 21, Edinboro 18 | Box score |
| Oct 23, 2021 | Hillsdale 34, Findlay 29upset | Box score |
| Oct 23, 2021 | Sacred Heart 31, Duquesne 13 | Box score |
| Oct 23, 2021 | Bryant 31, Wagner 10 | Box score |
| Oct 23, 2021 | Long Island University 30, Central Connecticut 13upset | Box score |
| Oct 23, 2021 | Ohio Dominican 56, Walsh 17 | Box score |
| Oct 23, 2021 | Bowie State 27, Virginia Union 7 | Box score |
| Oct 23, 2021 | Fayetteville State 40, St. Augustine’s 12 | Box score |
| Oct 23, 2021 | Shaw 20, Johnson C. Smith 14 | Box score |
| Oct 23, 2021 | Maine 19, UAlbany 16 | Box score |
| Oct 23, 2021 | Elon 24, New Hampshire 10 | Box score |
| Oct 23, 2021 | Brown 49, Cornell 45upset | Box score |
| Oct 23, 2021 | Winston-Salem State 21, Livingstone 0 | Box score |
| Oct 23, 2021 | North Carolina Central 28, Morgan State 17 | Box score |
| Oct 23, 2021 | Norfolk State 45, Howard 31 | Box score |
| Oct 23, 2021 | Indiana State 28, Youngstown State 17 | Box score |
| Oct 23, 2021 | Georgetown 29, Bucknell 21 | Box score |
| Oct 23, 2021 | Davidson 49, Butler 35 | Box score |
| Oct 23, 2021 | Valparaiso 45, Dayton 28upset | Box score |
| Oct 23, 2021 | Chattanooga 55, Samford 13 | Box score |
| Oct 23, 2021 | McNeese 28, Incarnate Word 20 | Box score |
| Oct 23, 2021 | Ashland 42, Lake Erie 41 | Box score |
| Oct 23, 2021 | Davenport 21, Northwood 14 | Box score |
| Oct 23, 2021 | Ferris State 38, Michigan Tech 10 | Box score |
| Oct 23, 2021 | New Haven 42, Stonehill 20 | Box score |
| Oct 23, 2021 | Grand Valley State 28, Northern Michigan 24 | Box score |
| Oct 23, 2021 | Miles 28, Kentucky State 21upset | Box score |
| Oct 23, 2021 | Minnesota St Moorhead 35, University of Mary 31 | Box score |
| Oct 23, 2021 | Northern State 38, Concordia St. Paul 17 | Box score |
| Oct 23, 2021 | Shippensburg 38, Millersville 7 | Box score |
| Oct 23, 2021 | Mars Hill 31, Catawba 14 | Box score |
| Oct 23, 2021 | Alderson-Broaddus 49, West Virginia Wesleyan 20 | Box score |
| Oct 23, 2021 | Stetson 1, Drake 0upset | Box score |
| Oct 23, 2021 | West Virginia State 34, Concord 32 | Box score |
| Oct 23, 2021 | Southern Connecticut State 43, Franklin Pierce 24 | Box score |
| Oct 23, 2021 | San Diego 69, Presbyterian 28 | Box score |
| Oct 23, 2021 | Wheeling 26, West Liberty 20 | Box score |
| Oct 23, 2021 | Fordham 35, Lehigh 28 | Box score |
| Oct 23, 2021 | Frostburg State 49, Fairmont State 14 | Box score |
| Oct 23, 2021 | Princeton 18, Harvard 16 | Box score |
| Oct 23, 2021 | Assumption 42, American International 21 | Box score |
| Oct 23, 2021 | East Stroudsburg 35, Bloomsburg 14 | Box score |
| Oct 23, 2021 | Elizabeth City State 32, Chowan 28 | Box score |
| Oct 23, 2021 | Gardner-Webb 28, Robert Morris 17 | Box score |
| Oct 23, 2021 | Notre Dame College 34, Glenville State 14 | Box score |
| Oct 23, 2021 | Virginia State 23, Lincoln (PA) 3 | Box score |
| Oct 23, 2021 | Hampton 30, North Carolina A&T 9upset | Box score |
| Oct 23, 2021 | South Carolina State 13, Delaware State 7 | Box score |
| Oct 23, 2021 | Illinois State 20, South Dakota 14upset | Box score |
| Oct 23, 2021 | Ouachita Baptist 42, Southern Arkansas 7 | Box score |
| Oct 23, 2021 | Western Carolina 45, The Citadel 31upset | Box score |
| Oct 23, 2021 | East Tennessee State 17, Furman 13 | Box score |
| Oct 23, 2021 | Lindenwood 48, Southwest Baptist 24 | Box score |
| Oct 23, 2021 | Jackson State 42, Bethune-Cookman 12 | Box score |
| Oct 23, 2021 | Missouri S&T 37, McKendree 31 | Box score |
| Oct 23, 2021 | Albany State 30, Savannah State 0 | Box score |
| Oct 23, 2021 | Winona State 14, Sioux Falls 10 | Box score |
| Oct 23, 2021 | Morehouse 20, Benedict 5 | Box score |
| Oct 23, 2021 | Fort Valley State 40, Clark Atlanta 7 | Box score |
| Oct 23, 2021 | Edward Waters 56, Central State 19 | Box score |
| Oct 23, 2021 | Lane College 21, Tuskegee 17 | Box score |
| Oct 23, 2021 | Augustana (SD) 45, Minnesota State 35 | Box score |
| Oct 23, 2021 | California (PA) 38, IU Pennsylvania 34 | Box score |
| Oct 23, 2021 | Kutztown 32, Lock Haven 15 | Box score |
| Oct 23, 2021 | Chadron State 60, Fort Lewis 7 | Box score |
| Oct 23, 2021 | Western Colorado 42, South Dakota Mines 21 | Box score |
| Oct 23, 2021 | Texas A&M–Kingsville 28, Western New Mexico 19 | Box score |
| Oct 23, 2021 | Northwest Missouri State 59, Northeastern State 7 | Box score |
| Oct 23, 2021 | Lenoir Rhyne 45, Limestone 3 | Box score |
| Oct 23, 2021 | Indianapolis 70, Quincy 21 | Box score |
| Oct 23, 2021 | Saint Anselm 24, Pace 16 | Box score |
| Oct 23, 2021 | Tusculum 41, Barton 17 | Box score |
| Oct 23, 2021 | UNC Pembroke 21, Charleston (WV) 14 | Box score |
| Oct 23, 2021 | Tennessee Tech 56, Virginia Lynchburg 13 | Box score |
| Oct 23, 2021 | Fort Hays 21, Central Missouri 17 | Box score |
| Oct 23, 2021 | Sam Houston 42, Jacksonville State 7 | Box score |
| Oct 23, 2021 | Montana State 27, Idaho State 9 | Box score |
| Oct 23, 2021 | North Alabama 45, Charleston Southern 22 | Box score |
| Oct 23, 2021 | James Madison 22, Delaware 10 | Box score |
| Oct 23, 2021 | Henderson State 41, Arkansas Tech 38 | Box score |
| Oct 23, 2021 | East Central 44, Southwestern Oklahoma State 34 | Box score |
| Oct 23, 2021 | North Dakota 34, Western Illinois 10 | Box score |
| Oct 23, 2021 | Northern Iowa 26, South Dakota State 17upset | Box score |
| Oct 23, 2021 | Austin Peay 47, Murray State 6 | Box score |
| Oct 23, 2021 | Tennessee State 28, Eastern Illinois 0 | Box score |
| Oct 23, 2021 | UT Martin 38, Southeast Missouri State 30 | Box score |
| Oct 23, 2021 | Truman State 52, William Jewell 0 | Box score |
| Oct 23, 2021 | Saginaw Valley State 41, Wayne State (MI) 25 | Box score |
| Oct 23, 2021 | Valdosta State 41, Mississippi College 14 | Box score |
| Oct 23, 2021 | New Mexico Highlands 24, Black Hills State 10 | Box score |
| Oct 23, 2021 | Colorado Mesa 26, Colorado School of Mines 21 | Box score |
| Oct 23, 2021 | Washburn 29, Central Oklahoma 17 | Box score |
| Oct 23, 2021 | Emporia State 24, Missouri Southern State 21 | Box score |
| Oct 23, 2021 | Bemidji State 42, Minnesota Duluth 35upset | Box score |
| Oct 23, 2021 | Villanova 44, Rhode Island 0 | Box score |
| Oct 23, 2021 | Stony Brook 27, Richmond 14 | Box score |
| Oct 23, 2021 | William & Mary 40, Towson 14 | Box score |
| Oct 23, 2021 | North Dakota State 27, Missouri State 20 | Box score |
| Oct 23, 2021 | Weber State 35, Eastern Washington 34upset | Box score |
| Oct 23, 2021 | Kennesaw State 30, Campbell 7 | Box score |
| Oct 23, 2021 | Harding 64, Arkansas Monticello 7 | Box score |
| Oct 23, 2021 | SE Louisiana 51, Northwestern State 14 | Box score |
| Oct 23, 2021 | Florida A&M 31, Mississippi Valley State 28 | Box score |
| Oct 23, 2021 | CSU Pueblo 35, Adams State 28 | Box score |
| Oct 23, 2021 | Newberry 34, Carson Newman 3 | Box score |
| Oct 23, 2021 | Erskine 47, Allen 40 | Box score |
| Oct 23, 2021 | Holy Cross 42, Colgate 10 | Box score |
| Oct 23, 2021 | Delta State 35, West Alabama 30upset | Box score |
| Oct 23, 2021 | Pittsburg State 34, Missouri Western 14 | Box score |
| Oct 23, 2021 | Mercer 45, Wofford 14 | Box score |
| Oct 23, 2021 | West Georgia 34, North Greenville 12 | Box score |
| Oct 23, 2021 | Wayne State (NE) 38, Southwest Minnesota State 16 | Box score |
| Oct 23, 2021 | Central Arkansas 49, Lamar 38 | Box score |
| Oct 23, 2021 | Tarleton State 17, Midwestern State 14 | Box score |
| Oct 23, 2021 | Oklahoma Baptist 43, Southeastern Oklahoma State 37 | Box score |
| Oct 23, 2021 | Nicholls 44, Houston Christian 14 | Box score |
| Oct 23, 2021 | Prairie View A&M 48, Southern 21 | Box score |
| Oct 23, 2021 | Angelo State 51, Simon Fraser 10 | Box score |
| Oct 23, 2021 | East Texas A&M 15, West Texas 3upset | Box score |
| Oct 23, 2021 | UT Permian Basin 44, Eastern New Mexico 21 | Box score |
| Oct 23, 2021 | Montana 34, Idaho 14 | Box score |
| Oct 23, 2021 | UC Davis 24, Cal Poly 13 | Box score |
| Oct 23, 2021 | Northern Colorado 17, Southern Utah 9 | Box score |
| Oct 23, 2021 | Alcorn State 44, Texas Southern 27 | Box score |
| Oct 23, 2021 | Stephen F. Austin 37, Utah Tech 20 | Box score |
| Oct 23, 2021 | Sacramento State 44, Northern Arizona 0 | Box score |
| Oct 23, 2021 | Central Washington 53, Western Oregon 21 | Box score |