| Oct 28, 2021 | Charleston (WV) 45, West Virginia Wesleyan 6 | Box score |
| Oct 29, 2021 | Princeton 34, Cornell 16 | Box score |
| Oct 30, 2021 | Robert Morris 38, Hampton 35 | Box score |
| Oct 30, 2021 | Yale 37, Columbia 30 | Box score |
| Oct 30, 2021 | Dartmouth 20, Harvard 17 | Box score |
| Oct 30, 2021 | Holy Cross 31, Lehigh 12 | Box score |
| Oct 30, 2021 | Saginaw Valley State 24, Davenport 3 | Box score |
| Oct 30, 2021 | West Alabama 31, North Greenville 14 | Box score |
| Oct 30, 2021 | Mercyhurst 38, Clarion 20 | Box score |
| Oct 30, 2021 | Slippery Rock 63, Gannon 21 | Box score |
| Oct 30, 2021 | Notre Dame College 45, Fairmont State 0 | Box score |
| Oct 30, 2021 | Findlay 49, Walsh 0 | Box score |
| Oct 30, 2021 | Wheeling 15, Concord 14 | Box score |
| Oct 30, 2021 | UNC Pembroke 27, West Liberty 17 | Box score |
| Oct 30, 2021 | Stonehill 19, Pace 8 | Box score |
| Oct 30, 2021 | Lafayette 24, Georgetown 23 | Box score |
| Oct 30, 2021 | Bowie State 31, Lincoln (PA) 7 | Box score |
| Oct 30, 2021 | Virginia Union 44, Elizabeth City State 14 | Box score |
| Oct 30, 2021 | Delaware 17, Utah Tech 10 | Box score |
| Oct 30, 2021 | Johnson C. Smith 34, St. Augustine’s 13 | Box score |
| Oct 30, 2021 | Charleston Southern 27, Campbell 14 | Box score |
| Oct 30, 2021 | Kennesaw State 34, Gardner-Webb 30 | Box score |
| Oct 30, 2021 | Monmouth 35, North Carolina A&T 16 | Box score |
| Oct 30, 2021 | Maine 45, Rhode Island 24 | Box score |
| Oct 30, 2021 | Richmond 35, New Hampshire 21upset | Box score |
| Oct 30, 2021 | Shaw 38, Winston-Salem State 14 | Box score |
| Oct 30, 2021 | William & Mary 31, Villanova 18upset | Box score |
| Oct 30, 2021 | Pennsylvania 45, Brown 17 | Box score |
| Oct 30, 2021 | Colgate 33, Bucknell 10 | Box score |
| Oct 30, 2021 | Dayton 38, Butler 31 | Box score |
| Oct 30, 2021 | Nicholls 42, Northwestern State 21 | Box score |
| Oct 30, 2021 | Truman State 49, Quincy 28 | Box score |
| Oct 30, 2021 | Ashland 28, Hillsdale 17 | Box score |
| Oct 30, 2021 | New Haven 16, Assumption 10 | Box score |
| Oct 30, 2021 | Ferris State 44, Northern Michigan 24 | Box score |
| Oct 30, 2021 | Northern State 33, Minnesota St Moorhead 27 | Box score |
| Oct 30, 2021 | Lane College 16, Central State 14 | Box score |
| Oct 30, 2021 | Central Connecticut 49, Merrimack 21upset | Box score |
| Oct 30, 2021 | West Virginia State 38, Glenville State 27 | Box score |
| Oct 30, 2021 | Upper Iowa 42, Wayne State (NE) 41upset | Box score |
| Oct 30, 2021 | Saint Anselm 21, American International 16 | Box score |
| Oct 30, 2021 | Catawba 31, Tusculum 28 | Box score |
| Oct 30, 2021 | Frostburg State 45, Alderson-Broaddus 7 | Box score |
| Oct 30, 2021 | Long Island University 28, Wagner 14 | Box score |
| Oct 30, 2021 | Bentley 24, Franklin Pierce 14 | Box score |
| Oct 30, 2021 | Stetson 56, Presbyterian 14 | Box score |
| Oct 30, 2021 | Newberry 48, Erskine 10 | Box score |
| Oct 30, 2021 | Shippensburg 24, East Stroudsburg 23 | Box score |
| Oct 30, 2021 | Chattanooga 13, Furman 3 | Box score |
| Oct 30, 2021 | VMI 46, Samford 45 | Box score |
| Oct 30, 2021 | Western Carolina 41, Wofford 21 | Box score |
| Oct 30, 2021 | Chowan 38, Virginia State 30 | Box score |
| Oct 30, 2021 | Central Arkansas 38, Jacksonville State 14 | Box score |
| Oct 30, 2021 | Eastern Kentucky 42, Lamar 10 | Box score |
| Oct 30, 2021 | Montana 20, Southern Utah 19 | Box score |
| Oct 30, 2021 | Fayetteville State 34, Livingstone 0 | Box score |
| Oct 30, 2021 | Towson 38, UAlbany 24 | Box score |
| Oct 30, 2021 | James Madison 45, Elon 21 | Box score |
| Oct 30, 2021 | Delaware State 30, Howard 23 | Box score |
| Oct 30, 2021 | Norfolk State 31, Morgan State 20 | Box score |
| Oct 30, 2021 | South Carolina State 27, North Carolina Central 24 | Box score |
| Oct 30, 2021 | South Dakota State 47, Youngstown State 16 | Box score |
| Oct 30, 2021 | Southeast Missouri State 38, Eastern Illinois 15 | Box score |
| Oct 30, 2021 | St. Thomas (MN) 27, Marist 7 | Box score |
| Oct 30, 2021 | Davidson 29, Morehead State 22 | Box score |
| Oct 30, 2021 | Mercer 34, The Citadel 7 | Box score |
| Oct 30, 2021 | Lindenwood 53, William Jewell 10 | Box score |
| Oct 30, 2021 | McKendree 45, Southwest Baptist 42 | Box score |
| Oct 30, 2021 | Missouri S&T 31, Indianapolis 28 | Box score |
| Oct 30, 2021 | Savannah State 24, Fort Valley State 6 | Box score |
| Oct 30, 2021 | Augustana (SD) 38, Winona State 20 | Box score |
| Oct 30, 2021 | Albany State 14, Morehouse 10 | Box score |
| Oct 30, 2021 | Benedict 24, Clark Atlanta 21 | Box score |
| Oct 30, 2021 | Shepherd 62, Bloomsburg 18 | Box score |
| Oct 30, 2021 | Edinboro 21, IU Pennsylvania 17upset | Box score |
| Oct 30, 2021 | Colorado School of Mines 34, Chadron State 7 | Box score |
| Oct 30, 2021 | CSU Pueblo 73, Fort Lewis 0 | Box score |
| Oct 30, 2021 | Pittsburg State 26, Central Oklahoma 20 | Box score |
| Oct 30, 2021 | Emporia State 15, Fort Hays 12 | Box score |
| Oct 30, 2021 | Sioux Falls 45, Minnesota State 35 | Box score |
| Oct 30, 2021 | Washburn 35, Northeastern State 0 | Box score |
| Oct 30, 2021 | Bemidji State 48, Southwest Minnesota State 14 | Box score |
| Oct 30, 2021 | Minnesota Duluth 34, Minot State 21 | Box score |
| Oct 30, 2021 | Kentucky State 42, Tuskegee 35 | Box score |
| Oct 30, 2021 | Barton 62, Bluefield State 7 | Box score |
| Oct 30, 2021 | Kutztown 30, Millersville 7 | Box score |
| Oct 30, 2021 | Weber State 40, Idaho State 17 | Box score |
| Oct 30, 2021 | Sacramento State 27, Northern Colorado 24 | Box score |
| Oct 30, 2021 | Southeastern Oklahoma State 34, Arkansas Monticello 14 | Box score |
| Oct 30, 2021 | Ouachita Baptist 43, East Central 28 | Box score |
| Oct 30, 2021 | Missouri State 32, North Dakota 28 | Box score |
| Oct 30, 2021 | Harding 73, Northwestern (OK) 14 | Box score |
| Oct 30, 2021 | Henderson State 34, Southern Nazarene 3 | Box score |
| Oct 30, 2021 | UT Martin 17, Austin Peay 16 | Box score |
| Oct 30, 2021 | Oklahoma Baptist 44, Southern Arkansas 40 | Box score |
| Oct 30, 2021 | Texas Southern 59, Arkansas–Pine Bluff 17 | Box score |
| Oct 30, 2021 | Grand Valley State 14, Michigan Tech 9 | Box score |
| Oct 30, 2021 | Delta State 14, Shorter 13 | Box score |
| Oct 30, 2021 | West Florida 63, Mississippi College 28 | Box score |
| Oct 30, 2021 | New Mexico Highlands 58, Adams State 28 | Box score |
| Oct 30, 2021 | University of Mary 42, Concordia St. Paul 17 | Box score |
| Oct 30, 2021 | South Dakota Mines 13, Black Hills State 10 | Box score |
| Oct 30, 2021 | Western Colorado 23, Colorado Mesa 9 | Box score |
| Oct 30, 2021 | Central Missouri 77, Lincoln (MO) 35 | Box score |
| Oct 30, 2021 | Missouri Western 45, Missouri Southern State 28 | Box score |
| Oct 30, 2021 | Lake Erie 38, Kentucky Wesleyan 28 | Box score |
| Oct 30, 2021 | Northwest Missouri State 66, Nebraska Kearney 13 | Box score |
| Oct 30, 2021 | Mars Hill 49, Carson Newman 23 | Box score |
| Oct 30, 2021 | Saint Francis 17, Duquesne 10upset | Box score |
| Oct 30, 2021 | North Dakota State 44, Indiana State 2 | Box score |
| Oct 30, 2021 | Alabama A&M 42, Alabama State 28 | Box score |
| Oct 30, 2021 | Northern Arizona 38, Idaho 31 | Box score |
| Oct 30, 2021 | Western Illinois 38, Illinois State 31 | Box score |
| Oct 30, 2021 | San Diego 21, Valparaiso 14 | Box score |
| Oct 30, 2021 | Incarnate Word 49, Houston Christian 21 | Box score |
| Oct 30, 2021 | Florida A&M 26, Grambling 3 | Box score |
| Oct 30, 2021 | Jackson State 28, Mississippi Valley State 19 | Box score |
| Oct 30, 2021 | Western Oregon 42, Simon Fraser 3 | Box score |
| Oct 30, 2021 | California (PA) 42, Seton Hill 14 | Box score |
| Oct 30, 2021 | West Chester 35, Lock Haven 13 | Box score |
| Oct 30, 2021 | Tiffin 34, Ohio Dominican 21 | Box score |
| Oct 30, 2021 | UVA Wise 28, Limestone 24 | Box score |
| Oct 30, 2021 | Portland State 42, Cal Poly 21 | Box score |
| Oct 30, 2021 | Northern Iowa 23, Southern Illinois 16 | Box score |
| Oct 30, 2021 | Stephen F. Austin 41, Abilene Christian 27 | Box score |
| Oct 30, 2021 | East Texas A&M 41, UT Permian Basin 0 | Box score |
| Oct 30, 2021 | Tennessee State 27, Murray State 21 | Box score |
| Oct 30, 2021 | Miles 16, Edward Waters 9 | Box score |
| Oct 30, 2021 | Wayne State (MI) 56, Northwood 21 | Box score |
| Oct 30, 2021 | Lenoir Rhyne 31, Wingate 6 | Box score |
| Oct 30, 2021 | Arkansas Tech 15, Southwestern Oklahoma State 14 | Box score |
| Oct 30, 2021 | Sam Houston 45, Tarleton State 27 | Box score |
| Oct 30, 2021 | SE Louisiana 23, McNeese 20 | Box score |
| Oct 30, 2021 | Southern 38, Alcorn State 35 | Box score |
| Oct 30, 2021 | Valdosta State 36, West Georgia 34 | Box score |
| Oct 30, 2021 | Angelo State 59, Eastern New Mexico 7 | Box score |
| Oct 30, 2021 | Midwestern State 52, Western New Mexico 10 | Box score |
| Oct 30, 2021 | West Texas 35, Texas A&M–Kingsville 23 | Box score |
| Oct 30, 2021 | Central Washington 92, Lincoln (CA) 0 | Box score |