| Sep 25, 2010 | 25Michigan State 45, Northern Colorado 7 | Box score |
| Sep 25, 2010 | New Hampshire 31, Lehigh 10 | Box score |
| Sep 25, 2010 | 11Wisconsin 70, Austin Peay 3 | Box score |
| Sep 25, 2010 | Central Connecticut 41, Bryant 24 | Box score |
| Sep 25, 2010 | Duquesne 28, UAlbany 17 | Box score |
| Sep 25, 2010 | Morehead State 45, Marist 39upset | Box score |
| Sep 25, 2010 | North Greenville 34, Presbyterian 17 | Box score |
| Sep 25, 2010 | Robert Morris 30, Wagner 9 | Box score |
| Sep 25, 2010 | Columbia 24, Towson 10 | Box score |
| Sep 25, 2010 | Yale 21, Cornell 7 | Box score |
| Sep 25, 2010 | Georgia State 24, Campbell 21 | Box score |
| Sep 25, 2010 | Jacksonville 42, Davidson 15 | Box score |
| Sep 25, 2010 | Assumption 30, Fordham 24 | Box score |
| Sep 25, 2010 | Old Dominion 35, Monmouth 21 | Box score |
| Sep 25, 2010 | Dartmouth 21, Sacred Heart 19 | Box score |
| Sep 25, 2010 | Virginia 48, VMI 7 | Box score |
| Sep 25, 2010 | Georgetown 17, Holy Cross 7 | Box score |
| Sep 25, 2010 | Furman 31, The Citadel 14 | Box score |
| Sep 25, 2010 | Albany State 28, Savannah State 14 | Box score |
| Sep 25, 2010 | Tuskegee 21, Texas Southern 14 | Box score |
| Sep 25, 2010 | Drake 21, Valparaiso 19 | Box score |
| Sep 25, 2010 | Jacksonville State 28, Eastern Illinois 23 | Box score |
| Sep 25, 2010 | App State 35, Samford 17 | Box score |
| Sep 25, 2010 | Montana State 30, Eastern Washington 7 | Box score |
| Sep 25, 2010 | Montana 28, Sacramento State 25 | Box score |
| Sep 25, 2010 | Morgan State 20, Howard 3 | Box score |
| Sep 25, 2010 | Syracuse 42, Colgate 7 | Box score |
| Sep 25, 2010 | Arkansas–Pine Bluff 35, Clark Atlanta 19 | Box score |
| Sep 25, 2010 | Bethune-Cookman 21, Norfolk State 7 | Box score |
| Sep 25, 2010 | Tennessee State 29, Florida A&M 18 | Box score |
| Sep 25, 2010 | Western Illinois 40, Indiana State 7 | Box score |
| Sep 25, 2010 | Youngstown State 31, Southern Illinois 28 | Box score |
| Sep 25, 2010 | North Dakota 49, Northwestern State 24 | Box score |
| Sep 25, 2010 | Alcorn State 41, Alabama State 21 | Box score |
| Sep 25, 2010 | Nicholls 44, Bacone College 28 | Box score |
| Sep 25, 2010 | Northern Arizona 32, Idaho State 7 | Box score |
| Sep 25, 2010 | Princeton 36, Lafayette 33 | Box score |
| Sep 25, 2010 | Brown 29, Harvard 14 | Box score |
| Sep 25, 2010 | James Madison 10, Liberty 3 | Box score |
| Sep 25, 2010 | Georgia Southern 38, Elon 21 | Box score |
| Sep 25, 2010 | Coastal Carolina 34, Delaware State 14 | Box score |
| Sep 25, 2010 | North Carolina Central 27, North Carolina A&T 16 | Box score |
| Sep 25, 2010 | Massachusetts 26, Stony Brook 21 | Box score |
| Sep 25, 2010 | Chattanooga 27, Western Carolina 21 | Box score |
| Sep 25, 2010 | Iowa State 27, Northern Iowa 0 | Box score |
| Sep 25, 2010 | Murray State 52, UT Martin 16 | Box score |
| Sep 25, 2010 | 6Nebraska 17, South Dakota State 3 | Box score |
| Sep 25, 2010 | Tulsa 41, Central Arkansas 14 | Box score |
| Sep 25, 2010 | Villanova 22, Pennsylvania 10 | Box score |
| Sep 25, 2010 | Texas State 42, Southern Utah 28 | Box score |
| Sep 25, 2010 | Alabama A&M 34, Southern 14 | Box score |
| Sep 25, 2010 | Dayton 45, Central State 13 | Box score |
| Sep 25, 2010 | Illinois State 44, Missouri State 41 | Box score |
| Sep 25, 2010 | Jackson State 43, Mississippi Valley State 7 | Box score |
| Sep 25, 2010 | UL Monroe 21, SE Louisiana 20 | Box score |
| Sep 25, 2010 | North Dakota State 38, South Dakota 16 | Box score |
| Sep 25, 2010 | Grambling 34, Prairie View A&M 17 | Box score |
| Sep 25, 2010 | Sam Houston 30, Gardner-Webb 14 | Box score |
| Sep 25, 2010 | Southeast Missouri State 23, Tennessee Tech 21 | Box score |
| Sep 25, 2010 | Stephen F. Austin 71, Lamar 3 | Box score |
| Sep 25, 2010 | Cal Poly 40, McNeese 14upset | Box score |
| Sep 25, 2010 | Weber State 20, UC Davis 9 | Box score |
| Sep 25, 2010 | San Diego 24, Butler 0 | Box score |
| Sep 25, 2010 | Hawai’i 66, Charleston Southern 7 | Box score |