| Sep 16, 2010 | Samford 38, Newberry 35 | Box score |
| Sep 16, 2010 | Tennessee Tech 43, Lane College 0 | Box score |
| Sep 18, 2010 | Yale 40, Georgetown 35 | Box score |
| Sep 18, 2010 | 20Michigan 42, Massachusetts 37 | Box score |
| Sep 18, 2010 | Robert Morris 30, Liberty 23 | Box score |
| Sep 18, 2010 | Saint Francis 41, Sacred Heart 0 | Box score |
| Sep 18, 2010 | Fordham 16, Columbia 9 | Box score |
| Sep 18, 2010 | Brown 33, Stony Brook 30 | Box score |
| Sep 18, 2010 | Lehigh 35, Princeton 22 | Box score |
| Sep 18, 2010 | Florida A&M 50, Howard 7 | Box score |
| Sep 18, 2010 | Richmond 27, Elon 21 | Box score |
| Sep 18, 2010 | Dartmouth 43, Bucknell 20 | Box score |
| Sep 18, 2010 | Jacksonville State 34, Georgia State 27 | Box score |
| Sep 18, 2010 | Texas Southern 32, Alabama A&M 9 | Box score |
| Sep 18, 2010 | Wagner 41, Cornell 7 | Box score |
| Sep 18, 2010 | Bryant 46, Merrimack 29 | Box score |
| Sep 18, 2010 | Charleston Southern 28, Mars Hill 14 | Box score |
| Sep 18, 2010 | South Carolina State 61, Benedict 20 | Box score |
| Sep 18, 2010 | Western Illinois 56, Sam Houston 14 | Box score |
| Sep 18, 2010 | Montana State 48, Drake 21 | Box score |
| Sep 18, 2010 | App State 44, North Carolina Central 16 | Box score |
| Sep 18, 2010 | Northern Colorado 35, Idaho State 21 | Box score |
| Sep 18, 2010 | Bethune-Cookman 42, Savannah State 7 | Box score |
| Sep 18, 2010 | North Dakota 55, Northeastern State 14 | Box score |
| Sep 18, 2010 | Alcorn State 27, Mississippi Valley State 9 | Box score |
| Sep 18, 2010 | Alabama State 18, Prairie View A&M 15upset | Box score |
| Sep 18, 2010 | Grambling 28, Jackson State 21 | Box score |
| Sep 18, 2010 | South Dakota 48, Northwestern (OK) 14 | Box score |
| Sep 18, 2010 | Stephen F. Austin 22, Northern Iowa 20 | Box score |
| Sep 18, 2010 | Delaware 30, Duquesne 6 | Box score |
| Sep 18, 2010 | Chattanooga 42, Eastern Kentucky 24 | Box score |
| Sep 18, 2010 | Georgia Southern 43, Coastal Carolina 26 | Box score |
| Sep 18, 2010 | Western Carolina 28, Gardner-Webb 14upset | Box score |
| Sep 18, 2010 | Hampton 35, North Carolina A&T 21 | Box score |
| Sep 18, 2010 | Norfolk State 51, Virginia State 28 | Box score |
| Sep 18, 2010 | Youngstown State 63, Central Connecticut 24 | Box score |
| Sep 18, 2010 | 5Oregon 69, Portland State 0 | Box score |
| Sep 18, 2010 | Southeast Missouri State 24, Southern Illinois 21upset | Box score |
| Sep 18, 2010 | Harvard 34, Holy Cross 6 | Box score |
| Sep 18, 2010 | Pennsylvania 19, Lafayette 14 | Box score |
| Sep 18, 2010 | William & Mary 21, Old Dominion 17 | Box score |
| Sep 18, 2010 | Texas State 21, Cal Poly 12 | Box score |
| Sep 18, 2010 | Central Arkansas 21, Murray State 20 | Box score |
| Sep 18, 2010 | North Dakota State 35, Morgan State 9 | Box score |
| Sep 18, 2010 | Illinois State 24, South Dakota State 14 | Box score |
| Sep 18, 2010 | 13South Carolina 38, Furman 19 | Box score |
| Sep 18, 2010 | UT Martin 20, Eastern Illinois 10 | Box score |
| Sep 18, 2010 | Austin Peay 26, Tennessee State 23upset | Box score |
| Sep 18, 2010 | The Citadel 26, Presbyterian 14 | Box score |
| Sep 18, 2010 | Wofford 48, Union College 10 | Box score |
| Sep 18, 2010 | Eastern Washington 36, Montana 27 | Box score |
| Sep 18, 2010 | Syracuse 38, Maine 14 | Box score |
| Sep 18, 2010 | San José State 16, Southern Utah 11 | Box score |
| Sep 18, 2010 | Sacramento State 24, Weber State 17 | Box score |
| Sep 18, 2010 | UC Davis 38, San Diego 24 | Box score |