| Sep 11, 2010 | UConn 62, Texas Southern 3 | Box score |
| Sep 11, 2010 | Northwestern 37, Illinois State 3 | Box score |
| Sep 11, 2010 | South Dakota 41, Minnesota 38upset | Box score |
| Sep 11, 2010 | Gardner-Webb 38, Akron 37 | Box score |
| Sep 11, 2010 | Central Connecticut 45, Bentley 14 | Box score |
| Sep 11, 2010 | Cincinnati 40, Indiana State 7 | Box score |
| Sep 11, 2010 | Duquesne 35, Dayton 31upset | Box score |
| Sep 11, 2010 | Purdue 31, Western Illinois 21 | Box score |
| Sep 11, 2010 | Robert Morris 35, Sacred Heart 31 | Box score |
| Sep 11, 2010 | Villanova 35, Lehigh 0 | Box score |
| Sep 11, 2010 | Hampton 31, Howard 21 | Box score |
| Sep 11, 2010 | Delaware 26, South Dakota State 3 | Box score |
| Sep 11, 2010 | Pittsburgh 38, New Hampshire 16 | Box score |
| Sep 11, 2010 | Old Dominion 44, Campbell 13 | Box score |
| Sep 11, 2010 | Lambuth 23, Georgia State 14upset | Box score |
| Sep 11, 2010 | Maine 31, Monmouth 23 | Box score |
| Sep 11, 2010 | Morehead State 31, Saint Francis 21 | Box score |
| Sep 11, 2010 | Bryant 44, Saint Anselm 21 | Box score |
| Sep 11, 2010 | James Madison 21, 13Virginia Tech 16upset | Box score |
| Sep 11, 2010 | Wofford 34, Charleston Southern 23 | Box score |
| Sep 11, 2010 | Franklin 42, Valparaiso 7 | Box score |
| Sep 11, 2010 | Furman 45, Colgate 15 | Box score |
| Sep 11, 2010 | Central Arkansas 37, Eastern Illinois 7 | Box score |
| Sep 11, 2010 | Louisville 23, Eastern Kentucky 13 | Box score |
| Sep 11, 2010 | Clemson 58, Presbyterian 21 | Box score |
| Sep 11, 2010 | App State 45, Jacksonville 14 | Box score |
| Sep 11, 2010 | Navy 13, Georgia Southern 7 | Box score |
| Sep 11, 2010 | Norfolk State 23, North Carolina A&T 14 | Box score |
| Sep 11, 2010 | Fort Valley State 41, Savannah State 10 | Box score |
| Sep 11, 2010 | Massachusetts 31, Holy Cross 7 | Box score |
| Sep 11, 2010 | Maryland 62, Morgan State 3 | Box score |
| Sep 11, 2010 | Georgetown 28, Lafayette 24upset | Box score |
| Sep 11, 2010 | Florida A&M 17, Delaware State 14 | Box score |
| Sep 11, 2010 | Fordham 27, Rhode Island 25 | Box score |
| Sep 11, 2010 | Marist 14, Bucknell 3 | Box score |
| Sep 11, 2010 | Winston-Salem State 34, North Carolina Central 27upset | Box score |
| Sep 11, 2010 | Samford 19, Northwestern State 7 | Box score |
| Sep 11, 2010 | South Carolina State 44, Mississippi Valley State 0 | Box score |
| Sep 11, 2010 | Stony Brook 31, American International 14 | Box score |
| Sep 11, 2010 | Tusculum 54, Western Carolina 30 | Box score |
| Sep 11, 2010 | Youngstown State 31, Butler 7 | Box score |
| Sep 11, 2010 | Jacksonville State 21, Chattanooga 17 | Box score |
| Sep 11, 2010 | Southeast Missouri State 30, Murray State 17 | Box score |
| Sep 11, 2010 | Towson 47, Coastal Carolina 45 | Box score |
| Sep 11, 2010 | Missouri 50, McNeese 6 | Box score |
| Sep 11, 2010 | Washington State 23, Montana State 22 | Box score |
| Sep 11, 2010 | Texas State 31, Southern Arkansas 17 | Box score |
| Sep 11, 2010 | Alabama A&M 45, Central State 0 | Box score |
| Sep 11, 2010 | Assumption 24, Wagner 9 | Box score |
| Sep 11, 2010 | Liberty 27, Ball State 23 | Box score |
| Sep 11, 2010 | Elon 55, Shaw 26 | Box score |
| Sep 11, 2010 | Lamar 21, Webber International 14 | Box score |
| Sep 11, 2010 | Lenoir Rhyne 41, Davidson 13 | Box score |
| Sep 11, 2010 | Middle Tennessee 56, Austin Peay 33 | Box score |
| Sep 11, 2010 | Northern Illinois 23, North Dakota 17 | Box score |
| Sep 11, 2010 | SE Louisiana 24, UT Martin 10 | Box score |
| Sep 11, 2010 | Southern Miss 34, Prairie View A&M 7 | Box score |
| Sep 11, 2010 | Arkansas Monticello 31, Southern 7upset | Box score |
| Sep 11, 2010 | Stephen F. Austin 59, UAlbany 14 | Box score |
| Sep 11, 2010 | 4TCU 62, Tennessee Tech 7 | Box score |
| Sep 11, 2010 | Jackson State 33, Tennessee State 26 | Box score |
| Sep 11, 2010 | Western Michigan 49, Nicholls 14 | Box score |
| Sep 11, 2010 | William & Mary 45, VMI 0 | Box score |
| Sep 11, 2010 | Kansas State 48, Missouri State 24 | Box score |
| Sep 11, 2010 | Illinois 35, Southern Illinois 3 | Box score |
| Sep 11, 2010 | Northern Iowa 16, North Dakota State 9 | Box score |
| Sep 11, 2010 | Southern Utah 32, San Diego 3 | Box score |
| Sep 11, 2010 | Utah State 38, Idaho State 17 | Box score |
| Sep 11, 2010 | Alabama State 38, Arkansas–Pine Bluff 31 | Box score |
| Sep 11, 2010 | Drake 28, Missouri S&T 14 | Box score |
| Sep 11, 2010 | Weber State 50, Northern Colorado 47 | Box score |
| Sep 11, 2010 | Eastern Washington 35, Central Washington 32 | Box score |
| Sep 11, 2010 | Cal Poly 35, Montana 33upset | Box score |
| Sep 11, 2010 | Sacramento State 31, Western Oregon 17 | Box score |
| Sep 11, 2010 | Portland State 41, UC Davis 33upset | Box score |
| Sep 11, 2010 | Arizona State 41, Northern Arizona 20 | Box score |
| Sep 11, 2010 | Arizona 52, The Citadel 6 | Box score |