| Sep 2, 2010 | Wake Forest 53, Presbyterian 13 | Box score |
| Sep 2, 2010 | Delaware 31, West Chester 0 | Box score |
| Sep 2, 2010 | UAlbany 3, Maine 0 | Box score |
| Sep 2, 2010 | Ball State 27, Southeast Missouri State 10 | Box score |
| Sep 2, 2010 | Buffalo 31, Rhode Island 0 | Box score |
| Sep 2, 2010 | Central Michigan 33, Hampton 0 | Box score |
| Sep 2, 2010 | Kent State 41, Murray State 10 | Box score |
| Sep 2, 2010 | North Carolina Central 59, Johnson C. Smith 0 | Box score |
| Sep 2, 2010 | Western Illinois 45, Valparaiso 0 | Box score |
| Sep 2, 2010 | Indiana 51, Towson 17 | Box score |
| Sep 2, 2010 | Rutgers 31, Norfolk State 0 | Box score |
| Sep 2, 2010 | Georgia State 41, Shorter 7 | Box score |
| Sep 2, 2010 | Illinois State 55, Central Missouri 54 | Box score |
| Sep 2, 2010 | 13Miami 45, Florida A&M 0 | Box score |
| Sep 2, 2010 | Southern Illinois 70, Quincy 7 | Box score |
| Sep 2, 2010 | Central Arkansas 47, Elizabeth City State 20 | Box score |
| Sep 2, 2010 | Tulane 27, SE Louisiana 21 | Box score |
| Sep 2, 2010 | Idaho 45, North Dakota 0 | Box score |
| Sep 2, 2010 | Nevada 49, Eastern Washington 24 | Box score |
| Sep 2, 2010 | Northern Arizona 48, Western New Mexico 0 | Box score |
| Sep 3, 2010 | Missouri State 31, Eastern Kentucky 9 | Box score |
| Sep 3, 2010 | Temple 31, Villanova 24 | Box score |
| Sep 3, 2010 | Sacred Heart 28, Marist 25upset | Box score |
| Sep 4, 2010 | 20Florida State 59, Samford 6 | Box score |
| Sep 4, 2010 | New Hampshire 33, Central Connecticut 3 | Box score |
| Sep 4, 2010 | 19Penn State 44, Youngstown State 14 | Box score |
| Sep 4, 2010 | Liberty 52, Saint Francis 7 | Box score |
| Sep 4, 2010 | 9Iowa 37, Eastern Illinois 7 | Box score |
| Sep 4, 2010 | 16Georgia Tech 41, South Carolina State 10 | Box score |
| Sep 4, 2010 | Boston College 38, Weber State 20 | Box score |
| Sep 4, 2010 | Holy Cross 38, Howard 7 | Box score |
| Sep 4, 2010 | Dayton 28, Robert Morris 14 | Box score |
| Sep 4, 2010 | The Citadel 56, Chowan 14 | Box score |
| Sep 4, 2010 | Butler 29, Albion 13 | Box score |
| Sep 4, 2010 | Charleston Southern 41, North Greenville 31 | Box score |
| Sep 4, 2010 | VMI 48, Lock Haven 6 | Box score |
| Sep 4, 2010 | Air Force 65, Northwestern State 21 | Box score |
| Sep 4, 2010 | Montana State 59, Fort Lewis 10 | Box score |
| Sep 4, 2010 | Montana 73, Western Colorado 2 | Box score |
| Sep 4, 2010 | App State 42, Chattanooga 41 | Box score |
| Sep 4, 2010 | Bryant 44, Fordham 30 | Box score |
| Sep 4, 2010 | Massachusetts 27, William & Mary 23upset | Box score |
| Sep 4, 2010 | Jacksonville State 49, Ole Miss 48upset | Box score |
| Sep 4, 2010 | 25West Virginia 31, Coastal Carolina 0 | Box score |
| Sep 4, 2010 | Northern Colorado 54, Adams State 0 | Box score |
| Sep 4, 2010 | California 52, UC Davis 3 | Box score |
| Sep 4, 2010 | Bethune-Cookman 70, Edward Waters 10 | Box score |
| Sep 4, 2010 | Alcorn State 50, Langston 27 | Box score |
| Sep 4, 2010 | Jackson State 32, Delta State 17 | Box score |
| Sep 4, 2010 | Idaho State 32, Montana Western 3 | Box score |
| Sep 4, 2010 | NC State 48, Western Carolina 7 | Box score |
| Sep 4, 2010 | James Madison 48, Morehead State 7 | Box score |
| Sep 4, 2010 | Virginia 34, Richmond 13 | Box score |
| Sep 4, 2010 | Georgia Southern 48, Savannah State 3 | Box score |
| Sep 4, 2010 | Jacksonville 35, Old Dominion 25 | Box score |
| Sep 4, 2010 | UCF 38, South Dakota 7 | Box score |
| Sep 4, 2010 | Colgate 30, Monmouth 29 | Box score |
| Sep 4, 2010 | Georgetown 20, Davidson 10upset | Box score |
| Sep 4, 2010 | Duquesne 17, Bucknell 13 | Box score |
| Sep 4, 2010 | Gardner-Webb 28, Brevard 14 | Box score |
| Sep 4, 2010 | Morgan State 14, Bowie State 7 | Box score |
| Sep 4, 2010 | Winston-Salem State 21, North Carolina A&T 14 | Box score |
| Sep 4, 2010 | Tennessee 50, UT Martin 0 | Box score |
| Sep 4, 2010 | Campbell 20, UVA Wise 16 | Box score |
| Sep 4, 2010 | Stanford 52, Sacramento State 17 | Box score |
| Sep 4, 2010 | 17Arkansas 44, Tennessee Tech 3 | Box score |
| Sep 4, 2010 | Duke 41, Elon 27 | Box score |
| Sep 4, 2010 | Ohio 33, Wofford 10 | Box score |
| Sep 4, 2010 | Baylor 34, Sam Houston 3 | Box score |
| Sep 4, 2010 | Texas A&M 48, Stephen F. Austin 7 | Box score |
| Sep 4, 2010 | Indiana State 57, St. Joseph’s (IN) 7 | Box score |
| Sep 4, 2010 | Lehigh 28, Drake 14 | Box score |
| Sep 4, 2010 | North Dakota State 6, Kansas 3upset | Box score |
| Sep 4, 2010 | Tennessee State 27, Alabama A&M 14 | Box score |
| Sep 4, 2010 | Louisiana Tech 20, Grambling 6 | Box score |
| Sep 4, 2010 | South Florida 59, Stony Brook 14 | Box score |
| Sep 4, 2010 | San Diego State 47, Nicholls 0 | Box score |
| Sep 4, 2010 | Houston 68, Texas State 28 | Box score |
| Sep 4, 2010 | Alabama State 34, Mississippi Valley State 6 | Box score |
| Sep 4, 2010 | McNeese 30, Lamar 27 | Box score |
| Sep 4, 2010 | Azusa Pacific 42, San Diego 14upset | Box score |
| Sep 4, 2010 | Wyoming 28, Southern Utah 20 | Box score |
| Sep 4, 2010 | Cal Poly 23, Humboldt State 17 | Box score |
| Sep 4, 2010 | UTEP 31, Arkansas–Pine Bluff 10 | Box score |
| Sep 4, 2010 | Arizona State 54, Portland State 9 | Box score |
| Sep 5, 2010 | Southern 37, Delaware State 27 | Box score |
| Sep 5, 2010 | Prairie View A&M 16, Texas Southern 14 | Box score |