| Sep 25, 1953 | Miami 27, Florida State 0 | Box score |
| Sep 25, 1953 | San José State 28, BYU 25 | Box score |
| Sep 25, 1953 | 4UCLA 19, Kansas 7 | Box score |
| Sep 26, 1953 | Army 41, Furman 0 | Box score |
| Sep 26, 1953 | 14California 26, Oregon State 0 | Box score |
| Sep 26, 1953 | Boston College 14, Clemson 14 | Box score |
| Sep 26, 1953 | Colorado 20, Arizona 14 | Box score |
| Sep 26, 1953 | Colorado State 14, Kansas State 13 | Box score |
| Sep 26, 1953 | Cornell 27, Colgate 7 | Box score |
| Sep 26, 1953 | Denver 33, Drake 14 | Box score |
| Sep 26, 1953 | 10Duke 19, Wake Forest 0 | Box score |
| Sep 26, 1953 | George Washington 14, VMI 13 | Box score |
| Sep 26, 1953 | Georgia 16, Tulane 14 | Box score |
| Sep 26, 1953 | 15Florida 0, 3Georgia Tech 0 | Box score |
| Sep 26, 1953 | Holy Cross 28, Dartmouth 6 | Box score |
| Sep 26, 1953 | Texas A&M 14, Houston 14 | Box score |
| Sep 26, 1953 | LSU 7, 5Alabama 7 | Box score |
| Sep 26, 1953 | Marquette 31, Cincinnati 7 | Box score |
| Sep 26, 1953 | 9Maryland 52, Washington and Lee 0 | Box score |
| Sep 26, 1953 | Michigan 50, Washington 0 | Box score |
| Sep 26, 1953 | 2Michigan State 21, Iowa 7 | Box score |
| Sep 26, 1953 | Ole Miss 22, Kentucky 6 | Box score |
| Sep 26, 1953 | Mississippi State 26, 17Tennessee 0upset | Box score |
| Sep 26, 1953 | Missouri 14, Purdue 7 | Box score |
| Sep 26, 1953 | Illinois 21, Nebraska 21 | Box score |
| Sep 26, 1953 | North Carolina 29, NC State 7 | Box score |
| Sep 26, 1953 | Northwestern 35, Iowa State 0 | Box score |
| Sep 26, 1953 | 1Notre Dame 28, 6Oklahoma 21 | Box score |
| Sep 26, 1953 | 7Ohio State 36, Indiana 12 | Box score |
| Sep 26, 1953 | Oklahoma State 7, Arkansas 6 | Box score |
| Sep 26, 1953 | Pennsylvania 13, Vanderbilt 7 | Box score |
| Sep 26, 1953 | Richmond 16, Davidson 0 | Box score |
| Sep 26, 1953 | South Carolina 25, The Citadel 0 | Box score |
| Sep 26, 1953 | 8USC 17, Minnesota 7 | Box score |
| Sep 26, 1953 | Stanford 7, Oregon 0 | Box score |
| Sep 26, 1953 | Syracuse 42, Temple 0 | Box score |
| Sep 26, 1953 | 11Texas 41, Villanova 12 | Box score |
| Sep 26, 1953 | Texas Tech 27, UTEP 6 | Box score |
| Sep 26, 1953 | Utah 21, Idaho 0 | Box score |
| Sep 26, 1953 | Utah State 6, New Mexico 0 | Box score |
| Sep 26, 1953 | Virginia Tech 20, Virginia 6upset | Box score |
| Sep 26, 1953 | Washington State 26, Pacific 20 | Box score |
| Sep 26, 1953 | 16West Virginia 17, 17Pittsburgh 7 | Box score |
| Sep 26, 1953 | Wichita State 19, Tulsa 10upset | Box score |
| Sep 26, 1953 | 13Navy 6, William & Mary 6 | Box score |
| Sep 26, 1953 | Wisconsin 20, Penn State 0 | Box score |
| Sep 26, 1953 | Wyoming 27, Montana 7 | Box score |