| Oct 19, 1951 | Boston University 27, 16Pacific 12upset | Box score |
| Oct 19, 1951 | Detroit Mercy 19, Boston College 13 | Box score |
| Oct 19, 1951 | Furman 35, The Citadel 14 | Box score |
| Oct 19, 1951 | Miami 32, Washington and Lee 12 | Box score |
| Oct 19, 1951 | Wake Forest 27, George Washington 13 | Box score |
| Oct 20, 1951 | Arkansas 16, 4Texas 14upset | Box score |
| Oct 20, 1951 | 10Baylor 40, Texas Tech 20 | Box score |
| Oct 20, 1951 | Bradley 34, New Mexico State 6 | Box score |
| Oct 20, 1951 | Wyoming 20, BYU 20 | Box score |
| Oct 20, 1951 | Colgate 32, Brown 14 | Box score |
| Oct 20, 1951 | Colorado 20, Kansas State 7 | Box score |
| Oct 20, 1951 | 14Cornell 27, Yale 0 | Box score |
| Oct 20, 1951 | Dartmouth 14, Syracuse 0 | Box score |
| Oct 20, 1951 | Duke 55, Virginia Tech 6 | Box score |
| Oct 20, 1951 | Florida 33, Vanderbilt 13 | Box score |
| Oct 20, 1951 | 5Georgia Tech 27, Auburn 7 | Box score |
| Oct 20, 1951 | Harvard 22, Army 21upset | Box score |
| Oct 20, 1951 | Holy Cross 53, New York University 6 | Box score |
| Oct 20, 1951 | Houston 35, Hardin Simmons 27 | Box score |
| Oct 20, 1951 | Idaho 40, San José State 7 | Box score |
| Oct 20, 1951 | 8Illinois 27, 20Washington 20 | Box score |
| Oct 20, 1951 | Indiana 32, 17Ohio State 10upset | Box score |
| Oct 20, 1951 | Iowa State 21, Missouri 14 | Box score |
| Oct 20, 1951 | Kentucky 35, 12Villanova 13upset | Box score |
| Oct 20, 1951 | LSU 7, Georgia 0 | Box score |
| Oct 20, 1951 | 7Maryland 14, North Carolina 7 | Box score |
| Oct 20, 1951 | Michigan 21, Iowa 0 | Box score |
| Oct 20, 1951 | 3Michigan State 32, Penn State 21 | Box score |
| Oct 20, 1951 | Minnesota 39, Nebraska 20 | Box score |
| Oct 20, 1951 | Ole Miss 25, Tulane 6 | Box score |
| Oct 20, 1951 | 18Northwestern 16, Navy 7 | Box score |
| Oct 20, 1951 | Notre Dame 33, Pittsburgh 0 | Box score |
| Oct 20, 1951 | 19Oklahoma 33, Kansas 21 | Box score |
| Oct 20, 1951 | Oklahoma State 27, Drake 14 | Box score |
| Oct 20, 1951 | Pennsylvania 28, Columbia 13 | Box score |
| Oct 20, 1951 | Rice 28, 15SMU 7upset | Box score |
| Oct 20, 1951 | Richmond 25, Davidson 6 | Box score |
| Oct 20, 1951 | San Francisco 32, Fordham 26 | Box score |
| Oct 20, 1951 | 11USC 21, 1California 14upset | Box score |
| Oct 20, 1951 | 13Stanford 21, Santa Clara 14 | Box score |
| Oct 20, 1951 | 2Tennessee 27, Alabama 13 | Box score |
| Oct 20, 1951 | TCU 20, 6Texas A&M 14upset | Box score |
| Oct 20, 1951 | UTEP 32, New Mexico 7 | Box score |
| Oct 20, 1951 | Tulsa 27, Marquette 21 | Box score |
| Oct 20, 1951 | UCLA 41, Oregon 0 | Box score |
| Oct 20, 1951 | Utah 17, Denver 14 | Box score |
| Oct 20, 1951 | Colorado State 20, Utah State 20 | Box score |
| Oct 20, 1951 | Virginia 34, VMI 14 | Box score |
| Oct 20, 1951 | Washington State 26, Oregon State 13 | Box score |
| Oct 20, 1951 | William & Mary 35, NC State 28 | Box score |
| Oct 20, 1951 | Wisconsin 31, Purdue 7 | Box score |