| Oct 5, 1951 | Boston University 39, Louisville 7 | Box score |
| Oct 5, 1951 | Miami 35, Florida State 13 | Box score |
| Oct 5, 1951 | Ole Miss 34, Boston College 7 | Box score |
| Oct 5, 1951 | 5Notre Dame 40, Detroit Mercy 6 | Box score |
| Oct 5, 1951 | Washington State 27, Oklahoma State 13 | Box score |
| Oct 6, 1951 | Arizona 28, West Texas 13 | Box score |
| Oct 6, 1951 | 19Baylor 27, Tulane 14 | Box score |
| Oct 6, 1951 | Brown 14, Yale 13upset | Box score |
| Oct 6, 1951 | 2California 55, Minnesota 14 | Box score |
| Oct 6, 1951 | The Citadel 34, Davidson 14 | Box score |
| Oct 6, 1951 | 18Clemson 6, NC State 0 | Box score |
| Oct 6, 1951 | Colorado 35, 20Kansas 27upset | Box score |
| Oct 6, 1951 | Columbia 35, Harvard 0 | Box score |
| Oct 6, 1951 | Cornell 41, Colgate 18 | Box score |
| Oct 6, 1951 | Denver 55, Montana 0 | Box score |
| Oct 6, 1951 | Florida 40, Loyola Marymount 7 | Box score |
| Oct 6, 1951 | 11Georgia Tech 13, 17Kentucky 7 | Box score |
| Oct 6, 1951 | Holy Cross 54, Fordham 20 | Box score |
| Oct 6, 1951 | Houston 6, Texas Tech 0 | Box score |
| Oct 6, 1951 | 8Illinois 14, Wisconsin 10 | Box score |
| Oct 6, 1951 | Indiana 13, Pittsburgh 6 | Box score |
| Oct 6, 1951 | Marquette 6, Iowa State 6 | Box score |
| Oct 6, 1951 | LSU 7, Rice 6 | Box score |
| Oct 6, 1951 | 9Maryland 33, George Washington 6 | Box score |
| Oct 6, 1951 | 1Michigan State 24, 7Ohio State 20 | Box score |
| Oct 6, 1951 | Mississippi State 6, 13Georgia 0upset | Box score |
| Oct 6, 1951 | Kansas State 6, Nebraska 6 | Box score |
| Oct 6, 1951 | New Mexico 20, New Mexico State 0 | Box score |
| Oct 6, 1951 | Northwestern 20, Army 14 | Box score |
| Oct 6, 1951 | 15Oregon State 34, Idaho 6 | Box score |
| Oct 6, 1951 | Pacific 34, Oregon 6 | Box score |
| Oct 6, 1951 | Pennsylvania 39, Dartmouth 14 | Box score |
| Oct 6, 1951 | 14Princeton 24, Navy 20 | Box score |
| Oct 6, 1951 | Purdue 34, Iowa 30 | Box score |
| Oct 6, 1951 | South Carolina 21, Furman 6 | Box score |
| Oct 6, 1951 | USC 20, 12Washington 13upset | Box score |
| Oct 6, 1951 | SMU 34, Missouri 0 | Box score |
| Oct 6, 1951 | Stanford 23, Michigan 13 | Box score |
| Oct 6, 1951 | Temple 14, Rutgers 7 | Box score |
| Oct 6, 1951 | 3Tennessee 26, 16Duke 0 | Box score |
| Oct 6, 1951 | 6Texas 45, North Carolina 20 | Box score |
| Oct 6, 1951 | 10Texas A&M 14, 4Oklahoma 7upset | Box score |
| Oct 6, 1951 | TCU 17, Arkansas 7 | Box score |
| Oct 6, 1951 | UCLA 44, Santa Clara 17 | Box score |
| Oct 6, 1951 | Utah 7, BYU 6 | Box score |
| Oct 6, 1951 | Vanderbilt 22, Alabama 20 | Box score |
| Oct 6, 1951 | Villanova 20, Penn State 14 | Box score |
| Oct 6, 1951 | Virginia 33, Virginia Tech 0 | Box score |
| Oct 6, 1951 | VMI 20, William & Mary 7 | Box score |
| Oct 6, 1951 | Wake Forest 56, Richmond 6 | Box score |
| Oct 6, 1951 | Washington and Lee 34, West Virginia 0 | Box score |
| Oct 6, 1951 | Wichita State 15, Bradley 6 | Box score |
| Oct 6, 1951 | Wyoming 37, Utah State 0 | Box score |