| Sep 28, 1951 | Houston 33, Detroit Mercy 7upset | Box score |
| Sep 28, 1951 | Utah State 21, Wichita State 7 | Box score |
| Sep 28, 1951 | West Virginia 18, Furman 7 | Box score |
| Sep 29, 1951 | Arkansas 30, Arizona State 13 | Box score |
| Sep 29, 1951 | Auburn 24, Vanderbilt 14upset | Box score |
| Sep 29, 1951 | 5California 35, 19Pennsylvania 0 | Box score |
| Sep 29, 1951 | Cincinnati 47, Tulsa 35 | Box score |
| Sep 29, 1951 | Clemson 20, Rice 14 | Box score |
| Sep 29, 1951 | 20Cornell 21, Syracuse 14 | Box score |
| Sep 29, 1951 | Davidson 32, Virginia Tech 20 | Box score |
| Sep 29, 1951 | Drake 20, Bradley 14 | Box score |
| Sep 29, 1951 | Duke 19, Pittsburgh 14 | Box score |
| Sep 29, 1951 | Fordham 14, Dartmouth 6 | Box score |
| Sep 29, 1951 | Georgia 28, North Carolina 16 | Box score |
| Sep 29, 1951 | Georgia Tech 27, Florida 0 | Box score |
| Sep 29, 1951 | Holy Cross 33, Harvard 6 | Box score |
| Sep 29, 1951 | 10Illinois 27, UCLA 13 | Box score |
| Sep 29, 1951 | Iowa 16, Kansas State 0 | Box score |
| Sep 29, 1951 | Kansas 53, Iowa State 33 | Box score |
| Sep 29, 1951 | LSU 13, 9Alabama 7upset | Box score |
| Sep 29, 1951 | 16Maryland 54, Washington and Lee 14 | Box score |
| Sep 29, 1951 | 2Michigan State 25, 17Michigan 0 | Box score |
| Sep 29, 1951 | Ole Miss 21, 6Kentucky 17upset | Box score |
| Sep 29, 1951 | Missouri 27, Oklahoma State 26 | Box score |
| Sep 29, 1951 | Montana 25, New Mexico 7 | Box score |
| Sep 29, 1951 | Yale 7, Navy 7 | Box score |
| Sep 29, 1951 | Northwestern 35, Colorado 14 | Box score |
| Sep 29, 1951 | 14Notre Dame 48, Indiana 6 | Box score |
| Sep 29, 1951 | 3Ohio State 7, SMU 0 | Box score |
| Sep 29, 1951 | 4Oklahoma 49, William & Mary 7 | Box score |
| Sep 29, 1951 | Oregon 39, Arizona 21 | Box score |
| Sep 29, 1951 | Oregon State 61, Utah 28 | Box score |
| Sep 29, 1951 | Pacific 41, Loyola Marymount 28 | Box score |
| Sep 29, 1951 | Penn State 40, Boston University 34 | Box score |
| Sep 29, 1951 | 18Princeton 54, New York University 20 | Box score |
| Sep 29, 1951 | San Francisco 28, Idaho 7 | Box score |
| Sep 29, 1951 | South Carolina 26, The Citadel 7 | Box score |
| Sep 29, 1951 | Stanford 26, San José State 13 | Box score |
| Sep 29, 1951 | Temple 20, Brown 14 | Box score |
| Sep 29, 1951 | 1Tennessee 14, Mississippi State 0 | Box score |
| Sep 29, 1951 | 11Texas 14, Purdue 0 | Box score |
| Sep 29, 1951 | 6Texas A&M 20, Texas Tech 7 | Box score |
| Sep 29, 1951 | TCU 28, 12Nebraska 7upset | Box score |
| Sep 29, 1951 | UTEP 41, New Mexico State 7 | Box score |
| Sep 29, 1951 | Tulane 21, Miami 7 | Box score |
| Sep 29, 1951 | Villanova 21, Army 7upset | Box score |
| Sep 29, 1951 | Virginia 20, George Washington 0 | Box score |
| Sep 29, 1951 | VMI 34, Richmond 0 | Box score |
| Sep 29, 1951 | Wake Forest 21, NC State 6 | Box score |
| Sep 29, 1951 | 8Washington 25, Minnesota 20 | Box score |
| Sep 29, 1951 | Washington State 34, Santa Clara 20 | Box score |
| Sep 29, 1951 | 15Wisconsin 22, Marquette 6 | Box score |
| Sep 29, 1951 | Wyoming 20, Denver 14 | Box score |