| Oct 13, 1950 | Alabama 34, Furman 6 | Box score |
| Oct 13, 1950 | Fordham 26, Boston College 6 | Box score |
| Oct 13, 1950 | George Washington 42, Virginia Tech 7 | Box score |
| Oct 13, 1950 | Illinois 14, UCLA 6 | Box score |
| Oct 13, 1950 | Loyola Marymount 14, San José State 7 | Box score |
| Oct 13, 1950 | Marquette 27, Detroit Mercy 13 | Box score |
| Oct 14, 1950 | Arkansas 27, Baylor 6 | Box score |
| Oct 14, 1950 | 1Army 27, 18Michigan 6 | Box score |
| Oct 14, 1950 | 7California 13, USC 7 | Box score |
| Oct 14, 1950 | The Citadel 19, Davidson 12 | Box score |
| Oct 14, 1950 | Colgate 35, Holy Cross 28 | Box score |
| Oct 14, 1950 | Colorado 28, Nebraska 19 | Box score |
| Oct 14, 1950 | Colorado State 27, BYU 14 | Box score |
| Oct 14, 1950 | 17Cornell 28, Harvard 7 | Box score |
| Oct 14, 1950 | Duke 7, NC State 0 | Box score |
| Oct 14, 1950 | Florida 27, Auburn 7 | Box score |
| Oct 14, 1950 | Georgia 27, Mississippi State 0 | Box score |
| Oct 14, 1950 | Georgia Tech 13, LSU 0 | Box score |
| Oct 14, 1950 | Hardin Simmons 41, Arizona State 14 | Box score |
| Oct 14, 1950 | Houston 27, Louisville 7 | Box score |
| Oct 14, 1950 | Idaho 14, Oregon 0 | Box score |
| Oct 14, 1950 | Kansas 33, Iowa State 21 | Box score |
| Oct 14, 1950 | 5Kentucky 41, Cincinnati 7 | Box score |
| Oct 14, 1950 | 8Maryland 25, Georgetown 14 | Box score |
| Oct 14, 1950 | Miami 20, 9Purdue 14upset | Box score |
| Oct 14, 1950 | 20Michigan State 33, William & Mary 14 | Box score |
| Oct 14, 1950 | Missouri 28, Kansas State 7 | Box score |
| Oct 14, 1950 | Northwestern 13, Minnesota 6 | Box score |
| Oct 14, 1950 | 10Notre Dame 13, Tulane 9 | Box score |
| Oct 14, 1950 | 12Ohio State 26, Indiana 14 | Box score |
| Oct 14, 1950 | 3Oklahoma 14, 4Texas 13 | Box score |
| Oct 14, 1950 | Pacific 43, Nevada 7 | Box score |
| Oct 14, 1950 | Pennsylvania 42, Dartmouth 26 | Box score |
| Oct 14, 1950 | Princeton 20, Navy 14 | Box score |
| Oct 14, 1950 | 15Rice 14, Pittsburgh 7 | Box score |
| Oct 14, 1950 | Rutgers 26, Temple 20 | Box score |
| Oct 14, 1950 | San Francisco 33, Saint Mary’s (CA) 7 | Box score |
| Oct 14, 1950 | 2SMU 56, Oklahoma State 0 | Box score |
| Oct 14, 1950 | 6Stanford 23, Santa Clara 13 | Box score |
| Oct 14, 1950 | Syracuse 27, Penn State 7 | Box score |
| Oct 14, 1950 | 14Tennessee 41, Chattanooga 0 | Box score |
| Oct 14, 1950 | Texas A&M 52, VMI 0 | Box score |
| Oct 14, 1950 | TCU 19, Texas Tech 6 | Box score |
| Oct 14, 1950 | UTEP 14, Arizona 13 | Box score |
| Oct 14, 1950 | Tulsa 27, Villanova 7upset | Box score |
| Oct 14, 1950 | Denver 14, Utah 14 | Box score |
| Oct 14, 1950 | 19Vanderbilt 20, Ole Miss 14 | Box score |
| Oct 14, 1950 | Virginia 26, Washington and Lee 21 | Box score |
| Oct 14, 1950 | Wake Forest 13, North Carolina 7 | Box score |
| Oct 14, 1950 | 11Washington 35, Oregon State 6 | Box score |
| Oct 14, 1950 | Washington State 14, Montana 7 | Box score |
| Oct 14, 1950 | West Texas 45, New Mexico 6 | Box score |
| Oct 14, 1950 | West Virginia 46, Richmond 7 | Box score |
| Oct 14, 1950 | Wichita State 34, Bradley 6 | Box score |
| Oct 14, 1950 | 15Wisconsin 14, Iowa 0 | Box score |
| Oct 14, 1950 | Wyoming 40, Utah State 7 | Box score |
| Oct 14, 1950 | Yale 20, Columbia 14 | Box score |