| Oct 24, 1940 | 13Clemson 21, South Carolina 13 | Box score |
| Oct 25, 1940 | Duquesne 10, Manhattan 6 | Box score |
| Oct 25, 1940 | George Washington 19, West Virginia 0 | Box score |
| Oct 25, 1940 | Georgia 7, Kentucky 7 | Box score |
| Oct 25, 1940 | Michigan State 0, Santa Clara 0 | Box score |
| Oct 26, 1940 | Arizona 24, Oklahoma State 0 | Box score |
| Oct 26, 1940 | UTEP 0, Arizona State 0 | Box score |
| Oct 26, 1940 | Arkansas 21, 14Ole Miss 20upset | Box score |
| Oct 26, 1940 | Auburn 16, Georgia Tech 7 | Box score |
| Oct 26, 1940 | Brown 9, Holy Cross 6 | Box score |
| Oct 26, 1940 | Colorado 62, Wyoming 0 | Box score |
| Oct 26, 1940 | Colorado State 7, New Mexico 6 | Box score |
| Oct 26, 1940 | 1Cornell 21, Ohio State 7 | Box score |
| Oct 26, 1940 | Dartmouth 7, Harvard 6 | Box score |
| Oct 26, 1940 | Duke 23, Wake Forest 0 | Box score |
| Oct 26, 1940 | 15Georgetown 26, New York University 0 | Box score |
| Oct 26, 1940 | Kansas State 20, Kansas 0 | Box score |
| Oct 26, 1940 | Lafayette 19, Army 0 | Box score |
| Oct 26, 1940 | LSU 7, Vanderbilt 0 | Box score |
| Oct 26, 1940 | 3Michigan 14, 8Pennsylvania 0 | Box score |
| Oct 26, 1940 | 6Minnesota 34, Iowa 6 | Box score |
| Oct 26, 1940 | Mississippi State 26, NC State 10 | Box score |
| Oct 26, 1940 | Montana 13, Gonzaga 10 | Box score |
| Oct 26, 1940 | Navy 21, Yale 0 | Box score |
| Oct 26, 1940 | 18Nebraska 20, Missouri 7 | Box score |
| Oct 26, 1940 | 7Northwestern 20, Indiana 7 | Box score |
| Oct 26, 1940 | 2Notre Dame 26, Illinois 0 | Box score |
| Oct 26, 1940 | Oklahoma 20, Iowa State 7 | Box score |
| Oct 26, 1940 | Washington State 6, Oregon 6 | Box score |
| Oct 26, 1940 | Oregon State 7, UCLA 0 | Box score |
| Oct 26, 1940 | Penn State 18, Temple 0 | Box score |
| Oct 26, 1940 | Rice 13, 12Texas 0upset | Box score |
| Oct 26, 1940 | Richmond 9, VMI 7upset | Box score |
| Oct 26, 1940 | Saint Louis 21, Drake 0 | Box score |
| Oct 26, 1940 | Saint Mary’s (CA) 9, 11Fordham 6upset | Box score |
| Oct 26, 1940 | 9Stanford 21, 17USC 7 | Box score |
| Oct 26, 1940 | Syracuse 3, 20Columbia 0upset | Box score |
| Oct 26, 1940 | 5Tennessee 14, Florida 0 | Box score |
| Oct 26, 1940 | 4Texas A&M 14, Baylor 7 | Box score |
| Oct 26, 1940 | Texas Tech 20, Marquette 13 | Box score |
| Oct 26, 1940 | Tulane 14, North Carolina 13upset | Box score |
| Oct 26, 1940 | Tulsa 7, TCU 0 | Box score |
| Oct 26, 1940 | Utah 25, Denver 14 | Box score |
| Oct 26, 1940 | Utah State 0, Idaho 0 | Box score |
| Oct 26, 1940 | Virginia Tech 21, Washington and Lee 0 | Box score |
| Oct 26, 1940 | 16Washington 7, California 6 | Box score |
| Oct 26, 1940 | William & Mary 13, Virginia 6 | Box score |
| Oct 26, 1940 | Wisconsin 14, Purdue 13upset | Box score |
| Oct 27, 1940 | San Francisco 0, Creighton 0 | Box score |
| Oct 27, 1940 | Detroit Mercy 10, Villanova 0 | Box score |