1921: Week 5
67 games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Oct 11, 1921 | Utah State 14, Wyoming 3 | Box score |
| Oct 12, 1921 | Texas A&M 13, SMU 0 | Box score |
| Oct 14, 1921 | Auburn 56, Clemson 0 | Box score |
| Oct 15, 1921 | Boston College 23, Baylor 7 | Box score |
| Oct 15, 1921 | Colorado College 7, New Mexico 0 | Box score |
| Oct 15, 1921 | Colorado State 14, Colorado School of Mines 0 | Box score |
| Oct 15, 1921 | Dartmouth 14, Tennessee 3 | Box score |
| Oct 15, 1921 | Drake 15, Kansas 7upset | Box score |
| Oct 15, 1921 | Florida 7, Mercer 0 | Box score |
| Oct 15, 1921 | Georgia Tech 69, Furman 0 | Box score |
| Oct 15, 1921 | Harvard 10, Georgia 7 | Box score |
| Oct 15, 1921 | Iowa 14, Illinois 2 | Box score |
| Oct 15, 1921 | Lafayette 20, Bucknell 7 | Box score |
| Oct 15, 1921 | LSU 6, Texas A&M 0 | Box score |
| Oct 15, 1921 | Michigan 30, Michigan State 0 | Box score |
| Oct 15, 1921 | Mississippi State 14, Mississippi College 13 | Box score |
| Oct 15, 1921 | Missouri 17, Iowa State 14 | Box score |
| Oct 15, 1921 | Navy 13, Princeton 0 | Box score |
| Oct 15, 1921 | South Carolina 7, North Carolina 7 | Box score |
| Oct 15, 1921 | Notre Dame 33, Purdue 0 | Box score |
| Oct 15, 1921 | Ohio State 27, Minnesota 0 | Box score |
| Oct 15, 1921 | Oklahoma 6, Oklahoma State 0 | Box score |
| Oct 15, 1921 | Idaho 7, Oregon 7 | Box score |
| Oct 15, 1921 | Rutgers 14, Washington and Lee 13upset | Box score |
| Oct 15, 1921 | Sewanee 21, Oglethorpe 0 | Box score |
| Oct 15, 1921 | Syracuse 28, Brown 0 | Box score |
| Oct 15, 1921 | Tulane 7, Rice 6 | Box score |
| Oct 15, 1921 | Utah 14, Wyoming 3 | Box score |
| Oct 15, 1921 | Utah State 30, Montana State 7 | Box score |
| Oct 15, 1921 | Vanderbilt 21, Kentucky 14 | Box score |
| Oct 15, 1921 | Virginia 14, VMI 7upset | Box score |
| Oct 15, 1921 | Virginia Tech 34, Richmond 0 | Box score |
| Oct 15, 1921 | Wake Forest 10, Davidson 7 | Box score |
| Oct 15, 1921 | Washington 28, Montana 7 | Box score |
| Oct 15, 1921 | Washington St. Louis 14, Grinnell 13 | Box score |
| Oct 15, 1921 | Wisconsin 27, Northwestern 0 | Box score |
Everyone else
| Oct 14, 1921 | Erskine 74, Charleston 0 | Box score |
| Oct 15, 1921 | Alabama 95, Bryson 0 | Box score |
| Oct 15, 1921 | Arkansas 28, Ouachita 0 | Box score |
| Oct 15, 1921 | Birmingham-Southern 19, Marion 0 | Box score |
| Oct 15, 1921 | California 21, Pacific Fleet 10 | Box score |
| Oct 15, 1921 | Centre 28, Xavier 6 | Box score |
| Oct 15, 1921 | Chattanooga 31, Georgetown (Kentucky) 0 | Box score |
| Oct 15, 1921 | The Citadel 20, Presbyterian 0 | Box score |
| Oct 15, 1921 | Colgate 21, Susquehanna 6 | Box score |
| Oct 15, 1921 | Columbia 19, New York University 0 | Box score |
| Oct 15, 1921 | Cornell 110, Western Reserve 0 | Box score |
| Oct 15, 1921 | Creighton 14, Kansas State 7upset | Box score |
| Oct 15, 1921 | Denver 21, Nebraska Wesleyan 3 | Box score |
| Oct 15, 1921 | Ole Miss 49, Millsaps 0 | Box score |
| Oct 15, 1921 | Nebraska 41, Haskell 0 | Box score |
| Oct 15, 1921 | Newberry 41, Charleston 0 | Box score |
| Oct 15, 1921 | Oregon State 54, Willamette 0 | Box score |
| Oct 15, 1921 | Penn State 28, Lehigh 7 | Box score |
| Oct 15, 1921 | Phillips 9, Hardin Simmons 0 | Box score |
| Oct 15, 1921 | Pittsburgh 21, Cincinnati 14 | Box score |
| Oct 15, 1921 | Spring Hill 28, Loyola (LA) 7 | Box score |
| Oct 15, 1921 | St. John’s (Maryland) 7, Maryland 3upset | Box score |
| Oct 15, 1921 | Stanford 7, Olympic Club 0 | Box score |
| Oct 15, 1921 | Pennsylvania 7, Swarthmore 7 | Box score |
| Oct 15, 1921 | Texas 21, Howard Payne 0 | Box score |
| Oct 15, 1921 | TCU 19, Trinity (Texas) 3 | Box score |
| Oct 15, 1921 | Washington & Jefferson 14, Carnegie Mellon 0 | Box score |
| Oct 15, 1921 | Washington State 54, Gonzaga 7 | Box score |
| Oct 15, 1921 | West Virginia 7, Ohio 0 | Box score |
| Oct 15, 1921 | Wofford 20, Elon 7 | Box score |
| Oct 15, 1921 | Yale 23, Williams 0 | Box score |