| Sep 26, 1905 | Minnesota 54, Shattuck 0 | Box score |
| Sep 27, 1905 | Brown 24, Massachusetts 0 | Box score |
| Sep 27, 1905 | Cornell 5, Hamilton 0 | Box score |
| Sep 27, 1905 | Pittsburgh 71, California (PA) 0 | Box score |
| Sep 27, 1905 | Syracuse 24, Hobart 0 | Box score |
| Sep 27, 1905 | Washington & Jefferson 23, Westminster (Pennsylvania) 0 | Box score |
| Sep 30, 1905 | Bates 6, Hebron Academy 0 | Box score |
| Sep 30, 1905 | Bowdoin 5, Camp Preble 0 | Box score |
| Sep 30, 1905 | Brown 42, WPI 0 | Box score |
| Sep 30, 1905 | Bucknell 27, Mansfield 0 | Box score |
| Sep 30, 1905 | Colorado 28, North Denver High 0 | Box score |
| Sep 30, 1905 | Colorado Springs High 6, Colorado College 0upset | Box score |
| Sep 30, 1905 | Columbia 23, Union (NY) 0 | Box score |
| Sep 30, 1905 | Denver 26, Sacred Heart 10 | Box score |
| Sep 30, 1905 | Dickinson 26, McDaniel 0 | Box score |
| Sep 30, 1905 | Drake 18, William Penn 6 | Box score |
| Sep 30, 1905 | Des Moines 0, Grinnell 0 | Box score |
| Sep 30, 1905 | Haskell 22, Buckner Business College 0 | Box score |
| Sep 30, 1905 | Holy Cross 17, Massachusetts 0 | Box score |
| Sep 30, 1905 | Indiana 31, Butler 0 | Box score |
| Sep 30, 1905 | Iowa 40, Monmouth 0 | Box score |
| Sep 30, 1905 | Lafayette 23, Wyoming Seminary 0 | Box score |
| Sep 30, 1905 | Lawrence 63, Actual Business College 0 | Box score |
| Sep 30, 1905 | Maine 22, Kents Hill 0 | Box score |
| Sep 30, 1905 | Michigan 65, Ohio Wesleyan 0 | Box score |
| Sep 30, 1905 | Minnesota 42, St. Thomas 0 | Box score |
| Sep 30, 1905 | Missouri 6, Truman State 0 | Box score |
| Sep 30, 1905 | Nebraska 20, Lincoln High 0 | Box score |
| Sep 30, 1905 | New Hampshire 6, Rhode Island 0 | Box score |
| Sep 30, 1905 | Northwestern 41, St. Viator 0 | Box score |
| Sep 30, 1905 | Notre Dame 44, North Division High 0 | Box score |
| Sep 30, 1905 | Penn State 29, California (PA) 0 | Box score |
| Sep 30, 1905 | Pennsylvania 35, Lehigh 0 | Box score |
| Sep 30, 1905 | Syracuse 16, Rochester (NY) 0 | Box score |
| Sep 30, 1905 | Tennessee 16, Tennessee Deaf School 6 | Box score |
| Sep 30, 1905 | Trinity (Texas) 22, Baylor 5 | Box score |
| Sep 30, 1905 | Vanderbilt 97, Maryville (TN) 0 | Box score |
| Sep 30, 1905 | Vermont 17, Fort Ethan Allen 0 | Box score |
| Sep 30, 1905 | Virginia 30, St. John’s (Maryland) 5 | Box score |
| Sep 30, 1905 | Virginia Tech 86, Roanoke 0 | Box score |
| Sep 30, 1905 | Washburn 39, Emporia College 0 | Box score |
| Sep 30, 1905 | Washington St. Louis 59, Westminster (Missouri) 0 | Box score |
| Sep 30, 1905 | Wesleyan (CT) 38, UConn 0 | Box score |
| Sep 30, 1905 | Wisconsin 49, North Central College 0 | Box score |
| Oct 1, 1905 | Lehigh 56, Gallaudet 0 | Box score |