| Sep 10, 2009 | Wagner 41, SUNY Maritime 10 | Box score |
| Sep 10, 2009 | Florida A&M 34, Winston-Salem State 10 | Box score |
| Sep 10, 2009 | SE Louisiana 69, Union College 20 | Box score |
| Sep 10, 2009 | Tennessee Tech 51, Pikeville 10 | Box score |
| Sep 12, 2009 | Eastern Illinois 31, Indiana State 0 | Box score |
| Sep 12, 2009 | Birmingham-Southern 35, Campbell 28 | Box score |
| Sep 12, 2009 | Holy Cross 52, Sacred Heart 21 | Box score |
| Sep 12, 2009 | Maine 17, Northeastern 7 | Box score |
| Sep 12, 2009 | Lenoir Rhyne 42, Davidson 0upset | Box score |
| Sep 12, 2009 | Urbana 13, Dayton 10upset | Box score |
| Sep 12, 2009 | Drake 34, Marist 6 | Box score |
| Sep 12, 2009 | Saint Francis 31, Morehead State 0upset | Box score |
| Sep 12, 2009 | Hofstra 40, Bryant 24 | Box score |
| Sep 12, 2009 | Butler 49, Franklin 19 | Box score |
| Sep 12, 2009 | Elon 41, Presbyterian 7 | Box score |
| Sep 12, 2009 | Valparaiso 20, Concordia (WI) 17 | Box score |
| Sep 12, 2009 | Akron 41, Morgan State 0 | Box score |
| Sep 12, 2009 | Nicholls 14, Duquesne 7 | Box score |
| Sep 12, 2009 | Montana State 23, Utah Tech 20 | Box score |
| Sep 12, 2009 | Richmond 16, Delaware 15 | Box score |
| Sep 12, 2009 | Rutgers 45, Howard 7 | Box score |
| Sep 12, 2009 | McNeese 40, App State 35upset | Box score |
| Sep 12, 2009 | Northern Colorado 31, San Diego 12upset | Box score |
| Sep 12, 2009 | South Carolina State 24, Bethune-Cookman 3 | Box score |
| Sep 12, 2009 | Missouri State 24, UT Martin 14 | Box score |
| Sep 12, 2009 | Youngstown State 38, Austin Peay 21 | Box score |
| Sep 12, 2009 | Portland State 34, Southern Oregon 10 | Box score |
| Sep 12, 2009 | Colorado State 24, Weber State 23 | Box score |
| Sep 12, 2009 | Arkansas–Pine Bluff 45, Langston 30 | Box score |
| Sep 12, 2009 | Alabama State 20, Savannah State 17 | Box score |
| Sep 12, 2009 | Northern Iowa 66, South Dakota 7 | Box score |
| Sep 12, 2009 | 10California 59, Eastern Washington 7 | Box score |
| Sep 12, 2009 | Lafayette 28, Georgetown 3 | Box score |
| Sep 12, 2009 | Florida State 19, Jacksonville State 9 | Box score |
| Sep 12, 2009 | Massachusetts 44, UAlbany 7 | Box score |
| Sep 12, 2009 | Maryland 38, James Madison 35 | Box score |
| Sep 12, 2009 | NC State 65, Murray State 7 | Box score |
| Sep 12, 2009 | Furman 38, Chattanooga 20 | Box score |
| Sep 12, 2009 | Old Dominion 49, Virginia Union 17 | Box score |
| Sep 12, 2009 | Bucknell 26, Robert Morris 23 | Box score |
| Sep 12, 2009 | Colgate 23, Stony Brook 13 | Box score |
| Sep 12, 2009 | North Carolina A&T 17, Norfolk State 13 | Box score |
| Sep 12, 2009 | Gardner-Webb 27, Western Carolina 20 | Box score |
| Sep 12, 2009 | 13Oklahoma 64, Idaho State 0 | Box score |
| Sep 12, 2009 | Villanova 38, Lehigh 17 | Box score |
| Sep 12, 2009 | Coastal Carolina 24, Monmouth 17 | Box score |
| Sep 12, 2009 | Illinois 45, Illinois State 17 | Box score |
| Sep 12, 2009 | Alabama A&M 31, Hampton 24 | Box score |
| Sep 12, 2009 | New Hampshire 23, Ball State 16upset | Box score |
| Sep 12, 2009 | Tennessee State 14, Jackson State 7 | Box score |
| Sep 12, 2009 | Liberty 35, North Carolina Central 10 | Box score |
| Sep 12, 2009 | UL Monroe 58, Texas Southern 0 | Box score |
| Sep 12, 2009 | Sam Houston 48, North Dakota State 45 | Box score |
| Sep 12, 2009 | Samford 27, Jacksonville 0 | Box score |
| Sep 12, 2009 | South Dakota State 44, Georgia Southern 6 | Box score |
| Sep 12, 2009 | Southern 68, Central State 0 | Box score |
| Sep 12, 2009 | Stephen F. Austin 92, Texas College 0 | Box score |
| Sep 12, 2009 | William & Mary 33, Central Connecticut 14 | Box score |
| Sep 12, 2009 | Wofford 42, Charleston Southern 14 | Box score |
| Sep 12, 2009 | Grambling 38, Northwestern State 17 | Box score |
| Sep 12, 2009 | Cal Poly 38, Sacramento State 19 | Box score |
| Sep 12, 2009 | 23Cincinnati 70, Southeast Missouri State 3 | Box score |
| Sep 12, 2009 | Northern Illinois 41, Western Illinois 7 | Box score |
| Sep 12, 2009 | New Mexico State 21, Prairie View A&M 18 | Box score |
| Sep 12, 2009 | San Diego State 35, Southern Utah 19 | Box score |
| Sep 12, 2009 | Arizona 34, Northern Arizona 17 | Box score |
| Sep 12, 2009 | Montana 17, UC Davis 10 | Box score |