| Oct 16, 2001 | Louisville 24, Southern Miss 14 | Box score |
| Oct 19, 2001 | Boise State 35, Fresno State 30upset | Box score |
| Oct 20, 2001 | UAB 34, Tulane 27 | Box score |
| Oct 20, 2001 | Arizona State 41, Oregon State 24 | Box score |
| Oct 20, 2001 | Auburn 48, Louisiana Tech 41 | Box score |
| Oct 20, 2001 | Ball State 24, Toledo 20upset | Box score |
| Oct 20, 2001 | Boston College 45, Pittsburgh 7 | Box score |
| Oct 20, 2001 | Bowling Green 16, Akron 11 | Box score |
| Oct 20, 2001 | BYU 63, Air Force 33 | Box score |
| Oct 20, 2001 | UCF 38, UL Monroe 6 | Box score |
| Oct 20, 2001 | Cincinnati 29, Houston 28 | Box score |
| Oct 20, 2001 | Colorado State 26, UNLV 24 | Box score |
| Oct 20, 2001 | East Carolina 32, Memphis 11 | Box score |
| Oct 20, 2001 | Florida State 43, Virginia 7 | Box score |
| Oct 20, 2001 | Georgia 43, Kentucky 29 | Box score |
| Oct 20, 2001 | Georgia Tech 27, NC State 17 | Box score |
| Oct 20, 2001 | Hawai’i 36, Tulsa 15 | Box score |
| Oct 20, 2001 | Illinois 42, Wisconsin 35 | Box score |
| Oct 20, 2001 | Iowa 42, Indiana 28 | Box score |
| Oct 20, 2001 | Iowa State 28, Oklahoma State 14 | Box score |
| Oct 20, 2001 | Kent State 35, Buffalo 13 | Box score |
| Oct 20, 2001 | Louisiana 54, Idaho 37upset | Box score |
| Oct 20, 2001 | LSU 42, Mississippi State 0 | Box score |
| Oct 20, 2001 | Marshall 42, Central Michigan 21 | Box score |
| Oct 20, 2001 | Maryland 59, Duke 17 | Box score |
| Oct 20, 2001 | Miami (OH) 36, Ohio 24 | Box score |
| Oct 20, 2001 | Minnesota 28, Michigan State 19 | Box score |
| Oct 20, 2001 | Ole Miss 45, Middle Tennessee 17 | Box score |
| Oct 20, 2001 | Missouri 38, Kansas 34 | Box score |
| Oct 20, 2001 | Nebraska 41, Texas Tech 31 | Box score |
| Oct 20, 2001 | North Carolina 38, Clemson 3upset | Box score |
| Oct 20, 2001 | North Texas 45, Arkansas State 0 | Box score |
| Oct 20, 2001 | Northern Illinois 20, Western Michigan 12upset | Box score |
| Oct 20, 2001 | Notre Dame 27, USC 16 | Box score |
| Oct 20, 2001 | Ohio State 27, San Diego State 12 | Box score |
| Oct 20, 2001 | Oklahoma 33, Baylor 17 | Box score |
| Oct 20, 2001 | Penn State 38, Northwestern 35upset | Box score |
| Oct 20, 2001 | Rice 33, Nevada 30 | Box score |
| Oct 20, 2001 | Rutgers 23, Navy 17 | Box score |
| Oct 20, 2001 | San José State 40, UTEP 28upset | Box score |
| Oct 20, 2001 | South Carolina 46, Vanderbilt 14 | Box score |
| Oct 20, 2001 | Stanford 49, Oregon 42upset | Box score |
| Oct 20, 2001 | Syracuse 45, Temple 3 | Box score |
| Oct 20, 2001 | Tennessee 35, Alabama 24 | Box score |
| Oct 20, 2001 | Texas 41, Colorado 7 | Box score |
| Oct 20, 2001 | Texas A&M 31, Kansas State 24 | Box score |
| Oct 20, 2001 | TCU 38, Army 20 | Box score |
| Oct 20, 2001 | UCLA 56, California 17 | Box score |
| Oct 20, 2001 | Utah 35, Wyoming 0 | Box score |
| Oct 20, 2001 | Washington 31, Arizona 28 | Box score |