| Oct 4, 2001 | Louisville 7, Colorado State 2 | Box score |
| Oct 5, 2001 | 20BYU 54, Utah State 34 | Box score |
| Oct 6, 2001 | 25Maryland 41, Virginia 21 | Box score |
| Oct 6, 2001 | Syracuse 24, Rutgers 17 | Box score |
| Oct 6, 2001 | 8Virginia Tech 35, West Virginia 0 | Box score |
| Oct 6, 2001 | 1Miami 38, Troy 7 | Box score |
| Oct 6, 2001 | Air Force 24, Navy 18 | Box score |
| Oct 6, 2001 | Hawai’i 38, SMU 31 | Box score |
| Oct 6, 2001 | Georgia 26, 6Tennessee 24upset | Box score |
| Oct 6, 2001 | Illinois 25, Minnesota 14 | Box score |
| Oct 6, 2001 | 21Purdue 23, Iowa 14 | Box score |
| Oct 6, 2001 | Colorado 16, 12Kansas State 6upset | Box score |
| Oct 6, 2001 | UConn 19, Eastern Michigan 0 | Box score |
| Oct 6, 2001 | 17Georgia Tech 37, Duke 10 | Box score |
| Oct 6, 2001 | Army 28, Houston 14 | Box score |
| Oct 6, 2001 | 13South Carolina 42, Kentucky 6 | Box score |
| Oct 6, 2001 | Bowling Green 24, Kent State 7 | Box score |
| Oct 6, 2001 | Miami (OH) 31, Buffalo 14 | Box score |
| Oct 6, 2001 | 24Texas A&M 16, Baylor 10 | Box score |
| Oct 6, 2001 | Indiana 63, Wisconsin 32upset | Box score |
| Oct 6, 2001 | Marshall 37, Northern Illinois 15 | Box score |
| Oct 6, 2001 | Notre Dame 24, Pittsburgh 7 | Box score |
| Oct 6, 2001 | New Mexico State 24, Tulsa 7 | Box score |
| Oct 6, 2001 | Alabama 56, UTEP 7 | Box score |
| Oct 6, 2001 | New Mexico 30, Wyoming 29 | Box score |
| Oct 6, 2001 | 2Florida 44, 18LSU 15 | Box score |
| Oct 6, 2001 | Boston College 33, Temple 10 | Box score |
| Oct 6, 2001 | 15Michigan 20, Penn State 0 | Box score |
| Oct 6, 2001 | 3Oklahoma 14, 5Texas 3 | Box score |
| Oct 6, 2001 | 11Washington 27, USC 24 | Box score |
| Oct 6, 2001 | North Carolina 24, East Carolina 21 | Box score |
| Oct 6, 2001 | UNLV 27, Nevada 12 | Box score |
| Oct 6, 2001 | Washington State 34, Oregon State 27 | Box score |
| Oct 6, 2001 | 23Toledo 48, Ohio 41 | Box score |
| Oct 6, 2001 | UCF 24, UAB 7 | Box score |
| Oct 6, 2001 | Western Michigan 31, Akron 14 | Box score |
| Oct 6, 2001 | NC State 17, Wake Forest 14 | Box score |
| Oct 6, 2001 | Auburn 16, Mississippi State 14 | Box score |
| Oct 6, 2001 | 4Nebraska 48, Iowa State 14 | Box score |
| Oct 6, 2001 | Ole Miss 35, Arkansas State 17 | Box score |
| Oct 6, 2001 | Cincinnati 46, Tulane 33 | Box score |
| Oct 6, 2001 | Louisiana Tech 41, San José State 20 | Box score |
| Oct 6, 2001 | Middle Tennessee 70, Idaho 58 | Box score |
| Oct 6, 2001 | UL Monroe 19, North Texas 17 | Box score |
| Oct 6, 2001 | Ohio State 38, 14Northwestern 20upset | Box score |
| Oct 6, 2001 | Missouri 41, Oklahoma State 38 | Box score |
| Oct 6, 2001 | Memphis 22, Southern Miss 17upset | Box score |
| Oct 6, 2001 | Rice 45, Boise State 14 | Box score |
| Oct 6, 2001 | Utah 52, South Florida 21 | Box score |
| Oct 6, 2001 | Kansas 34, Texas Tech 31upset | Box score |
| Oct 6, 2001 | Arizona State 63, Louisiana 27 | Box score |
| Oct 6, 2001 | 7Oregon 63, Arizona 28 | Box score |