| Nov 17, 1961 | Tulane 17, Vanderbilt 14 | Box score |
| Nov 17, 1961 | Virginia Tech 14, George Washington 3 | Box score |
| Nov 18, 1961 | Alabama 10, Georgia Tech 0 | Box score |
| Nov 18, 1961 | Arizona 48, UTEP 15 | Box score |
| Nov 18, 1961 | Arizona State 40, Detroit Mercy 6 | Box score |
| Nov 18, 1961 | Arkansas 21, SMU 7 | Box score |
| Nov 18, 1961 | Auburn 10, Georgia 7 | Box score |
| Nov 18, 1961 | Baylor 31, Air Force 7 | Box score |
| Nov 18, 1961 | Boston College 10, Boston University 7 | Box score |
| Nov 18, 1961 | Colorado 7, Nebraska 0 | Box score |
| Nov 18, 1961 | Columbia 37, Pennsylvania 6 | Box score |
| Nov 18, 1961 | Dartmouth 15, Cornell 14 | Box score |
| Nov 18, 1961 | Dayton 23, Wichita State 12upset | Box score |
| Nov 18, 1961 | Duke 6, North Carolina 3 | Box score |
| Nov 18, 1961 | Harvard 21, Brown 6 | Box score |
| Nov 18, 1961 | Idaho 16, Montana 14upset | Box score |
| Nov 18, 1961 | Indiana 17, West Virginia 9upset | Box score |
| Nov 18, 1961 | Iowa State 27, Tulsa 6 | Box score |
| Nov 18, 1961 | Kansas 53, California 7 | Box score |
| Nov 18, 1961 | Kentucky 9, Xavier 0 | Box score |
| Nov 18, 1961 | LSU 14, Mississippi State 6 | Box score |
| Nov 18, 1961 | Louisville 20, North Texas 0 | Box score |
| Nov 18, 1961 | Maryland 10, Wake Forest 7 | Box score |
| Nov 18, 1961 | Miami (OH) 7, Cincinnati 3 | Box score |
| Nov 18, 1961 | Michigan 23, Iowa 14 | Box score |
| Nov 18, 1961 | Michigan State 21, Northwestern 13 | Box score |
| Nov 18, 1961 | Minnesota 10, Purdue 7 | Box score |
| Nov 18, 1961 | Ole Miss 24, Tennessee 10 | Box score |
| Nov 18, 1961 | Missouri 27, Kansas State 9 | Box score |
| Nov 18, 1961 | Navy 13, Virginia 3 | Box score |
| Nov 18, 1961 | New Mexico 20, Colorado State 8 | Box score |
| Nov 18, 1961 | NC State 38, South Carolina 14 | Box score |
| Nov 18, 1961 | Notre Dame 17, Syracuse 15 | Box score |
| Nov 18, 1961 | Ohio State 22, Oregon 12 | Box score |
| Nov 18, 1961 | Oklahoma 14, Army 8upset | Box score |
| Nov 18, 1961 | Oklahoma State 28, Houston 24 | Box score |
| Nov 18, 1961 | Oregon State 35, BYU 0 | Box score |
| Nov 18, 1961 | Penn State 34, Holy Cross 14 | Box score |
| Nov 18, 1961 | Pittsburgh 10, USC 9 | Box score |
| Nov 18, 1961 | Princeton 26, Yale 16 | Box score |
| Nov 18, 1961 | Rice 21, Texas A&M 7 | Box score |
| Nov 18, 1961 | Rutgers 26, Colgate 6 | Box score |
| Nov 18, 1961 | Southern Miss 12, Florida State 0 | Box score |
| Nov 18, 1961 | TCU 6, Texas 0upset | Box score |
| Nov 18, 1961 | Utah State 17, Utah 6 | Box score |
| Nov 18, 1961 | Washington 17, UCLA 13 | Box score |
| Nov 18, 1961 | Washington State 30, Stanford 0 | Box score |
| Nov 18, 1961 | West Texas 35, New Mexico State 22upset | Box score |
| Nov 18, 1961 | Wisconsin 55, Illinois 7 | Box score |