| Nov 10, 1961 | Detroit Mercy 20, Villanova 6 | Box score |
| Nov 10, 1961 | UCLA 28, TCU 7 | Box score |
| Nov 11, 1961 | Air Force 15, California 14 | Box score |
| Nov 11, 1961 | Alabama 66, Richmond 0 | Box score |
| Nov 11, 1961 | Arizona 43, Idaho 7 | Box score |
| Nov 11, 1961 | Arizona State 48, UTEP 28 | Box score |
| Nov 11, 1961 | Arkansas 10, Rice 0 | Box score |
| Nov 11, 1961 | Army 48, William & Mary 13 | Box score |
| Nov 11, 1961 | BYU 30, Colorado State 16 | Box score |
| Nov 11, 1961 | Columbia 35, Dartmouth 14 | Box score |
| Nov 11, 1961 | Cornell 25, Brown 0 | Box score |
| Nov 11, 1961 | Duke 30, Navy 9 | Box score |
| Nov 11, 1961 | Florida 21, Georgia 14 | Box score |
| Nov 11, 1961 | Florida State 44, The Citadel 8 | Box score |
| Nov 11, 1961 | Harvard 9, Princeton 7 | Box score |
| Nov 11, 1961 | Houston 14, Tulsa 2 | Box score |
| Nov 11, 1961 | Kansas 34, Kansas State 0 | Box score |
| Nov 11, 1961 | Kentucky 16, Vanderbilt 3 | Box score |
| Nov 11, 1961 | LSU 30, North Carolina 0 | Box score |
| Nov 11, 1961 | Maryland 10, NC State 7 | Box score |
| Nov 11, 1961 | Memphis 41, North Texas 0 | Box score |
| Nov 11, 1961 | Miami 6, Tulane 0 | Box score |
| Nov 11, 1961 | Miami (OH) 48, Dayton 6 | Box score |
| Nov 11, 1961 | Michigan 38, Illinois 6 | Box score |
| Nov 11, 1961 | Minnesota 16, Iowa 9 | Box score |
| Nov 11, 1961 | Mississippi State 11, Auburn 10upset | Box score |
| Nov 11, 1961 | Nebraska 16, Iowa State 13upset | Box score |
| Nov 11, 1961 | Notre Dame 26, Pittsburgh 20 | Box score |
| Nov 11, 1961 | Ohio State 16, Indiana 7 | Box score |
| Nov 11, 1961 | Oklahoma 7, Missouri 0upset | Box score |
| Nov 11, 1961 | Oregon State 3, Washington 0upset | Box score |
| Nov 11, 1961 | Penn State 20, West Virginia 6 | Box score |
| Nov 11, 1961 | Purdue 7, Michigan State 6 | Box score |
| Nov 11, 1961 | San José State 29, Pacific 26 | Box score |
| Nov 11, 1961 | South Carolina 21, Clemson 14 | Box score |
| Nov 11, 1961 | USC 30, Stanford 15 | Box score |
| Nov 11, 1961 | Syracuse 51, Colgate 8 | Box score |
| Nov 11, 1961 | Tennessee 10, Georgia Tech 6 | Box score |
| Nov 11, 1961 | Texas 33, Baylor 7 | Box score |
| Nov 11, 1961 | Texas A&M 25, SMU 12 | Box score |
| Nov 11, 1961 | Texas Tech 14, Boston College 6 | Box score |
| Nov 11, 1961 | Utah 21, Colorado 12upset | Box score |
| Nov 11, 1961 | Utah State 65, Western Michigan 22 | Box score |
| Nov 11, 1961 | VMI 39, Buffalo 6 | Box score |
| Nov 11, 1961 | Wake Forest 24, Virginia Tech 15 | Box score |
| Nov 11, 1961 | Washington State 22, Oregon 21 | Box score |
| Nov 11, 1961 | Wichita State 26, Drake 13 | Box score |
| Nov 11, 1961 | Wisconsin 29, Northwestern 10upset | Box score |
| Nov 11, 1961 | Wyoming 33, New Mexico 7 | Box score |
| Nov 11, 1961 | Xavier 3, Marshall 2 | Box score |
| Nov 11, 1961 | Yale 23, Pennsylvania 0 | Box score |