| Nov 3, 1961 | Miami 32, Georgia 7 | Box score |
| Nov 4, 1961 | Air Force 14, Colorado State 9 | Box score |
| Nov 4, 1961 | Alabama 24, Mississippi State 0 | Box score |
| Nov 4, 1961 | Arizona 20, Wyoming 15 | Box score |
| Nov 4, 1961 | Arkansas 15, Texas A&M 8 | Box score |
| Nov 4, 1961 | Army 34, Detroit Mercy 7 | Box score |
| Nov 4, 1961 | Auburn 21, Wake Forest 7 | Box score |
| Nov 4, 1961 | Baylor 28, TCU 14 | Box score |
| Nov 4, 1961 | Boston College 14, Iowa State 10 | Box score |
| Nov 4, 1961 | Bowling Green 28, West Texas 6 | Box score |
| Nov 4, 1961 | The Citadel 14, VMI 8 | Box score |
| Nov 4, 1961 | Clemson 21, Tulane 6 | Box score |
| Nov 4, 1961 | Colorado 7, Missouri 6 | Box score |
| Nov 4, 1961 | Columbia 35, Cornell 7 | Box score |
| Nov 4, 1961 | Dartmouth 24, Yale 8 | Box score |
| Nov 4, 1961 | Georgia Tech 20, Florida 0 | Box score |
| Nov 4, 1961 | Harvard 37, Pennsylvania 6 | Box score |
| Nov 4, 1961 | Holy Cross 28, Dayton 0 | Box score |
| Nov 4, 1961 | Kansas 28, Nebraska 6 | Box score |
| Nov 4, 1961 | Kentucky 20, Florida State 0 | Box score |
| Nov 4, 1961 | LSU 10, Ole Miss 7 | Box score |
| Nov 4, 1961 | Maryland 21, Penn State 17 | Box score |
| Nov 4, 1961 | Michigan 28, Duke 14 | Box score |
| Nov 4, 1961 | Minnesota 13, Michigan State 0 | Box score |
| Nov 4, 1961 | Navy 13, Notre Dame 10 | Box score |
| Nov 4, 1961 | New Mexico 21, Utah 16 | Box score |
| Nov 4, 1961 | North Carolina 22, Tennessee 21 | Box score |
| Nov 4, 1961 | NC State 7, Southern Miss 6 | Box score |
| Nov 4, 1961 | North Texas 28, Drake 21 | Box score |
| Nov 4, 1961 | Northwestern 14, Indiana 8 | Box score |
| Nov 4, 1961 | Ohio State 29, Iowa 13 | Box score |
| Nov 4, 1961 | Oklahoma 17, Kansas State 6 | Box score |
| Nov 4, 1961 | Oregon 19, Stanford 7 | Box score |
| Nov 4, 1961 | Oregon State 14, Washington State 6 | Box score |
| Nov 4, 1961 | Pacific 27, Idaho 2 | Box score |
| Nov 4, 1961 | Princeton 52, Brown 0 | Box score |
| Nov 4, 1961 | Purdue 23, Illinois 9 | Box score |
| Nov 4, 1961 | Rice 42, Texas Tech 7 | Box score |
| Nov 4, 1961 | Richmond 11, Virginia Tech 0 | Box score |
| Nov 4, 1961 | San José State 32, Arizona State 26upset | Box score |
| Nov 4, 1961 | Washington 0, USC 0 | Box score |
| Nov 4, 1961 | Syracuse 28, Pittsburgh 9 | Box score |
| Nov 4, 1961 | Texas 27, SMU 0 | Box score |
| Nov 4, 1961 | UTEP 35, Hardin Simmons 7 | Box score |
| Nov 4, 1961 | Tulsa 19, Cincinnati 0 | Box score |
| Nov 4, 1961 | UCLA 35, California 15 | Box score |
| Nov 4, 1961 | Utah State 31, BYU 8 | Box score |
| Nov 4, 1961 | Virginia 28, South Carolina 20 | Box score |
| Nov 4, 1961 | West Virginia 12, George Washington 7 | Box score |
| Nov 4, 1961 | Wichita State 25, Oklahoma State 13 | Box score |
| Nov 4, 1961 | Xavier 16, Louisville 8 | Box score |