| Sep 26, 1958 | Air Force 37, Detroit Mercy 6upset | Box score |
| Sep 26, 1958 | Denver 20, Utah State 8 | Box score |
| Sep 26, 1958 | Georgia Tech 17, Florida State 3 | Box score |
| Sep 26, 1958 | Texas 21, Tulane 20 | Box score |
| Sep 26, 1958 | 14Wisconsin 20, 15Miami 0 | Box score |
| Sep 27, 1958 | 8Army 45, 18South Carolina 8 | Box score |
| Sep 27, 1958 | 3Auburn 13, Tennessee 0 | Box score |
| Sep 27, 1958 | Baylor 14, Hardin Simmons 7 | Box score |
| Sep 27, 1958 | BYU 14, Utah 7upset | Box score |
| Sep 27, 1958 | Brown 22, Columbia 0 | Box score |
| Sep 27, 1958 | Buffalo 6, Harvard 3upset | Box score |
| Sep 27, 1958 | Clemson 26, North Carolina 21 | Box score |
| Sep 27, 1958 | Colorado 13, Kansas State 3 | Box score |
| Sep 27, 1958 | Colorado State 21, Drake 0 | Box score |
| Sep 27, 1958 | Cornell 13, Colgate 0 | Box score |
| Sep 27, 1958 | Dayton 13, Richmond 12 | Box score |
| Sep 27, 1958 | Houston 39, Texas A&M 7 | Box score |
| Sep 27, 1958 | Iowa 17, 6TCU 0upset | Box score |
| Sep 27, 1958 | Iowa State 14, Arizona 0 | Box score |
| Sep 27, 1958 | 15LSU 13, Alabama 3 | Box score |
| Sep 27, 1958 | Maryland 21, NC State 6upset | Box score |
| Sep 27, 1958 | Michigan 20, USC 19 | Box score |
| Sep 27, 1958 | 4Michigan State 32, California 12 | Box score |
| Sep 27, 1958 | 9Ole Miss 27, 17Kentucky 6 | Box score |
| Sep 27, 1958 | 11Mississippi State 14, 18Florida 7 | Box score |
| Sep 27, 1958 | Missouri 14, Idaho 10 | Box score |
| Sep 27, 1958 | 12Navy 14, William & Mary 0 | Box score |
| Sep 27, 1958 | Northwestern 29, 10Washington State 28upset | Box score |
| Sep 27, 1958 | 5Notre Dame 18, Indiana 0 | Box score |
| Sep 27, 1958 | 1Ohio State 23, 20SMU 20 | Box score |
| Sep 27, 1958 | 2Oklahoma 47, 13West Virginia 14 | Box score |
| Sep 27, 1958 | Oklahoma State 21, North Texas 14 | Box score |
| Sep 27, 1958 | Oregon State 12, Kansas 0 | Box score |
| Sep 27, 1958 | Pacific 34, Arizona State 16 | Box score |
| Sep 27, 1958 | Penn State 43, Pennsylvania 0 | Box score |
| Sep 27, 1958 | 7Pittsburgh 17, Holy Cross 0 | Box score |
| Sep 27, 1958 | Purdue 28, Nebraska 0 | Box score |
| Sep 27, 1958 | Rice 30, Stanford 7 | Box score |
| Sep 27, 1958 | Rutgers 28, Princeton 0upset | Box score |
| Sep 27, 1958 | Syracuse 24, Boston College 14 | Box score |
| Sep 27, 1958 | Texas Tech 32, West Texas 7 | Box score |
| Sep 27, 1958 | UTEP 15, New Mexico 6 | Box score |
| Sep 27, 1958 | Tulsa 27, Arkansas 14upset | Box score |
| Sep 27, 1958 | UCLA 18, Illinois 14 | Box score |
| Sep 27, 1958 | Vanderbilt 21, Georgia 14 | Box score |
| Sep 27, 1958 | Virginia 15, Duke 12 | Box score |
| Sep 27, 1958 | VMI 33, Villanova 6 | Box score |
| Sep 27, 1958 | Wake Forest 13, Virginia Tech 6 | Box score |
| Sep 27, 1958 | Washington 24, Minnesota 21 | Box score |
| Sep 27, 1958 | Cincinnati 16, Wichita State 16 | Box score |
| Sep 27, 1958 | Wyoming 21, Montana 14 | Box score |