1958: Week 2
42 games. Three ranked teams lost, all to unranked teams. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Sep 19, 1958 | Detroit Mercy 21, George Washington 6 | Box score |
| Sep 19, 1958 | Oklahoma State 31, Denver 14 | Box score |
| Sep 19, 1958 | USC 21, 12Oregon State 0upset | Box score |
| Sep 20, 1958 | Arizona 7, Utah State 6 | Box score |
| Sep 20, 1958 | Baylor 12, Arkansas 0 | Box score |
| Sep 20, 1958 | Bowling Green 20, Wichita State 14 | Box score |
| Sep 20, 1958 | Cincinnati 14, Dayton 0 | Box score |
| Sep 20, 1958 | 18Clemson 20, Virginia 15 | Box score |
| Sep 20, 1958 | Florida 34, Tulane 14 | Box score |
| Sep 20, 1958 | Hardin Simmons 14, Tulsa 0 | Box score |
| Sep 20, 1958 | Iowa State 33, Drake 0 | Box score |
| Sep 20, 1958 | Kansas State 17, Wyoming 14 | Box score |
| Sep 20, 1958 | Kentucky 13, Georgia Tech 0 | Box score |
| Sep 20, 1958 | LSU 26, Rice 6upset | Box score |
| Sep 20, 1958 | 6Ole Miss 17, Memphis 0 | Box score |
| Sep 20, 1958 | Nebraska 14, Penn State 7upset | Box score |
| Sep 20, 1958 | New Mexico 16, New Mexico State 7 | Box score |
| Sep 20, 1958 | NC State 21, 10North Carolina 14upset | Box score |
| Sep 20, 1958 | North Texas 26, UTEP 8 | Box score |
| Sep 20, 1958 | Oregon 27, Idaho 0 | Box score |
| Sep 20, 1958 | Pacific 24, California 20 | Box score |
| Sep 20, 1958 | 19Pittsburgh 27, UCLA 6 | Box score |
| Sep 20, 1958 | South Carolina 8, Duke 0 | Box score |
| Sep 20, 1958 | 11Texas 13, Georgia 8 | Box score |
| Sep 20, 1958 | 8TCU 42, Kansas 0 | Box score |
| Sep 20, 1958 | Texas Tech 15, 20Texas A&M 14upset | Box score |
| Sep 20, 1958 | Utah 20, Montana 6 | Box score |
| Sep 20, 1958 | Vanderbilt 12, Missouri 8 | Box score |
| Sep 20, 1958 | Virginia Tech 28, West Texas 12 | Box score |
| Sep 20, 1958 | Wake Forest 34, Maryland 0 | Box score |
| Sep 20, 1958 | Washington 14, San José State 6 | Box score |
| Sep 20, 1958 | Washington State 40, Stanford 6 | Box score |
| Sep 20, 1958 | West Virginia 66, Richmond 22 | Box score |
Everyone else
| Sep 19, 1958 | Catawba 22, Davidson 17 | Box score |
| Sep 20, 1958 | Arizona State 47, Hawai’i 6 | Box score |
| Sep 20, 1958 | Boston College 48, Scranton 0 | Box score |
| Sep 20, 1958 | BYU 29, Fresno State 7 | Box score |
| Sep 20, 1958 | Florida State 42, Furman 6 | Box score |
| Sep 20, 1958 | Marquette 18, South Dakota State 7 | Box score |
| Sep 20, 1958 | Newberry 16, The Citadel 0upset | Box score |
| Sep 20, 1958 | Villanova 28, West Chester 14 | Box score |
| Sep 20, 1958 | VMI 46, Morehead State 20 | Box score |