1949: Week 12
39 games. Three ranked teams lost. Three games matched two ranked teams. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Nov 24, 1949 | 20Cornell 29, Pennsylvania 21 | Box score |
| Nov 24, 1949 | Detroit Mercy 33, Wichita State 7 | Box score |
| Nov 24, 1949 | 15Maryland 47, West Virginia 7 | Box score |
| Nov 24, 1949 | Missouri 34, Kansas State 27 | Box score |
| Nov 24, 1949 | Texas 42, Texas A&M 14 | Box score |
| Nov 24, 1949 | Utah 34, Utah State 0 | Box score |
| Nov 24, 1949 | Virginia Tech 28, VMI 28 | Box score |
| Nov 24, 1949 | Washington and Lee 35, Richmond 14 | Box score |
| Nov 24, 1949 | Wyoming 25, Denver 6 | Box score |
| Nov 25, 1949 | 20Kentucky 21, Miami 6 | Box score |
| Nov 26, 1949 | Alabama 35, Florida 13 | Box score |
| Nov 26, 1949 | Arkansas 40, Tulsa 7 | Box score |
| Nov 26, 1949 | 4Army 38, Navy 0 | Box score |
| Nov 26, 1949 | Boston College 76, Holy Cross 0 | Box score |
| Nov 26, 1949 | Brown 41, Colgate 26 | Box score |
| Nov 26, 1949 | The Citadel 25, Davidson 19 | Box score |
| Nov 26, 1949 | Clemson 20, Auburn 20 | Box score |
| Nov 26, 1949 | Colorado State 14, Colorado 7 | Box score |
| Nov 26, 1949 | Fordham 34, New York University 6 | Box score |
| Nov 26, 1949 | Georgia Tech 7, Georgia 6 | Box score |
| Nov 26, 1949 | Kansas 46, Arizona 0 | Box score |
| Nov 26, 1949 | 13LSU 21, 10Tulane 0upset | Box score |
| Nov 26, 1949 | Loyola Marymount 27, Arizona State 7upset | Box score |
| Nov 26, 1949 | Ole Miss 26, Mississippi State 0 | Box score |
| Nov 26, 1949 | 19North Carolina 14, Virginia 7 | Box score |
| Nov 26, 1949 | 1Notre Dame 32, 17USC 0 | Box score |
| Nov 26, 1949 | 3Oklahoma 41, Oklahoma State 0 | Box score |
| Nov 26, 1949 | 7Rice 21, 9Baylor 7 | Box score |
| Nov 26, 1949 | South Carolina 27, Wake Forest 20 | Box score |
| Nov 26, 1949 | 18Tennessee 26, Vanderbilt 20 | Box score |
| Nov 26, 1949 | TCU 21, SMU 13 | Box score |
| Nov 26, 1949 | Texas Tech 23, Hardin Simmons 13 | Box score |
| Nov 26, 1949 | UTEP 69, New Mexico State 7 | Box score |
| Nov 26, 1949 | West Texas 41, New Mexico 13 | Box score |
| Nov 26, 1949 | William & Mary 33, NC State 7 | Box score |