| Oct 18, 1946 | Detroit Mercy 20, 20Tulsa 14upset | Box score |
| Oct 18, 1946 | Hardin Simmons 49, New Mexico 0 | Box score |
| Oct 18, 1946 | Maryland 6, Virginia Tech 0 | Box score |
| Oct 18, 1946 | Temple 6, West Virginia 0 | Box score |
| Oct 19, 1946 | 1Army 48, 11Columbia 14 | Box score |
| Oct 19, 1946 | BYU 10, Colorado 7upset | Box score |
| Oct 19, 1946 | Brown 20, Dartmouth 13 | Box score |
| Oct 19, 1946 | Colgate 47, Merchant Marine 7 | Box score |
| Oct 19, 1946 | Denver 20, Utah 14 | Box score |
| Oct 19, 1946 | 17Duke 41, Richmond 0 | Box score |
| Oct 19, 1946 | Furman 14, The Citadel 0upset | Box score |
| Oct 19, 1946 | 8Georgia 33, Oklahoma State 13 | Box score |
| Oct 19, 1946 | Georgia Tech 26, 12LSU 7upset | Box score |
| Oct 19, 1946 | Illinois 27, 20Wisconsin 21upset | Box score |
| Oct 19, 1946 | Iowa 13, 18Indiana 0upset | Box score |
| Oct 19, 1946 | Kentucky 10, Vanderbilt 7 | Box score |
| Oct 19, 1946 | Miami 20, Florida 13 | Box score |
| Oct 19, 1946 | Michigan State 19, Penn State 16upset | Box score |
| Oct 19, 1946 | Minnesota 46, Wyoming 0 | Box score |
| Oct 19, 1946 | Mississippi State 48, San Francisco 20 | Box score |
| Oct 19, 1946 | Missouri 33, Iowa State 13 | Box score |
| Oct 19, 1946 | Montana 20, Montana State 7 | Box score |
| Oct 19, 1946 | Nebraska 16, Kansas 14upset | Box score |
| Oct 19, 1946 | 15North Carolina 21, Navy 14 | Box score |
| Oct 19, 1946 | NC State 14, Wake Forest 6upset | Box score |
| Oct 19, 1946 | 5Michigan 14, 10Northwestern 14 | Box score |
| Oct 19, 1946 | 13Oklahoma 28, Kansas State 7 | Box score |
| Oct 19, 1946 | 6Pennsylvania 40, Virginia 0 | Box score |
| Oct 19, 1946 | Pittsburgh 7, Marquette 6 | Box score |
| Oct 19, 1946 | Portland 13, Arizona State 0upset | Box score |
| Oct 19, 1946 | Princeton 14, Rutgers 7 | Box score |
| Oct 19, 1946 | Ohio State 14, Purdue 14 | Box score |
| Oct 19, 1946 | 16Rice 21, SMU 7 | Box score |
| Oct 19, 1946 | Saint Louis 27, Drake 6upset | Box score |
| Oct 19, 1946 | Saint Mary’s (CA) 33, Fordham 2 | Box score |
| Oct 19, 1946 | USC 28, Washington 0 | Box score |
| Oct 19, 1946 | Stanford 33, Santa Clara 26 | Box score |
| Oct 19, 1946 | Syracuse 21, Holy Cross 12upset | Box score |
| Oct 19, 1946 | 9Tennessee 12, 7Alabama 0upset | Box score |
| Oct 19, 1946 | 3Texas 20, 14Arkansas 0 | Box score |
| Oct 19, 1946 | Texas A&M 14, TCU 0 | Box score |
| Oct 19, 1946 | Texas Tech 13, Baylor 6 | Box score |
| Oct 19, 1946 | UTEP 26, West Texas 20 | Box score |
| Oct 19, 1946 | Tulane 32, Auburn 0 | Box score |
| Oct 19, 1946 | 4UCLA 13, California 6 | Box score |
| Oct 19, 1946 | Utah State 48, Colorado State 0 | Box score |
| Oct 19, 1946 | Villanova 19, Georgetown 2 | Box score |
| Oct 19, 1946 | VMI 25, Davidson 0 | Box score |
| Oct 19, 1946 | Oregon 0, Washington State 0 | Box score |
| Oct 19, 1946 | 19William & Mary 34, Washington and Lee 18 | Box score |
| Oct 19, 1946 | Cornell 6, Yale 6 | Box score |