| Oct 18, 1941 | Alabama 9, Tennessee 2upset | Box score |
| Oct 18, 1941 | Arizona 31, New Mexico 6 | Box score |
| Oct 18, 1941 | Arizona State 19, New Mexico State 14 | Box score |
| Oct 18, 1941 | Boston College 26, Manhattan 13 | Box score |
| Oct 18, 1941 | Utah 6, BYU 6 | Box score |
| Oct 18, 1941 | Colorado 26, Colorado State 13 | Box score |
| Oct 18, 1941 | Creighton 14, Washington St. Louis 13 | Box score |
| Oct 18, 1941 | Denver 40, Wyoming 0 | Box score |
| Oct 18, 1941 | Detroit Mercy 20, Oklahoma State 14 | Box score |
| Oct 18, 1941 | 3Duke 27, Colgate 14 | Box score |
| Oct 18, 1941 | Georgia 7, 20Columbia 3upset | Box score |
| Oct 18, 1941 | Harvard 7, Dartmouth 0 | Box score |
| Oct 18, 1941 | Illinois 40, Drake 0 | Box score |
| Oct 18, 1941 | Indiana 21, 15Nebraska 13upset | Box score |
| Oct 18, 1941 | LSU 27, 12Rice 0upset | Box score |
| Oct 18, 1941 | Loyola Marymount 20, UTEP 6upset | Box score |
| Oct 18, 1941 | Marquette 33, Kansas 7 | Box score |
| Oct 18, 1941 | Maryland 13, Florida 12 | Box score |
| Oct 18, 1941 | 6Michigan 14, 5Northwestern 7upset | Box score |
| Oct 18, 1941 | 1Minnesota 39, Pittsburgh 0 | Box score |
| Oct 18, 1941 | Ole Miss 21, Holy Cross 0 | Box score |
| Oct 18, 1941 | Missouri 39, Iowa State 13 | Box score |
| Oct 18, 1941 | 10Ohio State 16, Purdue 14 | Box score |
| Oct 18, 1941 | Oklahoma 16, Kansas State 0 | Box score |
| Oct 18, 1941 | Oregon 19, California 7 | Box score |
| Oct 18, 1941 | 11Pennsylvania 23, Princeton 0 | Box score |
| Oct 18, 1941 | 9Santa Clara 7, Michigan State 0 | Box score |
| Oct 18, 1941 | USC 7, Washington State 6 | Box score |
| Oct 18, 1941 | SMU 20, Auburn 7 | Box score |
| Oct 18, 1941 | Stanford 42, San Francisco 26 | Box score |
| Oct 18, 1941 | Syracuse 31, New York University 0 | Box score |
| Oct 18, 1941 | Temple 14, Penn State 0 | Box score |
| Oct 18, 1941 | 2Texas 48, Arkansas 14 | Box score |
| Oct 18, 1941 | 14Texas A&M 14, TCU 0 | Box score |
| Oct 18, 1941 | Texas Tech 25, Centenary (LA) 0 | Box score |
| Oct 18, 1941 | 17Tulane 52, North Carolina 6 | Box score |
| Oct 18, 1941 | Tulsa 33, Saint Louis 7 | Box score |
| Oct 18, 1941 | 18Vanderbilt 14, Georgia Tech 7 | Box score |
| Oct 18, 1941 | Villanova 14, Baylor 6 | Box score |
| Oct 18, 1941 | Virginia Tech 16, Davidson 0 | Box score |
| Oct 18, 1941 | Wake Forest 7, NC State 0 | Box score |
| Oct 18, 1941 | Washington 14, UCLA 7 | Box score |
| Oct 18, 1941 | Wisconsin 23, Iowa 0 | Box score |