| Oct 23, 1941 | South Carolina 18, 14Clemson 14upset | Box score |
| Oct 24, 1941 | Arkansas 9, Detroit Mercy 6upset | Box score |
| Oct 24, 1941 | San Francisco 25, BYU 13 | Box score |
| Oct 24, 1941 | Texas Tech 36, New Mexico 0 | Box score |
| Oct 25, 1941 | Alabama 27, Georgia 14 | Box score |
| Oct 25, 1941 | Arizona 20, Arizona State 7 | Box score |
| Oct 25, 1941 | Army 13, Columbia 0 | Box score |
| Oct 25, 1941 | California 14, USC 0 | Box score |
| Oct 25, 1941 | Colorado 27, Wyoming 0 | Box score |
| Oct 25, 1941 | Colorado State 7, Utah State 6 | Box score |
| Oct 25, 1941 | Creighton 12, Drake 7 | Box score |
| Oct 25, 1941 | 4Duke 27, Pittsburgh 7 | Box score |
| Oct 25, 1941 | Duquesne 31, Marquette 14 | Box score |
| Oct 25, 1941 | Georgia Tech 28, Auburn 14 | Box score |
| Oct 25, 1941 | Hardin Simmons 44, UTEP 14 | Box score |
| Oct 25, 1941 | Holy Cross 13, New York University 0 | Box score |
| Oct 25, 1941 | Kansas 13, Iowa State 0 | Box score |
| Oct 25, 1941 | Kentucky 18, West Virginia 6 | Box score |
| Oct 25, 1941 | LSU 10, Florida 7 | Box score |
| Oct 25, 1941 | Manhattan 9, 19Villanova 6upset | Box score |
| Oct 25, 1941 | 1Minnesota 7, 3Michigan 0 | Box score |
| Oct 25, 1941 | Ole Miss 20, 10Tulane 13upset | Box score |
| Oct 25, 1941 | Missouri 6, Nebraska 0 | Box score |
| Oct 25, 1941 | Harvard 0, 5Navy 0 | Box score |
| Oct 25, 1941 | 13Northwestern 14, 11Ohio State 7upset | Box score |
| Oct 25, 1941 | 7Notre Dame 49, Illinois 14 | Box score |
| Oct 25, 1941 | Oklahoma 16, 8Santa Clara 6upset | Box score |
| Oct 25, 1941 | 12Pennsylvania 55, Maryland 6 | Box score |
| Oct 25, 1941 | Purdue 7, Iowa 6 | Box score |
| Oct 25, 1941 | Saint Mary’s (CA) 20, Loyola Marymount 13 | Box score |
| Oct 25, 1941 | 19Stanford 13, Washington 7 | Box score |
| Oct 25, 1941 | 17Temple 41, Bucknell 14 | Box score |
| Oct 25, 1941 | Tennessee 21, Cincinnati 6 | Box score |
| Oct 25, 1941 | 2Texas 40, Rice 0 | Box score |
| Oct 25, 1941 | 9Texas A&M 48, Baylor 0 | Box score |
| Oct 25, 1941 | Tulsa 16, Oklahoma State 0 | Box score |
| Oct 25, 1941 | UCLA 14, 16Oregon 7upset | Box score |
| Oct 25, 1941 | Denver 0, Utah 0 | Box score |
| Oct 25, 1941 | 15Vanderbilt 46, Princeton 7 | Box score |
| Oct 25, 1941 | Virginia Tech 13, Washington and Lee 3 | Box score |
| Oct 25, 1941 | Wake Forest 13, North Carolina 0 | Box score |
| Oct 25, 1941 | Washington St. Louis 13, Centenary (LA) 7 | Box score |
| Oct 25, 1941 | Washington State 7, 18Oregon State 0upset | Box score |
| Oct 25, 1941 | William & Mary 48, George Washington 0 | Box score |
| Oct 25, 1941 | Wisconsin 27, Indiana 25 | Box score |