| Oct 3, 1917 | Alabama 7, Ohio Am. Corp. 0 | Box score |
| Oct 3, 1917 | Pennsylvania 73, Albright 10 | Box score |
| Oct 5, 1917 | Mississippi State 18, Marion 6 | Box score |
| Oct 6, 1917 | Arkansas 34, Central Missouri 0 | Box score |
| Oct 6, 1917 | Ole Miss 0, Arkansas State 0 | Box score |
| Oct 6, 1917 | Army 28, Carnegie Mellon 0 | Box score |
| Oct 6, 1917 | Auburn 53, Samford 0 | Box score |
| Oct 6, 1917 | Baylor 17, Howard Payne 0 | Box score |
| Oct 6, 1917 | Brown 20, Johns Hopkins 0 | Box score |
| Oct 6, 1917 | Bucknell 16, Swarthmore 7 | Box score |
| Oct 6, 1917 | California 40, Olympic Club 0 | Box score |
| Oct 6, 1917 | Carlisle 63, Franklin & Marshall 0 | Box score |
| Oct 6, 1917 | The Citadel 19, Charleston Navy 7 | Box score |
| Oct 6, 1917 | Colorado 54, Northern Colorado 0 | Box score |
| Oct 6, 1917 | Dartmouth 14, Springfield 0 | Box score |
| Oct 6, 1917 | Denver 45, Camp Logan 0 | Box score |
| Oct 6, 1917 | Drury 14, Tulsa 13 | Box score |
| Oct 6, 1917 | Georgetown 33, Lebanon Valley 7 | Box score |
| Oct 6, 1917 | Indiana 51, Wabash 0 | Box score |
| Oct 6, 1917 | Iowa 22, Cornell (IA) 13 | Box score |
| Oct 6, 1917 | Iowa State 7, Coe 0 | Box score |
| Oct 6, 1917 | Kentucky 19, Maryville (TN) 0 | Box score |
| Oct 6, 1917 | Lafayette 20, Army Ambulance Corps 0 | Box score |
| Oct 6, 1917 | Lehigh 13, Ursinus 7 | Box score |
| Oct 6, 1917 | LSU 20, Louisiana 6 | Box score |
| Oct 6, 1917 | Maryland 20, Delaware 0 | Box score |
| Oct 6, 1917 | Michigan 41, Case 0 | Box score |
| Oct 6, 1917 | Missouri 14, William Jewell 6 | Box score |
| Oct 6, 1917 | Nebraska 100, Nebraska Wesleyan 0 | Box score |
| Oct 6, 1917 | Northwestern 48, Lake Forest 0 | Box score |
| Oct 6, 1917 | Notre Dame 55, Kalamazoo 0 | Box score |
| Oct 6, 1917 | Ohio State 53, Ohio Wesleyan 0 | Box score |
| Oct 6, 1917 | Oklahoma 52, Phillips 9 | Box score |
| Oct 6, 1917 | Penn State 80, Gettysburg 0 | Box score |
| Oct 6, 1917 | Pittsburgh 40, Bethany (WV) 0 | Box score |
| Oct 6, 1917 | Presbyterian 55, Bailey Military 0 | Box score |
| Oct 6, 1917 | Purdue 54, Franklin 0 | Box score |
| Oct 6, 1917 | Rice 31, Illinois Medical 6 | Box score |
| Oct 6, 1917 | Rutgers 90, Camp Wadsworth 0 | Box score |
| Oct 6, 1917 | SMU 20, Meridian 7 | Box score |
| Oct 6, 1917 | Syracuse 19, 47th Infantry 0 | Box score |
| Oct 6, 1917 | Texas 27, Trinity (Texas) 0 | Box score |
| Oct 6, 1917 | Texas A&M 66, Austin 0 | Box score |
| Oct 6, 1917 | TCU 14, 1st Texas Artillery 7 | Box score |
| Oct 6, 1917 | Tulane 32, Jefferson 0 | Box score |
| Oct 6, 1917 | Utah State 77, Granite High 0 | Box score |
| Oct 6, 1917 | Vanderbilt 41, Transylvania 0 | Box score |
| Oct 6, 1917 | Virginia Tech 12, Hampden Sydney 0 | Box score |
| Oct 6, 1917 | Washington & Jefferson 36, Westminster (Pennsylvania) 0 | Box score |
| Oct 6, 1917 | Washington St. Louis 26, Lombard 14 | Box score |
| Oct 6, 1917 | Drake 7, William Penn 7 | Box score |
| Oct 6, 1917 | Williams 14, Cornell 10upset | Box score |
| Oct 6, 1917 | Wisconsin 34, Beloit 0 | Box score |
| Oct 6, 1917 | Wofford 20, Guilford 0 | Box score |