| Oct 19, 2000 | East Carolina 28, Louisville 25 | Box score |
| Oct 21, 2000 | UAB 14, Middle Tennessee 9 | Box score |
| Oct 21, 2000 | Arizona State 23, Washington State 20 | Box score |
| Oct 21, 2000 | Army 21, Tulane 17 | Box score |
| Oct 21, 2000 | Auburn 38, Louisiana Tech 28 | Box score |
| Oct 21, 2000 | Ball State 44, Buffalo 35 | Box score |
| Oct 21, 2000 | Boise State 59, North Texas 0 | Box score |
| Oct 21, 2000 | Bowling Green 20, Eastern Michigan 6 | Box score |
| Oct 21, 2000 | UCF 55, UL Monroe 0 | Box score |
| Oct 21, 2000 | 5Clemson 38, North Carolina 24 | Box score |
| Oct 21, 2000 | Colorado State 24, Utah 17 | Box score |
| Oct 21, 2000 | UConn 38, Akron 35upset | Box score |
| Oct 21, 2000 | 6Florida State 37, Virginia 3 | Box score |
| Oct 21, 2000 | 12Georgia 34, Kentucky 30 | Box score |
| Oct 21, 2000 | Georgia Tech 45, Duke 10 | Box score |
| Oct 21, 2000 | Houston 33, Memphis 30upset | Box score |
| Oct 21, 2000 | Indiana 51, 22Minnesota 43upset | Box score |
| Oct 21, 2000 | Kansas 23, Colorado 15 | Box score |
| Oct 21, 2000 | 10Kansas State 28, Texas Tech 23 | Box score |
| Oct 21, 2000 | LSU 45, 13Mississippi State 38upset | Box score |
| Oct 21, 2000 | Marshall 34, Kent State 12 | Box score |
| Oct 21, 2000 | Maryland 37, Wake Forest 7 | Box score |
| Oct 21, 2000 | 4Miami 45, Temple 17 | Box score |
| Oct 21, 2000 | 16Michigan 14, Michigan State 0 | Box score |
| Oct 21, 2000 | 1Nebraska 59, Baylor 0 | Box score |
| Oct 21, 2000 | UNLV 42, Wyoming 23 | Box score |
| Oct 21, 2000 | New Mexico 29, Air Force 23upset | Box score |
| Oct 21, 2000 | New Mexico State 35, Arkansas State 29 | Box score |
| Oct 21, 2000 | 20Notre Dame 42, West Virginia 28 | Box score |
| Oct 21, 2000 | Ohio 52, Central Michigan 3 | Box score |
| Oct 21, 2000 | 14Ohio State 38, Iowa 10 | Box score |
| Oct 21, 2000 | 7Oregon 14, 21Arizona 10 | Box score |
| Oct 21, 2000 | 19Oregon State 44, 23UCLA 38 | Box score |
| Oct 21, 2000 | Penn State 39, Illinois 25 | Box score |
| Oct 21, 2000 | Pittsburgh 42, Boston College 26 | Box score |
| Oct 21, 2000 | 17Purdue 30, Wisconsin 24 | Box score |
| Oct 21, 2000 | Rice 38, Hawai’i 13 | Box score |
| Oct 21, 2000 | Rutgers 28, Navy 21 | Box score |
| Oct 21, 2000 | San Diego State 16, BYU 15upset | Box score |
| Oct 21, 2000 | San José State 49, Nevada 30 | Box score |
| Oct 21, 2000 | 18South Carolina 30, Vanderbilt 14 | Box score |
| Oct 21, 2000 | Stanford 32, USC 30 | Box score |
| Oct 21, 2000 | Tennessee 20, Alabama 10 | Box score |
| Oct 21, 2000 | Texas 46, Missouri 12 | Box score |
| Oct 21, 2000 | Texas A&M 30, Iowa State 7 | Box score |
| Oct 21, 2000 | 11TCU 17, Tulsa 3 | Box score |
| Oct 21, 2000 | UTEP 23, Fresno State 13 | Box score |
| Oct 21, 2000 | Utah State 31, Idaho 14 | Box score |
| Oct 21, 2000 | 2Virginia Tech 22, Syracuse 14 | Box score |
| Oct 21, 2000 | 9Washington 36, California 24 | Box score |
| Oct 21, 2000 | Western Michigan 52, Northern Illinois 22 | Box score |