| Oct 26, 2000 | BYU 19, Wyoming 7 | Box score |
| Oct 28, 2000 | UAB 16, East Carolina 13upset | Box score |
| Oct 28, 2000 | 25Auburn 21, Arkansas 19 | Box score |
| Oct 28, 2000 | Ball State 38, Central Michigan 34 | Box score |
| Oct 28, 2000 | Boise State 34, New Mexico State 31 | Box score |
| Oct 28, 2000 | Boston College 42, Rutgers 13 | Box score |
| Oct 28, 2000 | California 28, USC 16upset | Box score |
| Oct 28, 2000 | UCF 40, Alabama 38upset | Box score |
| Oct 28, 2000 | Cincinnati 45, Miami (OH) 15 | Box score |
| Oct 28, 2000 | Colorado 37, Oklahoma State 21 | Box score |
| Oct 28, 2000 | Colorado State 34, San Diego State 22 | Box score |
| Oct 28, 2000 | 8Florida 34, 13Georgia 23 | Box score |
| Oct 28, 2000 | 6Florida State 58, 21NC State 14 | Box score |
| Oct 28, 2000 | Fresno State 34, Tulsa 12 | Box score |
| Oct 28, 2000 | Georgia Tech 31, 5Clemson 28upset | Box score |
| Oct 28, 2000 | Iowa State 39, Missouri 20 | Box score |
| Oct 28, 2000 | Louisville 35, Tulane 32 | Box score |
| Oct 28, 2000 | Marshall 31, Akron 28 | Box score |
| Oct 28, 2000 | Maryland 20, Duke 9 | Box score |
| Oct 28, 2000 | 4Miami 42, Louisiana Tech 31 | Box score |
| Oct 28, 2000 | Michigan State 14, Illinois 10 | Box score |
| Oct 28, 2000 | Ole Miss 43, UNLV 40 | Box score |
| Oct 28, 2000 | 20Mississippi State 61, Middle Tennessee 35 | Box score |
| Oct 28, 2000 | New Mexico 10, Utah 3 | Box score |
| Oct 28, 2000 | North Texas 13, Louisiana 0 | Box score |
| Oct 28, 2000 | Northern Illinois 73, Buffalo 10 | Box score |
| Oct 28, 2000 | 23Northwestern 41, Minnesota 35 | Box score |
| Oct 28, 2000 | 19Notre Dame 34, Air Force 31 | Box score |
| Oct 28, 2000 | 3Oklahoma 31, 1Nebraska 14upset | Box score |
| Oct 28, 2000 | 7Oregon 56, Arizona State 55 | Box score |
| Oct 28, 2000 | 18Oregon State 38, Washington State 9 | Box score |
| Oct 28, 2000 | Penn State 27, Indiana 24 | Box score |
| Oct 28, 2000 | 16Purdue 31, 12Ohio State 27upset | Box score |
| Oct 28, 2000 | San José State 57, Hawai’i 48 | Box score |
| Oct 28, 2000 | South Florida 21, UConn 13 | Box score |
| Oct 28, 2000 | SMU 21, Nevada 7 | Box score |
| Oct 28, 2000 | 14Southern Miss 6, Houston 3 | Box score |
| Oct 28, 2000 | Tennessee 17, 17South Carolina 14upset | Box score |
| Oct 28, 2000 | 22Texas 48, Baylor 14 | Box score |
| Oct 28, 2000 | Texas A&M 26, 10Kansas State 10upset | Box score |
| Oct 28, 2000 | 11TCU 37, Rice 0 | Box score |
| Oct 28, 2000 | Texas Tech 45, Kansas 39 | Box score |
| Oct 28, 2000 | Toledo 35, Navy 14 | Box score |
| Oct 28, 2000 | UCLA 27, 24Arizona 24upset | Box score |
| Oct 28, 2000 | Utah State 44, Arkansas State 31 | Box score |
| Oct 28, 2000 | Virginia 17, North Carolina 6 | Box score |
| Oct 28, 2000 | 2Virginia Tech 37, Pittsburgh 34 | Box score |
| Oct 28, 2000 | 9Washington 31, Stanford 28 | Box score |
| Oct 28, 2000 | Western Michigan 42, Kent State 0 | Box score |
| Oct 28, 2000 | Wisconsin 13, Iowa 7 | Box score |