| Nov 2, 2000 | Colorado State 45, BYU 21 | Box score |
| Nov 4, 2000 | Air Force 41, Army 27 | Box score |
| Nov 4, 2000 | Boise State 42, Arkansas State 14 | Box score |
| Nov 4, 2000 | Boston College 31, Temple 3 | Box score |
| Nov 4, 2000 | Buffalo 20, Kent State 17 | Box score |
| Nov 4, 2000 | UCF 20, Louisiana Tech 16 | Box score |
| Nov 4, 2000 | Cincinnati 33, UAB 21 | Box score |
| Nov 4, 2000 | Colorado 28, Missouri 18 | Box score |
| Nov 4, 2000 | Eastern Michigan 31, Central Michigan 15 | Box score |
| Nov 4, 2000 | 6Florida 43, Vanderbilt 20 | Box score |
| Nov 4, 2000 | 4Florida State 54, 10Clemson 7 | Box score |
| Nov 4, 2000 | Fresno State 45, Hawai’i 27 | Box score |
| Nov 4, 2000 | Idaho 16, North Texas 14 | Box score |
| Nov 4, 2000 | Illinois 42, Indiana 35 | Box score |
| Nov 4, 2000 | Iowa 26, Penn State 23upset | Box score |
| Nov 4, 2000 | 19Kansas State 56, Iowa State 10 | Box score |
| Nov 4, 2000 | Louisiana 21, UL Monroe 18upset | Box score |
| Nov 4, 2000 | LSU 30, Alabama 28 | Box score |
| Nov 4, 2000 | Louisville 49, 13Southern Miss 28upset | Box score |
| Nov 4, 2000 | Marshall 20, Bowling Green 13 | Box score |
| Nov 4, 2000 | Maryland 35, NC State 28 | Box score |
| Nov 4, 2000 | 3Miami 41, 2Virginia Tech 21upset | Box score |
| Nov 4, 2000 | Miami (OH) 27, Ohio 24 | Box score |
| Nov 4, 2000 | Middle Tennessee 66, UConn 10 | Box score |
| Nov 4, 2000 | Ole Miss 38, Arkansas 24 | Box score |
| Nov 4, 2000 | 18Mississippi State 35, Kentucky 17 | Box score |
| Nov 4, 2000 | 5Nebraska 56, Kansas 17 | Box score |
| Nov 4, 2000 | North Carolina 20, Pittsburgh 17upset | Box score |
| Nov 4, 2000 | 21Northwestern 54, 12Michigan 51upset | Box score |
| Nov 4, 2000 | 16Ohio State 27, Michigan State 13 | Box score |
| Nov 4, 2000 | 1Oklahoma 56, Baylor 7 | Box score |
| Nov 4, 2000 | 7Oregon 27, Washington State 24 | Box score |
| Nov 4, 2000 | 14Oregon State 38, California 32 | Box score |
| Nov 4, 2000 | Rice 43, SMU 14 | Box score |
| Nov 4, 2000 | San Diego State 17, New Mexico 16 | Box score |
| Nov 4, 2000 | San José State 27, 9TCU 24upset | Box score |
| Nov 4, 2000 | USC 44, Arizona State 38upset | Box score |
| Nov 4, 2000 | Syracuse 31, West Virginia 27 | Box score |
| Nov 4, 2000 | Tennessee 19, Memphis 17 | Box score |
| Nov 4, 2000 | 20Texas 29, Texas Tech 17 | Box score |
| Nov 4, 2000 | 24Texas A&M 21, Oklahoma State 16 | Box score |
| Nov 4, 2000 | UTEP 45, Nevada 22 | Box score |
| Nov 4, 2000 | Toledo 38, Northern Illinois 24 | Box score |
| Nov 4, 2000 | Tulane 41, Houston 23 | Box score |
| Nov 4, 2000 | UCLA 37, Stanford 35 | Box score |
| Nov 4, 2000 | Utah 38, UNLV 16 | Box score |
| Nov 4, 2000 | Utah State 44, New Mexico State 37 | Box score |
| Nov 4, 2000 | Wake Forest 28, Duke 26 | Box score |
| Nov 4, 2000 | 8Washington 35, Arizona 32 | Box score |
| Nov 4, 2000 | Western Michigan 42, Ball State 3 | Box score |
| Nov 4, 2000 | Wisconsin 41, Minnesota 20 | Box score |