| Nov 9, 2000 | 24Georgia Tech 35, Virginia 0 | Box score |
| Nov 11, 2000 | Air Force 44, Colorado State 40 | Box score |
| Nov 11, 2000 | Akron 49, Buffalo 14 | Box score |
| Nov 11, 2000 | Arkansas State 53, North Texas 28 | Box score |
| Nov 11, 2000 | 22Auburn 29, 14Georgia 26upset | Box score |
| Nov 11, 2000 | Boise State 66, Utah State 38 | Box score |
| Nov 11, 2000 | Central Michigan 21, Western Michigan 17upset | Box score |
| Nov 11, 2000 | Cincinnati 13, Memphis 10 | Box score |
| Nov 11, 2000 | East Carolina 62, Houston 20 | Box score |
| Nov 11, 2000 | Eastern Michigan 39, Northern Illinois 32upset | Box score |
| Nov 11, 2000 | 5Florida 41, 21South Carolina 21 | Box score |
| Nov 11, 2000 | 3Florida State 35, Wake Forest 6 | Box score |
| Nov 11, 2000 | Hawai’i 37, Nevada 17 | Box score |
| Nov 11, 2000 | Idaho 44, New Mexico State 41 | Box score |
| Nov 11, 2000 | Iowa 27, 12Northwestern 17upset | Box score |
| Nov 11, 2000 | Iowa State 35, Colorado 27 | Box score |
| Nov 11, 2000 | 16Kansas State 29, 4Nebraska 28upset | Box score |
| Nov 11, 2000 | LSU 20, Ole Miss 9 | Box score |
| Nov 11, 2000 | Louisiana Tech 42, UL Monroe 19 | Box score |
| Nov 11, 2000 | Louisville 38, Army 17 | Box score |
| Nov 11, 2000 | Marshall 51, Miami (OH) 31 | Box score |
| Nov 11, 2000 | 2Miami 35, Pittsburgh 7 | Box score |
| Nov 11, 2000 | 20Michigan 33, Penn State 11 | Box score |
| Nov 11, 2000 | Michigan State 30, 9Purdue 10upset | Box score |
| Nov 11, 2000 | Middle Tennessee 45, South Florida 9 | Box score |
| Nov 11, 2000 | 15Mississippi State 29, Alabama 7 | Box score |
| Nov 11, 2000 | Missouri 47, Baylor 22 | Box score |
| Nov 11, 2000 | UNLV 18, New Mexico 14 | Box score |
| Nov 11, 2000 | North Carolina 13, Maryland 10 | Box score |
| Nov 11, 2000 | NC State 35, Duke 31 | Box score |
| Nov 11, 2000 | 11Notre Dame 28, Boston College 16 | Box score |
| Nov 11, 2000 | Ohio 23, Bowling Green 21 | Box score |
| Nov 11, 2000 | 13Ohio State 24, Illinois 21 | Box score |
| Nov 11, 2000 | 1Oklahoma 35, 23Texas A&M 31 | Box score |
| Nov 11, 2000 | 6Oregon 25, California 17 | Box score |
| Nov 11, 2000 | 10Oregon State 33, Arizona 9 | Box score |
| Nov 11, 2000 | SMU 24, Tulsa 20 | Box score |
| Nov 11, 2000 | 25Southern Miss 33, UAB 30 | Box score |
| Nov 11, 2000 | Stanford 29, Arizona State 7 | Box score |
| Nov 11, 2000 | Syracuse 31, Temple 12 | Box score |
| Nov 11, 2000 | Tennessee 63, Arkansas 20 | Box score |
| Nov 11, 2000 | 19Texas 51, Kansas 16 | Box score |
| Nov 11, 2000 | 18TCU 24, Fresno State 7 | Box score |
| Nov 11, 2000 | Texas Tech 58, Oklahoma State 0 | Box score |
| Nov 11, 2000 | UTEP 38, Rice 21 | Box score |
| Nov 11, 2000 | Toledo 31, Ball State 3 | Box score |
| Nov 11, 2000 | Tulane 50, Navy 38 | Box score |
| Nov 11, 2000 | Utah 34, Wyoming 0 | Box score |
| Nov 11, 2000 | Vanderbilt 24, Kentucky 20 | Box score |
| Nov 11, 2000 | 8Virginia Tech 44, UCF 21 | Box score |
| Nov 11, 2000 | 7Washington 35, UCLA 28 | Box score |
| Nov 11, 2000 | Washington State 33, USC 27upset | Box score |
| Nov 11, 2000 | West Virginia 31, Rutgers 24 | Box score |
| Nov 11, 2000 | Wisconsin 43, Indiana 22 | Box score |