| Nov 16, 2000 | Colorado State 37, Wyoming 13 | Box score |
| Nov 18, 2000 | Air Force 45, San Diego State 24 | Box score |
| Nov 18, 2000 | Akron 34, Kent State 6 | Box score |
| Nov 18, 2000 | UAB 27, Army 7 | Box score |
| Nov 18, 2000 | Arkansas 17, 13Mississippi State 10upset | Box score |
| Nov 18, 2000 | 18Auburn 9, Alabama 0 | Box score |
| Nov 18, 2000 | Ball State 29, UConn 0 | Box score |
| Nov 18, 2000 | Boise State 66, Idaho 24 | Box score |
| Nov 18, 2000 | BYU 37, New Mexico 13 | Box score |
| Nov 18, 2000 | Cincinnati 27, 24Southern Miss 24upset | Box score |
| Nov 18, 2000 | 16Clemson 16, 25South Carolina 14 | Box score |
| Nov 18, 2000 | 3Florida State 30, 4Florida 7 | Box score |
| Nov 18, 2000 | Fresno State 14, SMU 7 | Box score |
| Nov 18, 2000 | 22Georgia 32, Ole Miss 14 | Box score |
| Nov 18, 2000 | 20Georgia Tech 35, Maryland 22 | Box score |
| Nov 18, 2000 | Hawai’i 27, Louisiana Tech 10 | Box score |
| Nov 18, 2000 | Iowa State 38, Kansas 17 | Box score |
| Nov 18, 2000 | 9Kansas State 28, Missouri 24 | Box score |
| Nov 18, 2000 | Louisville 32, Houston 13 | Box score |
| Nov 18, 2000 | 2Miami 26, Syracuse 0 | Box score |
| Nov 18, 2000 | Miami (OH) 17, Buffalo 16 | Box score |
| Nov 18, 2000 | 19Michigan 38, 12Ohio State 26upset | Box score |
| Nov 18, 2000 | Middle Tennessee 41, Louisiana 38 | Box score |
| Nov 18, 2000 | Minnesota 27, Iowa 24 | Box score |
| Nov 18, 2000 | Nevada 34, Rice 28 | Box score |
| Nov 18, 2000 | North Carolina 59, Duke 21 | Box score |
| Nov 18, 2000 | North Texas 30, New Mexico State 23 | Box score |
| Nov 18, 2000 | Northern Illinois 40, Central Michigan 6 | Box score |
| Nov 18, 2000 | 23Northwestern 61, Illinois 23 | Box score |
| Nov 18, 2000 | 11Notre Dame 45, Rutgers 17 | Box score |
| Nov 18, 2000 | Ohio 38, Marshall 28 | Box score |
| Nov 18, 2000 | 1Oklahoma 27, Texas Tech 13 | Box score |
| Nov 18, 2000 | Oklahoma State 50, Baylor 22 | Box score |
| Nov 18, 2000 | 8Oregon State 23, 5Oregon 13upset | Box score |
| Nov 18, 2000 | Penn State 42, Michigan State 23 | Box score |
| Nov 18, 2000 | Pittsburgh 7, Temple 0 | Box score |
| Nov 18, 2000 | 17Purdue 41, Indiana 13 | Box score |
| Nov 18, 2000 | USC 38, UCLA 35 | Box score |
| Nov 18, 2000 | Stanford 36, California 30 | Box score |
| Nov 18, 2000 | Tennessee 59, Kentucky 20 | Box score |
| Nov 18, 2000 | 15TCU 47, UTEP 14 | Box score |
| Nov 18, 2000 | Tulane 37, Memphis 14 | Box score |
| Nov 18, 2000 | Tulsa 28, San José State 17upset | Box score |
| Nov 18, 2000 | Virginia 24, NC State 17 | Box score |
| Nov 18, 2000 | Wake Forest 49, Navy 26 | Box score |
| Nov 18, 2000 | 6Washington 51, Washington State 3 | Box score |
| Nov 18, 2000 | West Virginia 42, East Carolina 24 | Box score |
| Nov 18, 2000 | Western Michigan 28, Eastern Michigan 0 | Box score |