| Oct 12, 2000 | 3Virginia Tech 48, West Virginia 20 | Box score |
| Oct 14, 2000 | Air Force 51, Wyoming 34 | Box score |
| Oct 14, 2000 | Alabama 45, Ole Miss 7 | Box score |
| Oct 14, 2000 | UAB 13, Memphis 9 | Box score |
| Oct 14, 2000 | 22Arizona 53, Washington State 47 | Box score |
| Oct 14, 2000 | Ball State 33, Eastern Michigan 14 | Box score |
| Oct 14, 2000 | Boston College 20, Syracuse 13 | Box score |
| Oct 14, 2000 | California 46, 13UCLA 38upset | Box score |
| Oct 14, 2000 | 5Clemson 35, Maryland 14 | Box score |
| Oct 14, 2000 | Colorado State 20, UNLV 19 | Box score |
| Oct 14, 2000 | East Carolina 42, Army 21 | Box score |
| Oct 14, 2000 | 10Florida 38, 19Auburn 7 | Box score |
| Oct 14, 2000 | 7Florida State 63, Duke 14 | Box score |
| Oct 14, 2000 | Fresno State 58, Nevada 21 | Box score |
| Oct 14, 2000 | 14Georgia 29, Vanderbilt 19 | Box score |
| Oct 14, 2000 | Georgia Tech 52, Wake Forest 20 | Box score |
| Oct 14, 2000 | Hawai’i 30, SMU 15 | Box score |
| Oct 14, 2000 | Idaho 42, Arkansas State 25 | Box score |
| Oct 14, 2000 | Illinois 31, Iowa 0 | Box score |
| Oct 14, 2000 | Iowa State 33, Oklahoma State 26 | Box score |
| Oct 14, 2000 | Kansas 38, Missouri 17 | Box score |
| Oct 14, 2000 | LSU 34, Kentucky 0 | Box score |
| Oct 14, 2000 | Louisiana Tech 48, Louisiana 14 | Box score |
| Oct 14, 2000 | Louisville 38, Cincinnati 24 | Box score |
| Oct 14, 2000 | Miami (OH) 24, Bowling Green 10 | Box score |
| Oct 14, 2000 | 18Michigan 58, Indiana 0 | Box score |
| Oct 14, 2000 | Middle Tennessee 28, UL Monroe 0 | Box score |
| Oct 14, 2000 | Minnesota 29, 6Ohio State 17upset | Box score |
| Oct 14, 2000 | 1Nebraska 56, Texas Tech 3 | Box score |
| Oct 14, 2000 | New Mexico State 42, Tulsa 28 | Box score |
| Oct 14, 2000 | NC State 38, North Carolina 20 | Box score |
| Oct 14, 2000 | Northern Illinois 52, Akron 35upset | Box score |
| Oct 14, 2000 | 20Notre Dame 45, Navy 14 | Box score |
| Oct 14, 2000 | Ohio 44, Kent State 7 | Box score |
| Oct 14, 2000 | 8Oklahoma 41, 2Kansas State 31upset | Box score |
| Oct 14, 2000 | 9Oregon 28, USC 17 | Box score |
| Oct 14, 2000 | 23Oregon State 38, Stanford 6 | Box score |
| Oct 14, 2000 | 21Purdue 41, 17Northwestern 28upset | Box score |
| Oct 14, 2000 | 24South Carolina 27, Arkansas 7 | Box score |
| Oct 14, 2000 | 16Southern Miss 56, Tulane 24 | Box score |
| Oct 14, 2000 | Temple 48, Rutgers 14 | Box score |
| Oct 14, 2000 | 25Texas 28, Colorado 14 | Box score |
| Oct 14, 2000 | Texas A&M 24, Baylor 0 | Box score |
| Oct 14, 2000 | UTEP 47, San José State 30 | Box score |
| Oct 14, 2000 | Toledo 42, Marshall 0 | Box score |
| Oct 14, 2000 | Utah 21, San Diego State 7 | Box score |
| Oct 14, 2000 | Utah State 17, North Texas 12 | Box score |
| Oct 14, 2000 | 11Washington 21, Arizona State 15 | Box score |
| Oct 14, 2000 | Wisconsin 17, Michigan State 10 | Box score |