| Oct 5, 2000 | Fresno State 27, Rice 24 | Box score |
| Oct 5, 2000 | Western Michigan 30, Marshall 10upset | Box score |
| Oct 6, 2000 | BYU 38, Utah State 14 | Box score |
| Oct 7, 2000 | Air Force 27, Navy 13 | Box score |
| Oct 7, 2000 | Akron 27, Bowling Green 21 | Box score |
| Oct 7, 2000 | Arizona 31, 18USC 15upset | Box score |
| Oct 7, 2000 | Arizona State 30, California 10 | Box score |
| Oct 7, 2000 | Arkansas 52, UL Monroe 6 | Box score |
| Oct 7, 2000 | Ball State 15, Miami (OH) 10upset | Box score |
| Oct 7, 2000 | Boston College 55, UConn 3 | Box score |
| Oct 7, 2000 | Cincinnati 48, Houston 31 | Box score |
| Oct 7, 2000 | 5Clemson 34, NC State 27 | Box score |
| Oct 7, 2000 | Colorado 26, Texas A&M 19upset | Box score |
| Oct 7, 2000 | Colorado State 17, New Mexico 14 | Box score |
| Oct 7, 2000 | 12Florida 41, LSU 9 | Box score |
| Oct 7, 2000 | 19Georgia 21, 21Tennessee 10 | Box score |
| Oct 7, 2000 | Iowa 21, Michigan State 16upset | Box score |
| Oct 7, 2000 | 4Kansas State 52, Kansas 13 | Box score |
| Oct 7, 2000 | Kent State 24, Central Michigan 21upset | Box score |
| Oct 7, 2000 | Louisville 38, UAB 17 | Box score |
| Oct 7, 2000 | Memphis 17, East Carolina 10 | Box score |
| Oct 7, 2000 | 7Miami 27, 1Florida State 24upset | Box score |
| Oct 7, 2000 | Middle Tennessee 49, Louisiana Tech 21 | Box score |
| Oct 7, 2000 | Minnesota 25, Penn State 16 | Box score |
| Oct 7, 2000 | Ole Miss 35, Arkansas State 10 | Box score |
| Oct 7, 2000 | 20Mississippi State 17, 15Auburn 10upset | Box score |
| Oct 7, 2000 | Missouri 24, Oklahoma State 10 | Box score |
| Oct 7, 2000 | 2Nebraska 49, Iowa State 27 | Box score |
| Oct 7, 2000 | UNLV 38, Nevada 7 | Box score |
| Oct 7, 2000 | New Mexico State 42, Army 23 | Box score |
| Oct 7, 2000 | Northern Illinois 40, UCF 20 | Box score |
| Oct 7, 2000 | 22Northwestern 52, Indiana 33 | Box score |
| Oct 7, 2000 | 25Notre Dame 20, Stanford 14 | Box score |
| Oct 7, 2000 | Ohio 42, Buffalo 20 | Box score |
| Oct 7, 2000 | 8Ohio State 23, 24Wisconsin 7 | Box score |
| Oct 7, 2000 | 10Oklahoma 63, 11Texas 14 | Box score |
| Oct 7, 2000 | Purdue 32, 6Michigan 31upset | Box score |
| Oct 7, 2000 | San Diego State 34, Wyoming 0 | Box score |
| Oct 7, 2000 | San José State 35, SMU 10 | Box score |
| Oct 7, 2000 | South Carolina 20, Kentucky 17 | Box score |
| Oct 7, 2000 | 17Southern Miss 41, South Florida 7 | Box score |
| Oct 7, 2000 | Syracuse 24, Pittsburgh 17 | Box score |
| Oct 7, 2000 | 14TCU 41, Hawai’i 21 | Box score |
| Oct 7, 2000 | Texas Tech 28, Baylor 0 | Box score |
| Oct 7, 2000 | UTEP 40, Tulsa 7 | Box score |
| Oct 7, 2000 | Toledo 42, Eastern Michigan 14 | Box score |
| Oct 7, 2000 | Tulane 38, Louisiana 37 | Box score |
| Oct 7, 2000 | Vanderbilt 17, Wake Forest 10 | Box score |
| Oct 7, 2000 | Virginia 31, Maryland 23 | Box score |
| Oct 7, 2000 | 3Virginia Tech 35, Temple 13 | Box score |
| Oct 7, 2000 | 13Washington 33, 23Oregon State 30 | Box score |
| Oct 7, 2000 | Washington State 42, Boise State 35 | Box score |
| Oct 7, 2000 | West Virginia 28, Idaho 16 | Box score |